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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 4 | The mental health of UK Gulfwar veterans:phase 2 of a two phase cohort study显示文摘 | Ismail K Kent K Brugha T | 2002 | BMJ2002，325，7364： | 1 |
| 5 | Commutation Failures in HVDC Transmission Systems显示文摘 | THIO C V DAVIES J B KENT K L | | 0，，02： | 1 |
| 6 | Frequently Asked Questions about Microbiologically Influenced Corrosion(MIC ) 显示文摘 | Kent R K Fitz M M Cline K G | 2004 | Forensic Eengineering and Laboratories2004，35，4： | 1 |
| 7 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 8 | Novel, high-frequency, low-strain mechanical loading for premenopausal women with low bone mass: early findings 显示文摘 | Bech BR Kent K Holloway L | 2006 | J Bone Miner Metab2006，24，6： | 1 |
| 9 | The effect of vaccination against Porcine reproductive and respiratory syndrome virus (PRRSV) on the Porcine circo- virus-2 (PCV-2) load in porcine circovirus associated disease (PCVAD) affected pigs显示文摘 | Genzow Marika/M Schwartz Kent/K Gonzalez Glenda/G | 2009 | Can J Vet Res2009，3，2： | 1 |
| 10 | Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer显示文摘 | YUAN Z SOTSKY KENT T WEBER T K | 2003 | Oncogene2003，22，40： | 1 |
| 11 | Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver 显示文摘 | Forgacs Agnes L Kent Michael N Makley Meghan K | 2012 | Toxicol Sci2012，125，： | 1 |
| 12 | Security Architecture for the lnternet Protocol显示文摘 | SEO K KENT S | 2005 | 2005，，： | 1 |
| 13 | Commutation failures in HVDC transmission systems显示文摘 | THIO C V DAVIES J B KENT K L | 1996 | IEEE Transactions on Power De- livery1996，11，2： | 1 |
| 14 | Endovascular repair compared with surveillance for patients with small abdominal aortic aneurysm显示文摘 | Ouriel K Clair DG Kent KC | 2010 | J Vasc Surg2010，51，5： | 1 |
| 15 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Transactions on Power Delivery1996，11，2： | 1 |
| 16 | Seed banks as a neglected area of biogeographic research: A review of literature and sampling techniques显示文摘 | Warr S J Thompson K Kent M | 1993 | Progess in Physical Geography1993，17，： | 1 |
| 17 | Alfalfa root exudates and compounds which promote or inhibition induce of rhizobium melilot nodulation genes显示文摘 | Kent N K | 1988 | Plant Physiology1988，，90： | 1 |
| 18 | Using FPGAs to solve the Hamihonian cycle problem显示文摘 | SERRA M KENT K | 2003 | Circuits and systems2003，3，： | 1 |
| 19 | An adaptive kalman filter for dynamic harmonic state estimation and harmonic injection tracking显示文摘 | Kent K C Y Watson N R Arrillaga J | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 20 | Commutation failures in HVDC transmission, systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
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