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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Systematic review:glucose control and cardiovascular disease in type 2 diabetes显示文摘 | Kelly TN Bazzano LA Fonseca VA | | Annals of Internal Medicine0，，： | 2 |
| 3 | Caspase 3 activity is required for skeletal muscle differentiation显示文摘 | Fernando P Kelly JF Megeney LA | 2002 | PNAS2002，99，11： | 1 |
| 4 | Causes and correlates of recurrent falls in ambulatory frail elderly 显示文摘 | Liosits LA Jonsson PW Kelly MM | 1991 | Gerontol Med Sci1991，46，1： | 1 |
| 5 | Lower Mortality in Magnet Hospitals显示文摘 | Mchugh MD Kelly LA Smith HL | 2013 | Medical Care2013，51，5： | 1 |
| 6 | Dietary fi- ber and associations with adiposity and fasting insulin among college students with plausible dietary reports 显示文摘 | Byrd-Williams CE Strother ML Kelly LA | 2009 | Nutrition2009，25，： | 1 |
| 7 | Up regulation of prostaglandin Ep4 receptor messenger RNA in fetal rabbit skin wound显示文摘 | LI HS HEBDA PA KELLY LA | 2000 | Arch Otolaryngol Head Surg2000，126，11： | 1 |
| 8 | Influence of Gender, Weight and Hispanic Ethnicity on Physical Activity in Tod- dlers显示文摘 | Marten AS Andrews A Kelly LA | 2015 | Medicine & Science in Sports & Exercise2015，47，5： | 1 |
| 9 | Galactose-α-1 ,3-galactose-specific Ig E is associated with anaphylaxis but not asthma显示文摘 | Commins SP Kelly LA Rnmark E | 2012 | Am J Respir Crit Care Med2012，185，7： | 1 |
| 10 | Galactose- oL-1, 3-galactose-specific IgE is associated with anaphy]axis but not asthma 显示文摘 | Commins SP Kelly LA Rfinmark E | 2012 | Am J RespirCrit Care Med2012，185，： | 1 |
| 11 | Diagnostic useful-ness of the ABCD2 score to distinguish transient ischemicattack and minor ischemic stroke from noncerebrovascularevents: The North Dublin TIA Study 显示文摘 | Sheehan OC Merwick A Kelly LA | 2009 | Stroke2009，40，11： | 1 |
| 12 | Rapid, quantitative reverse transcriptise polymerise chain reaction: application to intraoperative molecular detection of occult metastases in esophageal cancer 显示文摘 | Raja S Luketich JD Kelly LA | 2002 | J Thorac Cardiovasc Surg2002，123，3： | 1 |
| 13 | Population-based study of ABCD2 score,carotid stenosis,and atrial fibrillation for early stroke prediction after transient ischemic attack:the North Dublin TIA study显示文摘 | Sheehan OC Kyne L Kelly LA | 2010 | Stroke2010，41，： | 1 |
| 14 | Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events:the North Dublin TIA Study显示文摘 | Sheehan OC Merwick A Kelly LA | 2009 | Stroke2009，40，11： | 1 |
| 15 | National healthcare Safety Network(NHSN)report,data summary for 2006,through 2007,issued November 2008显示文摘 | Jonathan RE Kelly DP Mary LA | 2007 | AJIC2007，35，5： | 1 |
| 16 | Population-basedstudy of ABCD2 score, carotid stenosis, and atrial fibrilla-tion for early stroke prediction after transient ischemicattack: The North Dublin TIA Study 显示文摘 | Sheehan OC Kyne L Kelly LA | 2010 | Stroke2010，41，5： | 1 |
| 17 | Comparative tox- icity of citalopram and the newer antidepressants after o- verdose 显示文摘 | Kelly C A Dhaun N Laing W J | 2004 | J Toxicol Clin Toxicol2004，42，1： | 1 |
| 18 | Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study显示文摘 | Sheehan OC Merwick A Kelly LA | 2009 | Stroke2009，40，11： | 1 |
| 19 | Diagnostic useful- ness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study 显示文摘 | Sheehan OC Merwick A Kelly LA | 2009 | Stroke2009，40，11： | 1 |
| 20 | Systematic review:glucose control and cardiaovascular disease in type 2 diabetes显示文摘 | Kelly TN Bazzano LA Fonseca VA | 2009 | Annals of Internal Medicine2009，151，6： | 1 |
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