|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Structural testing of concurrent programs显示文摘 | Taylor R N Levine D L Kelly C D | 1992 | IEEE Trans Softw Eng1992，18，3： | 1 |
| 3 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 4 | Identification of XAF1 as an antagonist of XIAP anti-Caspase activity显示文摘 | LISTON P FONG W G KELLY N L | 2001 | Nat Cell Biol2001，3，2： | 1 |
| 5 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 6 | Clinical findingsand adverse outcome in neonates with symptomatic con-genital cytomegalovirus(SCCMV)infection显示文摘 | Kylat R I Kelly E N Ford-Jones E L | 2006 | Eur JPediatr2006，165，11： | 1 |
| 7 | Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy显示文摘 | Soranzo N Kelly L Martinian L | 2007 | Epilepsia2007，48，4： | 1 |
| 8 | Evapotranspiration covers: An innovative approach to remediate and close contaminated sites显示文摘 | KELLY L M DANIELLE N C RICHARD J W | 2003 | Remediation Winter2003，14，1： | 1 |
| 9 | A method for the use of landscape metrics in freshwater research and management显示文摘 | Kearns F R Kelly N M Carter J L | 2005 | Landscape Ecology2005，20，1： | 1 |
| 10 | Childhood stunting in relation to adolescent living environment and resili- ence:a follow up study in Lahore,Pakistan显示文摘 | Ekvall N Bengtsson L Kelly KB Mellander | 2003 | J Ayub Med Coil Abbottabad2003，15，1： | 1 |
| 11 | Transitory expression of alpha cardiac myosin heavy chain in a subpopulation of secondary generation muscle fibres in the pig显示文摘 | Lefaucheur L Hoffman R Okamura C Gerrard D Leger J J Rubinstein N Kelly A | 1997 | Developmental Dynamics1997，210，： | 1 |
| 12 | Effective thermal and elastic properties of ,Laminates 显示文摘 | MCCARTNEY L N KELLY A | 2007 | Composites Science and Technology2007，67，： | 1 |
| 13 | Temporal and spatial gain in stimulated light scattering显示文摘 | Kroll N M Kelly P L | 1971 | Phys Rev A1971，4，2： | 1 |
| 14 | 2005, A method for the use of landscape metrics in freshwater research and management 显示文摘 | KEARNS F R KELLY N M CARTER J L | 2005 | Landscape Ecology2005，20，1： | 1 |
| 15 | Zircon Tiny but Timely 显示文摘 | Harley S L Kelly N M | 2007 | Elements?2007，3，1： | 1 |
| 16 | Myeloid progenitor cells lacking p53exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation显示文摘 | Jabbour A M Daunt C P Green B D Vogel S Gordon L Lee R S Silke N Pearson R B Vandenberg C J Kelly P N Nutt S L Strasser A Borner C Ekert P G | 2010 | Blood2010，115，2： | 1 |
| 17 | A method for the use of landscape metrics in freshwater research and management 显示文摘 | Kearnsl F R Kelly N M Carter J L | 2005 | Landscape Ecology2005，20，： | 1 |
| 18 | Bayesian parameter estimation in probabilistic risk assessment 显示文摘 | Siu N O Kelly D L | 1998 | Reliability Engi and Syst Safety1998，62，： | 1 |
| 19 | Solar photovohaic charging of lithium-ion batteries显示文摘 | GIBSON T L KELLY N A | 2010 | Journal of Power Sources2010，195，12： | 1 |
| 20 | Effective thermal and elastic properties ofs Laminates显示文摘 | Mc Cartney L N Kelly A | 2007 | Composites Science and Technology2007，67，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员