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| 1 | Radiation exposure and reduction in the operating room: Perspectives and future directions in spine surgery显示文摘Intraoperative imaging is vital for accurate placement of instrumentation in spine surgery. However, the use of biplanar fluoroscopy and other intraoperative imaging modalities is associated with the risk of significant radiation exposure in the patient, surgeon, and surgical staff. Radiation exposure in the form of ionizing radiation can lead to cellular damage via the induction of DNA lesions and the production of reactive oxygen species. These effects often result in cell death or genomic instability, leading to various radiation-associated pathologies including an increased risk of malignancy. In attempts to reduce radiation-associated health risks, radiation safety has become an important topic in the medical field. All practitioners, regardless of practice setting, can practice radiation safety techniques including shielding and distance to reduce radiation exposure. Additionally, optimization of fluoroscopic settings and techniques can be used as an effective method of radiation dose reduction. New imaging modalities and spinal navigation systems have also been developed in an effort to replace conventional fluoroscopy and reduce radiation doses. These modalities include Isocentric Three-Dimensional C-Arms, O-Arms, and intraoperative magnetic resonance imaging. While this influx of new technology has advanced radiation safety within the field of spine surgery, more work is still required to overcome specific limitations involving increased costs and inadequate training. | Ankur S Narain Fady Y Hijji Kelly H Yom Krishna T Kudaravalli Brittany E Haws Kern Singh | 2017 | World Journal of Orthopedics2017，8，7： | 9 |
| 2 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 3 | Effects of cultivation parameters on the morphology of Rhizopus arrhizus and the lactic acid production in a bubble column reactor显示文摘 | Zhang Z Y Jin B Kelly J M | 2007 | Engineering in Life Sciences2007，7，5： | 1 |
| 4 | CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines 显示文摘 | Wang Y F Kelly C G Jaana T | 2001 | Immunity2001，15，6： | 1 |
| 5 | Evaluation of endometrial receptivity during in - vitro fertilization using three - dimensional power Doppler ultrasound 显示文摘 | Jarvela I Y Slaskevicius P Kelly S | 2005 | Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology2005，26，7： | 1 |
| 6 | Biomimetic snowflake- shaped magnetic micro-/nanostructures for highly efficient adsorption of heavy metal ions and organic pollutants from aqueous solution显示文摘 | Zhang X M Liu J Y Kelly S J | 2014 | Journal of Materials Chemistry A2014，2，11： | 1 |
| 7 | Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70显示文摘 | Wang Y F Kelly C G Mahavir Singh | 2002 | J Immunol2002，169，5： | 1 |
| 8 | PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors显示文摘 | Yao Y Kelly MT Sajikumar S | 2008 | J Neurosci2008，28，31： | 1 |
| 9 | 3-D prestack reverse-time depth migration applied to vertical cableseismic data显示文摘 | Shen Y Valasek P Kelly K etal | 2000 | Expanded Abstracts of 70^th Annual Internat SEG Mtg2000，，： | 1 |
| 10 | MicroRNA signature distinguishes the degree of aggressiveness of papillary thyroid carcinoma 显示文摘 | Yip L Kelly L Shuai Y | 2011 | Ann Surg Oncol2011，18，7： | 1 |
| 11 | Impact of coal chlorine on mercury speciation and emission from a 100 MW utility boiler with cold-side electrostatic precipitators and low-NOx burners显示文摘 | CAO Y DUAN Y F KELLIE S | | 0，，3： | 1 |
| 12 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 13 | Green and competi- tive? An empirical test of the mediating role of environ- mental innovation strategy 显示文摘 | Eiadat Y Kelly A Roche F | 2008 | Journal of World Busi- ness2008，43，2： | 1 |
| 14 | Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer显示文摘 | Huang Y Wang S Kelly T | 2004 | Cancer Res2004，64，8： | 1 |
| 15 | Type interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (Pristane)显示文摘 | Nacionales D C Kelly K M Lee P Y | 2006 | AM J Pathol2006，168，4： | 1 |
| 16 | Breast feeding and in- tergenerational social mobility: what are the mechanisms显示文摘 | Sacker A Kelly Y Iacovou M | 2013 | Arch Dis Child2013，98，9： | 1 |
| 17 | Aliskiren, a novel renin inhibits, is nmolavtective in a model d advanced diabetic n~avlmthy in rats显示文摘 | Kelly DJ Zhang Y Moe G | 2007 | Diabetologia2007，50，11： | 1 |
| 18 | Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy显示文摘 | Mifsud S Kelly DJ Qi W Zhang Y Pollock CA Wilkinson-Berka JL | 2003 | Nephron Physiol2003，95，4： | 1 |
| 19 | siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain 显示文摘 | Senechal Y Kelly P John F | 2007 | Neurochemistry2007，102，6： | 1 |
| 20 | Prevalence and characteristics of adverse drug reactions in neurosurgical intensive care patients显示文摘 | Kelly MS Chad SJ Byron Y | 2006 | Neurosurgery2006，58，3： | 1 |
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