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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity显示文摘 | Ramsay A J Kent S J Strugnell R A | 1999 | Immunol Rev1999，171，1： | 1 |
| 4 | Behavior and design of reinforced concrete, steel, and steel-concrete coupling beams显示文摘 | KENT A HARRIES M EERI BINGNIAN GONG BAHRAM M SHAHROOZ | 2000 | Earthquake Spectra2000，16，4： | 1 |
| 5 | Functional grading of mineral and collagen in the attachment of tendon to bone 显示文摘 | Genin GM Kent A Birman V | 2009 | Biophys J2009，97，： | 1 |
| 6 | Memory At- tack on Device-Independent Quantum Cryp- tography显示文摘 | BARRETT J COLBECK R KENT A | 2013 | Physical Review Letters2013，110，01： | 1 |
| 7 | Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus显示文摘 | Kent SJ Zhao A Best SJ | | 0，，： | 1 |
| 8 | Diagnosing autism spectrum disorder:who will get a DSM-5 diagnosis?显示文摘 | Kent RG Carrington SJ Le Couteur A | 2013 | J Child Psychol Psychiatry2013，54，11： | 1 |
| 9 | Modulation of CDK2-AP1 (p12(DOC-1))expression in human colorectal cancer显示文摘 | YUAN Z GABA A G KENT T S | 2005 | Oncogene2005，24，： | 1 |
| 10 | Full-scale experimental investigation of repair of reinforced concrete interstate bridge using CFRP materials 显示文摘 | Aidoo John Harries Kent A Petrou Michael F | 2006 | Journal of Bridge Engineering2006，11，3： | 1 |
| 11 | Private randomness expansion with untrusted devices显示文摘 | Colbeck R Kent A | 2011 | Journal of Physics A Mathematical and Theoretical2011，44，09： | 1 |
| 12 | Web-based phylogenetic assignment tool for analysis of terminal restriction fragment length polymorphism profiles of microbial communities显示文摘 | Kent A D Smith D J Benson B J | 2003 | Applied and Environmental Microbiology2003，69，11： | 1 |
| 13 | Definiing regions of the Y - chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y - chromosome microdeletion detection显示文摘 | Kent - First M Muallem A SchultzJ | 1999 | Mol Reprod Dev1999，53，： | 1 |
| 14 | Defining regionsof the Yechromosome responsible formale infertility and identification of a fourthAZFregion(AZFd) by Y chromo some micro deletion detection显示文摘 | Kent First M Muallem A Shuhz J | 1999 | MolReprod Dev1999，53，1： | 1 |
| 15 | Microbial community structure and denitrification in a wetland mitigation bank 显示文摘 | electrophoresis analysis of electrophoresis ( TGGE ) in Per'alta A L Matthews J W Kent A D | 2010 | Appl Environ Microbiol2010，76，13： | 1 |
| 16 | Mississippian Barnett Shale,Fort Worth basin,north-central Texas:Gas-shale play with multi-trillion cubic foot potential显示文摘 | Scott L Montgomery Daniel M Jarvie Kent A Bowker | | 0，，02： | 1 |
| 17 | Treatment of hyperglycemia in is- chemic stroke (THIS) : a randomized pilot trial 显示文摘 | Bruno A Kent TA Coull BM | 2008 | Stroke2008，39，： | 1 |
| 18 | Defining regions of the Y chromosome responsible for male infertility and identification of afourth AZF region (AZFd) by Y chromosome microdeletion detection 显示文摘 | Kent - First M Muallem A Shultz J | 1999 | Mol Rep rod Dev1999，53，1： | 1 |
| 19 | The impact of childhood emotional abuse: an extension of the child buse and trauma scale 显示文摘 | Kent A Waller G | 1998 | Child Abuse & Neglect1998，22，： | 1 |
| 20 | Full polarimetric calibration for radar cross-section measurements:Performance analysis显示文摘 | Welsh B M Kent B M Buterbaugh A L | 2004 | IEEE Trans on AP2004，52，9： | 1 |
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