| 1 | Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells显示文摘As one of the adjuvant treatments for cancer treatment,traditional Chinese medicine treatment has a wide range of cancer treatments,such as preventing metastasis and relapse,improving the efficacy of radiotherapy and chemotherapy,reducing the side effects of chemotherapy,improving body function,extending life and improving the life quality.Geniposide(GEN)is a bioactive substance extracted from the fruit of gardenia.In recent years,it has attracted attention due to its anti-tumor effect.In this study,we aimed to investigate whether GEN could inhibit the proliferation of human breast cancer cells(MCF-7)and promote its apoptosis.The half-inhibitory concentration(IC50)values of GEN were firstly determined as 16.06,14.85 and 13.14 mg/mL by the CCK-8 experiment after cells treated for 24 h,48 h,and 72 h,respectively.The inhibitory effect of GEN on MCF-7 cells was in concentration-and time-dependent manners from the results of CCK-8 experiment and Live/Dead staining.AO/EB staining result has shown that GEN has induced MCF-7 cell apoptosis. | Kena Lv Shuangshuang Zheng Xiangqin Li Yi Nie Tianqing Liu Kedong Song | 2020 | Molecular & Cellular Biomechanics2020，17，4： | 1 |
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