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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 3 | The treatment of earlymorning awakening insomnia with 2 evenings of bright light显示文摘 | Lack L Wright H Kemp K | 2005 | Sleep2005，28，5： | 1 |
| 4 | Distinct Amygdala-autonomic Arousal Profiles in Response to Fear Signals in Healthy Males and Females显示文摘 | WILLIAMS L M BARTON M J KEMP A H | 2005 | Neuroimage2005，，28： | 1 |
| 5 | Care of undocumented individuals with ESRD:a national survey of US nephrologists显示文摘 | Hurley L Kempe A Crane LA | 2009 | Am J Kidney Dis2009，53，6： | 1 |
| 6 | A nonmarine record of eccentricity forcing through the Upper Triassic of southwest England and its correlation with the Newark Basin astronomically calibrated geomagnetic polarity time scale from the North America 显示文摘 | Kemp D B Coe A L | 2007 | Geology2007，35，11： | 1 |
| 7 | Organic carbon and nitrogen in the surface sediments of lakes Ontario erie and Huron显示文摘 | Kemp A L W | 1971 | Journal of Sedimentary Research1971，41，2： | 1 |
| 8 | A defined serum-free medium useful for monitoring antimelanoma responses induced by dendritic cell immunotherapy显示文摘 | Bouwer A L Netter P Kemp R A | 2010 | Journal of Immunological Methods2010，352，12： | 1 |
| 9 | Creative commons : for the common good 显示文摘 | FORSYTHE L M KEMP D J | 2009 | University of La Veme Law Review2009，，30： | 1 |
| 10 | Loss of Fhit Is Frequent in Stage I Non-Small Cell Lung Cancer and in the Lungs of Chronic Smokers显示文摘 | Tseng J E Kemp B L Khuri F R | 1999 | Cancer Res1999，59，： | 1 |
| 11 | Reproductive tract infections and abortion among adolescent girls in rural Nigeria显示文摘 | Brabin L Kemp J Obunge OK | 1994 | Lancet1994，344，1： | 1 |
| 12 | Distribution and forms of nitrogen in a Lake Ontario sediment core显示文摘 | Kemp A L W Mudrochova A | 1972 | Limnology and Oceanography1972，17，6： | 1 |
| 13 | Femtosecond Yb:YCOB laser pumped by narrow-stripe diode and passively mode locked using ion implanted saturable-absorber mirror 显示文摘 | VALENTINE G J KEMP A J B1RK1N D J L | 2000 | Electron Left2000，36，19： | 1 |
| 14 | Substance abuse and polyhdramnios显示文摘 | Kemp AP N guyen T Casteo L | 2002 | Am J Obstet Gynecol2002，187，： | 1 |
| 15 | Tenderness-an enzymatic view显示文摘 | KEMP C M SENSKY P L BARDSLEY R G | | 0，，02： | 1 |
| 16 | Loss of FHIT is frequent in stage I non- small cell lung cancer and in the lungs of chronic smokers 显示文摘 | TSENG J E KEMP B L KHURI F R | 1999 | Cancer Res1999，59，10： | 1 |
| 17 | Loss of Fhit is frequent in stage Ⅰ non-small cell lung cancer and in the lungs of chronic smokers显示文摘 | Tseng J E Kemp B L Khuri F R | | 0，，19： | 1 |
| 18 | Residue analysis of 500 high priority pesticides:better by GC-MS or LC-MS/MS显示文摘 | ALDER L GREULICH K KEMPE G VIETH B | 2006 | Mass Spectrom Rev2006，25，1： | 1 |
| 19 | Expression of DMBT1,a candidate tumor suppressor gene,is frequently lost in lung cancer显示文摘 | Wu W Kemp BL Proctor M L | 1999 | Cancer Res1999，59，8： | 1 |
| 20 | The mechanism of bacterial reduction of sulfate and of sulphite from isotope fractionation studies显示文摘 | Kemp A L Thode H G | 1968 | Geochi mica et Cos mochi mica Acta1968，32，： | 1 |
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