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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | Multilayer 3D Chirality and Its Synthetic Assembly显示文摘3D chirality of sandwich type of organic molecules has been discovered.Te key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane.Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC.Te absolute confguration was unambiguously assigned by X-ray difraction analysis.Tis is the frst multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical,medicinal,and material sciences in future. | Guanzhao Wu Yangxue Liu Zhen Yang Nandakumar Katakam Hossein Rouh Sultan Ahmed Daniel Unruh Kazimierz Surowiec Guigen Li | 2019 | Research2019，，1： | 3 |
| 3 | Influence of wet activation of used inorganic binder on cyclically refreshed water glass moulding sands hardened by microwaves显示文摘The paper presents the research results of using an innovative method to reclaim the waste moulding sands containing water glass. Two of the examined processes are connected with 'dry' or 'wet' activation of inorganic binder in waste moulding sand mixtures physically hardened by microwave radiation. The sand mixtures consisting of high-silica sand and water-glass with average molar module 2.5, were subjected to the following cyclical process: mixing the components, compacting, microwave heating, cooling-down, thermally loading the mould to 800 °C, cooling-down to ambient temperature, and knocking-out. After being knocked-out, the waste moulding sands were subjected to either dry or wet activation of the binder. To activate thermally treated inorganic binder, each of the examined processes employed the surface phenomenon usually associated to mechanical reclamation. The study also covered possible use of some elements of wet reclamation to rehydrate waste binder. To evaluate the effectiveness of the two proposed methods of waste binder activation, selected strength and technological parameters were measured. After each subsequent processing cycle, the permeability, tensile strength and bending strength were determined. In addition, the surface of activated sand grains was examined with a scanning electron microscope. Analysis of the results indicates that it is possible to re-activate the used binder such as sodium silicate, and to stabilize the strength parameters in both activation processes. Permeability of the refreshed moulding sands strongly depends on the surface condition of high-silica grains. The wet activation process by wetting and buffering knocked-out moulding sands in closed humid environment makes it possible to reduce the content of refreshing additive in water-glass. The moulding sands cyclically prepared in both processes do not require the addition of fresh high-silica sand. The relatively high quality achieved in the refreshed moulding sands allows them to be reused for manufacture of next moulds. Thus, the two proposed methods for cyclically processing used moulding sands containing sodium silicate, subject to microwave hardening, are suitable for economic and ecological circulation moulding mixtures. | Mateusz Stachowicz Kazimierz Granat | 2016 | China Foundry2016，13，6： | 3 |
| 4 | Pretreatment procedures for characterization of arsenic and selenium species in complex samples utilizing coupled techniques with mass spectrometric detection显示文摘 | Katarzyna Wrobel Kazimierz Wrobel Joseph A. Caruso | 2005 | Analytical and Bioanalytical Chemistry2005，，2： | 1 |
| 5 | Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase and ion-pair high-performance liquid chromatography显示文摘 | TOMASZ M KAZIMIERZ G ANNA W | 2002 | J Chromatography A2002，949，12： | 1 |
| 6 | Tissue harmonic imaging of thyroid nodules: initial experience显示文摘 | Kazimierz T Szopinski MD Wysocki M | 2003 | J Ultrasound Med2003，22，1： | 1 |
| 7 | On-line strcture characterization of pyrrolizidine alkaloids in Onosma stel- lulatum and Emilia coccinea by liquid chromatography-ion-trap mass spectrometry显示文摘 | TOMASZ M KARINE N KAZIMIERZ G | 2004 | J Chromatography A2004，1056，12： | 1 |
| 8 | Nickel carcinogenesis显示文摘 | Kazimierz S Kasp rzaka F William-Sunderman J | 2003 | Mutation Research2003，533，： | 1 |
| 9 | Boresight errors induced by missile radomes显示文摘 | Kazimierz Siwiak Thomas B Dowling | 1979 | IEEE Trans on AP1979，27，6： | 1 |
| 10 | Economic Adjustment and Politi- cal Forces: Poland since 1970显示文摘 | Kazimierz Poznanski | 1986 | International Organi- zation1986，40，2： | 1 |
| 11 | Effects of massaging time and dram speed on texture and structure of two beef muscle显示文摘 | Kazimierz Lachowicz | | 0，，02： | 1 |
| 12 | Remarks on strongly convex functions显示文摘 | Nelson Merentes Kazimierz Nikodem | 2010 | Aequationes Mathematicae2010，80，12： | 1 |
| 13 | Electron beam activated brazing of cubic boron nitride to tungsten carbide cutting tools显示文摘 | Jan Felba Kazimierz P Friedel Peter Krull | 2001 | Vacuum2001，62，5： | 1 |
| 14 | Limit strains in the processes of stretch forming sheet metal 显示文摘 | Zdzislaw Marciniak Kazimierz Kuczynski | 1967 | Interna- tional Journal of Mechanical science1967，，9： | 1 |
| 15 | A deposition efficiency of dust particles on a single, falling and charged water droplet显示文摘 | Kazimierz Adamiak Anatol Jaworek Ardrzej Krup | 2001 | IEEE Trans IA2001，37，： | 1 |
| 16 | Electron beam activated brazing of cubic boron nitride to tungsten carbide cutting tools显示文摘 | JAN Felba KAZIMIERZ P Friedel PETER Krull | 2001 | Vacuum2001，，62： | 1 |
| 17 | Adsorptive Bubble Separation of Zinc and Cadmium Cations in Presence of Ferric and Aluminum Hydroxides显示文摘 | Kazimierz Jurkiewicz | 2005 | Journal of Colloid and Interface Science2005，286，： | 1 |
| 18 | Cellular subsets of the milky spots in the human greater omentum显示文摘 | Masataka Shimotsuma Toshio Takahashi Mitsuhiro Kawata Kazimierz Dux | 1991 | Cell and Tissue Research1991，，3： | 1 |
| 19 | The influence of porous silicon on junction formation in silicon solar cells显示文摘 | Kazimierz Drabczyk Piotr Panek Marek | 2003 | Solar Energy Material & Solar Cells2003，76，： | 1 |
| 20 | The cold chain, one link in Canada's food safety initiatives显示文摘 | Alex Kassianenko Kazimierz Wszol | 2006 | Food Control2006，，18： | 1 |
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