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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Characterization Study of Diamond and Diamond-like Carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coating Technology1992，53，： | 2 |
| 3 | Concentrations and fluxes of dissolved biogenic gases (DMS,CH4,CO,CO2) in the equatorial Pacific during the SAGA-3 experiment显示文摘 | Bates T S Kelly K C Johnson J E | 1993 | J Geophys Res1993，98，16： | 1 |
| 4 | CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines 显示文摘 | Wang Y F Kelly C G Jaana T | 2001 | Immunity2001，15，6： | 1 |
| 5 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 6 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Optimal design for problems involving flow and transport phenomena in subsurface systems显示文摘 | Mayer A S Kelly C T Miller C T | 2002 | Advance in Water Resource2002，25，812： | 1 |
| 9 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 10 | Oxidative stress in toxicology:established mammalian and emerging piscine model systems显示文摘 | KELLY S A HAVRILLA C M BRADY T C | 1998 | Environ Health Perspect1998，106，7： | 1 |
| 11 | Phase II study of pemetrexed-gemcitabine combination in patients with advanced-stage non-small cell lung cancer显示文摘 | Monnerat C Le Chevalier T Kelly K | 2004 | Clin Cancer Res2004，10，16： | 1 |
| 12 | Oxidative stress in toxicology: Established mammalian and emerging piscine model systems 显示文摘 | Kelly S A Havrilla C M Brady T C et at | 1998 | Environmental Health Perspectives1998，106，7： | 1 |
| 13 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 14 | Rapid diversification of planktonic foraminifera in the tropica Pacific ( ODP Site 865) during the late Paleocene thermal maximum显示文摘 | Kelly D C Bralower T J Zachos J C | 1996 | Geology1996，24，： | 1 |
| 15 | Characterization study of diamond and diamond-like carbon显示文摘 | Dowling D P Ahern M J Kelly T C | 1992 | Surface and Coatings Technology1992，53，： | 1 |
| 16 | Effect of Elevated Temperature Exposure on Cast Gamma Titanium Aluminide (Ti-48Al-2Cr-2Nb) 显示文摘 | Kelly T J Austin C M Fink P J | 1994 | Scripta Metallurgica et Materialia1994，30，9： | 1 |
| 17 | Spectrophotometic Determination of Cysteine and/or Carbocysteine in a Mixture of Amino Acid,Shampoo,and Pharmaceutical Product Using p-Benzoquinone显示文摘 | Dimas A M Kelly C L Cassia T B V | 1999 | Talanta1999，50，5： | 1 |
| 18 | A Compressive Sensing and Unmixing Scheme for Hyperspectral Data Processing显示文摘 | Li C Sun T Kelly K | 2012 | IEEE Transactions on Image Process2012，21，3： | 1 |
| 19 | Fuzzy Logic Control of a Circular Cylinder Vortex Shedding Model显示文摘 | Stefan S Mchughlin T | 2003 | American Institute of Aeronautics and Astronautics2003，6，9： | 1 |
| 20 | An overview of research using the one atmosphere uniform glow discharge plasma (OAUGDP) for sterilisation of surfaces and materials 显示文摘 | Montie T C Kelly Wintenberg K Roth J R | 2000 | IEEE Trans on Plasma Sci2000，28，1： | 1 |
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