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| 1 | Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks显示文摘AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans. | Martins C Kedda MA Kew MC | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 2 | The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population 显示文摘 | Kedda MA Lose F Duffy D | 2005 | Thorax2005，60，3： | 1 |
| 3 | PSA/KLK3 AREI promoter poly-morphism alters androgen receptor binding and is associated wi-th prostate cancer susceptibility显示文摘 | Lai J Kedda MA Hinze K | 2007 | Carcinogenesis2007，28，5： | 1 |
| 4 | Nonspecific messenger RNA of a-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans显示文摘 | Kedda MA Kew MC Skelton M | 1998 | Gastroenterol Hepatol1998，13，6： | 1 |
| 5 | The tyrosinase-positivc oculocutaneous albinism gene shows locus homogeneity on chromosome 15q11-q13 and evidence of multiple mutations in southern African negroids显示文摘 | Kedda MA Stevens G Manga P | 1994 | Am J Hum Genet1994，54，6： | 1 |
| 6 | Human papillomavirus DNA detected in peripheral blood samples from healthy Aus- tralian male blood donors 显示文摘 | Chen AC Keleher A Kedda MA | 2009 | J Med Virol2009，81，10： | 1 |
| 7 | Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma 显示文摘 | Shi J Misso NL Kedda MA | 2008 | Clin Exp Allergy2008，38，6： | 1 |
| 8 | The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks显示文摘 | MC Kew MC Yu MA Kedda A Coppin A Sarkin J Hodkinson | 1997 | Gastroenterology1997，，1： | 1 |
| 9 | Non-specificity of messenger RNA of alpha-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans显示文摘 | Kedda MA Kew MC Skelton M | 1998 | J GasLroenterol Hepatol1998，13，9： | 1 |
| 10 | ADAM33 haplotypes are associated with asthma in a large Australian population 显示文摘 | Kedda MA Dully DL Bradley B | 2006 | Eur J Hum Genet2006，14，9： | 1 |
| 11 | Non-specificity of messenger RNA of alpha-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans 显示文摘 | Kedda MA Kew MC Skelton M | 1998 | J Gastroenterol Hepatol1998，13，9： | 1 |
| 12 | Characterization of two poly morphisms in the leukotriene C4 synthase gene in an Austral Jan population of subjects with mild, moderate,and severe asthma显示文摘 | Kedda MA Shi J Duffy D | 2004 | J Allergy Clin Immunol2004，113，5： | 1 |
| 13 | Characterization of two polymorphisms in the leukotriene C4- synthase gene in an Australian population of subjects with mild, moderate, and severe asthma 显示文摘 | Kedda MA Shi J Duffy D | 2004 | J Allergy Clin Immunol2004，113，5： | 1 |
| 14 | Non-specificity of messenger RNA of alpha-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans 显示文摘 | Kedda MA Kew MC Skehon M | 1998 | J Gastroenterol Hepatol1998，13，9： | 1 |
| 15 | Non-specificity of messenger RNA of alpha-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans 显示文摘 | Kedda MA Kew MC Skelton M | 1998 | J Gastroenterol Hepatol1998，13，9： | 1 |
| 16 | ADAM33 haplotypes areassociated with asthma in a large Australian population显示文摘 | Kedda MA Duffy DL Bradley B | 2006 | Eur JHum Genet2006，14，： | 1 |
| 17 | Non-specificity of messenger RNA of alpha-fetoprotein in peripheral blood in de tecting early spread of hepatocellular carcinoma in black Africans显示文摘 | Kedda MA Kew MC Skehon M | 1998 | J Gastroenterol-Hepatol1998，13，9： | 1 |
| 18 | Cyclooxygenase - 2 gene polymorphisms in an Australian population: as- sociation of the - 1195G > A promoter polymorphism with mild asthma 显示文摘 | J Shi NL Misso MA Kedda | 2008 | Clin and Exp Allergy2008，38，： | 1 |
| 19 | ADAM33 haplotypes are associated with asthma in a large Australian population显示文摘 | Kedda MA Duffy DL Bradley B | 2006 | Eur J Hum Genet2006，14，： | 1 |
| 20 | Cyelooxygenase-2 gene polymorphisms in an Australian population: association of the - 1195G : A promoter polymorphism with mild asthma显示文摘 | Shi J Misso NL Kedda MA | 2008 | Clin Exp Allergy2008，38，6： | 1 |
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