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| 1 | BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy显示文摘Dysregulation of circadian rhythms associates with cardiovascular disorders.It is known that deletion of the core circadian gene Bma/1 in mice causes dilated car-diomyopathy.However,the biological rhythm regulation system in mouse is very different from that of humans.Whether BMAL1 plays a role in regulating human heart function remains unclear.Here we generated a BMAL1 knockout human embryonic stem cell(hESC)model and further derived human BMAL1 deficient cardiomy-ocytes.We show that BMAL1 deficient hESC-derived cardiomyocytes exhibited typical phenotypes of dilated cardiomyopathy including attenuated contractility,cal-cium dysregulation,and disorganized myofilaments.In addition,mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes,which resulted in significantly attenuated mitochondrial oxidative phosphorylation and compromised cardiomy-ocyte function.We also found that BMAL1 binds to the E-box element in the promoter region of BNIP3 gene and specifically controls BNIP3 protein expression.BMAL1 knockout directly reduced BNIP3 protein level,causing compromised mitophagy and mitochondria dysfunction and thereby leading to compromised cardiomyocyte function.Our data indicated that the core circadian gene S/VMLf is critical for normal mitochondria activities and cardiac function.Circadian rhythm disruption may directly link to compromised heart function and dilated cardiomyopathy in humans. | Ermin Li Xiuya Li Jie Huang Chen Xu Qianqian Liang Kehan Ren Aobing Bai Chao Lu Ruizhe Qian Ning Sun | 2020 | Protein & Cell2020，11，9： | 17 |
| 2 | Highly Sensitive Protein Sensor Based on Thermally-Reduced Graphene Oxide Field-Effect Transistor显示文摘我们报导一只高度敏感的地效果晶体管(联邦货物税) 的制造用减少 thermally 的 graphene 氧化物(TRGO ) 的生物传感器有抗体结合的金 nanoparticle (NP ) 的表 functionalized。探查抗体通过 Au NP 在 TRGO 表的表面上被标记,蛋白质绑定(免疫球蛋白 G/IgG 和反免疫球蛋白 G/anti-IgG ) 的电的察觉被联邦货物税和直接电流(dc ) 完成大小。蛋白质绑定事件在 TRGO 表的电阻导致了重要变化,它被叫作传感器反应。在 TRGO 表上的传感器和抗体 areal 密度中的 TRGO 基础电阻上的传感器反应的依赖系统地被学习,从哪个有传感器参数的传感器反应的关联被发现:传感器反应与更大的 TRGO 基础电阻和更高的抗体 areal 密度是更重要的。新奇生物传感器的察觉限制在 0.2 ng/mL 水平附近,它在报导的碳的最好之中基于 nanomaterial 的蛋白质传感器和罐头被调节传感器结构进一步优化。 | Shun Mao Kehan Yu Ganhua Lu Junhong Chen | 2011 | Nano Research2011，4，10： | 6 |
| 3 | Fabrication of large area hexagonal boron nitride thin films for bendable capacitors显示文摘高度可靠、可弯曲的电介质为未来应用在灵活或可弯曲的电子设备被需要。六角形的硼氮化物(h-BN ) 能由于它的宽乐队差距被用作可弯曲的电介质。这里,我们由一个低压力化学药品蒸汽免职方法与可控制的厚度制作高质量的 h-BN 电影。我们作为电介质用 h-BN 电影表明一个平行板的电容器。h-BN 电容器与 9.0 MV/cm 的高故障地力量是可靠的。越过 h-BN 电影的通道电流对电介质的厚度相反地指数,它让电容显著地落下。h-BN 电容器显示出 6.8 F/cm2 的一个最好的特定的电容,它比计算的值高一个数量级。 | Ning Guo Jinquan Wei Yi Jia Huanhuan Sun Yuhang Wang Kehan Zhao Xiaolan Shi Liuwan Zhang Xinming Li Anyuan Cao Hongwei Zhu Kunlin Wang Dehai Wu | 2013 | Nano Research2013，6，8： | 3 |
| 4 | Enabling a stable and dendrite-suppressed Zn anode via facile surface roughness engineering显示文摘The safety and cycle lifespan of zinc metal-based aqueous batteries are greatly restricted by zinc anode.The poor cycling performance of zinc metal anode is often considered to be impacted by the dendrite growth,surface passivation,zinc metal corrosion and hydrogen evolution reaction,while surface roughness is a matter that has often been ignored in past studies.Herein,a roughness gradient is constructed on the zinc anode surface by a simple grinding and pasting method.It has been found the modified zinc anodes with lower surface roughness exhibit the smaller zinc deposition overpotential and longer cycle life.Further,in situ optical microscopy photographs indicate that the zinc anode with an optimized roughness enables more uniform distribution of zinc precipitation and corrosion sites,which will facilitate a stable cycling performance of aqueous zinc ion batteries.The Zn anode dendrite-suppressing mechanism via surface roughness engineering was revealed through finite element computational simulation.These results emphasize the effectiveness of roughness engineering for tuning the surface physics of Zn anode and provide a facile strategy to develop better and safer aqueous zinc ion batteries. | Jinghao Li Kehan Le Wei Wei | 2022 | Journal of Materials Science & Technology2022，，7： | 2 |
| 5 | One-step fabrication and capacitive behavior of electrochemical double layer capacitor electrodes using vertically-oriented graphene directly grown on metal显示文摘 | Zheng Bo Zhenhai Wen Haejune Kim Ganhua Lu Kehan Yu Junhong Chen | 2012 | Carbon2012，，12： | 1 |
| 6 | Contour error reduction for free-form contour following tasks of biaxial motion control systems显示文摘 | CHENG Mingyang SU Kehan WANG Shufeng | 2009 | Robotics and Computer-Integrated Manufaeturing2009，25，2： | 1 |
| 7 | Contouring accuracy improvement using cross-coupled control and position error compensator显示文摘 | SU Kehan CHENG Mingyang | 2008 | International Journal of Machine Tools and Manufacture2008，48，12： | 1 |
| 8 | A fast algorithm for kinematic chain isomorphism identification based on dividing and matching vertices显示文摘 | ZENG Kehan FAN Xiaogui DONG Mingchui | 2014 | Mechanism and Machine Theory2014，72，12： | 1 |
| 9 | Contouring accuracy improvement using cross-coupled control and position error compensator显示文摘 | SU Kehan CHENG Mingyang | 2008 | International Journal of MachineTools and Manufacture2008，48，： | 1 |
| 10 | Enhanced Efficiency of Dye-sensitized Solar Cells Using rGO@TiO2 Nanotube Hybrids显示文摘 | LIU Rui QIAO Yingjie SONG Yingjin SONG Kehan LIU Chuan | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 11 | Mutations of p53 gene isthe prognostic factor in the progression of oral squamous cell carci-noma (OSCC) in Pakistan 显示文摘 | Saleem S Hameed A Kehan MA | 2011 | Oral 0ncol2011，9，47： | 1 |
| 12 | Correlation of shear wave velocity with liquefaction resistance based on laboratory tests显示文摘 | Chen Y M Kehan A Chen R P | 2005 | Soil Dynamic and Earthquake Engineering2005，25，： | 1 |
| 13 | PbS quantum dots as a saturable absorber for ultrafast laser显示文摘Low-dimensional nanomaterials, owing to their unique and versatile properties, are very attractive for enormous electronic and optoelectronic applications. PbS quantum dots(QDs), characterized by a large Bohr radius and size-tunable bandgap, are especially interesting for photonic applications in the near-infrared region. Here, oleic acid capped colloidal PbS QDs as a saturable absorber are investigated for ultrashort-pulse generation. The PbS QDs exhibit outstanding nonlinear saturable absorption properties at 1550 nm: a modulation depth up to 44.5%and a thermal damage threshold larger than 30 mJ∕cm^2. By incorporating PbS QDs into a fiber laser, a transform-limited soliton pulse as short as 559 fs with a bandwidth of 4.78 nm is realized at 1563 nm. Numerous applications may benefit from the nonlinear saturable absorption properties of PbS QDs, such as near-infrared pulsed lasers and | LING YUN YANG QIU CONGHAO YANG JIE XING KEHAN YU XIANGXING XU WEI WEI | 2018 | Photonics Research2018，，11： | 1 |
| 14 | Choosing software metrics for defect prediction:an investigation on feature selection techniques显示文摘 | Gao Kehan Khoshgoftaar T Wang Huanjing | 2011 | Software-Practice and Experience2011，41，5： | 1 |
| 15 | A comprehensive empirical study ofcount models for software fault prediction显示文摘 | Kehan G Khoshgoftaar T M | 2007 | IEEE Transactions onReliability2007，56，2： | 1 |
| 16 | Contour Er-ror Reduction for Free-form Contour Following Tasks of Bi-axial Motion Control Systems 显示文摘 | CHENG Mingyang SU Kehan WANG Shufeng | 2009 | Robotics and Computer-Integrated Manufacturing2009，25，2： | 1 |
| 17 | Contouring accuracy improvement using cross-coupled control and position error compensator显示文摘 | SU Kehan CHENG Yangming | | 0，，12： | 1 |
| 18 | Electrolyte Design for Low‑Temperature Li‑Metal Batteries:Challenges and Prospects显示文摘Electrolyte design holds the greatest opportunity for the development of batteries that are capable of sub-zero temperature operation.To get the most energy storage out of the battery at low temperatures,improvements in electrolyte chemistry need to be coupled with optimized electrode materials and tailored electrolyte/electrode interphases.Herein,this review critically outlines electrolytes’limiting factors,including reduced ionic conductivity,large de-solvation energy,sluggish charge transfer,and slow Li-ion transportation across the electrolyte/electrode interphases,which affect the low-temperature performance of Li-metal batteries.Detailed theoretical derivations that explain the explicit influence of temperature on battery performance are presented to deepen understanding.Emerging improvement strategies from the aspects of electrolyte design and electrolyte/electrode interphase engineering are summarized and rigorously compared.Perspectives on future research are proposed to guide the ongoing exploration for better low-temperature Li-metal batteries. | Siyu Sun Kehan Wang Zhanglian Hong Mingjia Zhi Kai Zhang Jijian Xu | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 19 | Concise synthesis of NaTi_2(PO_4)_3 nanocrystals with size and morphology control显示文摘NaTi_2 (PO_4)_3 (NTP) nanocrystals with high room-temperature ionic conductivity of 1.1×10~3 S/cm were prepared by a concise solvothermal method at 140 ℃ for 3 h, and the aspect ratios of all the NTP nanocrystals are the closest to 0.7. It implies a moderate size-distribution of NTP nanocrystals obtained at 140 ℃ for 3 h is helpful for increasing packing density, and the packing density is the larger, so its conductivity is the higher. The controllability over size and morphology of the NTP nanocrystals via solvothermal temperature and time were investigated. The results suggest that our method is of great potential in synthesizing NTP nanocrystals with high room-temperature ionic conductivity at low cost. | Hanqing Dai Wenqian Xu Kehan Yu Wei Wei | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 20 | Centrifuge modelling of tunnelling below existing twin tunnels with different types of support显示文摘Tunnel excavation below existing tunnels produces ultimate and serviceability problems to the existing tunnels.The behaviours of induced stresses on the existing tunnels haven’t yet been fully recognized.In this study,a centrifuge model test was adopted to investigate the effects of new tunnelling on two existing overlying tunnels.One existing tunnel model simulated a prototype composite lining tunnel and the other simulated a prototype segmental lining tunnel.The volume loss produced by new tunnel excavation was modelled by an in-flight actuator system.The surface settlements,the existing tunnels settlements,the soil pressures on existing tunnels,the bending movements of existing tunnels,and the joint behaviours of existing tunnels were monitored.The volume of surface settlement trough was much smaller than the soil volume moving into the tunnel,due to the heave of the tunnel bottom and the dilation of sand during shearing.The maximum settlement of the segmental lining model was larger than that of the composite lining model as the equivalent bending stiffness of the composite lining model was larger than that of the former.Due to new tunnel excavation,the soil pressures on different positions of the existing tunnel behaved differently,and the bending movements of the existing tunnels decreased.Moreover,the joint deformation of existing tunnel caused by new tunnel excavation could be classified into three types:(1)translation,(2)rotation,and(3)combination of both. | Qian Fang Xiang Liu Kehan Zeng Xuedong Zhang Mozhen Zhou Jianming Du | 2022 | Underground Space2022，7，6： | 0 |
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