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| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | Performance Appraisals: Usage, Criteria and Obserbations显示文摘 | Pettijohn L S Stephen Parker R Pettijohn C E Kent J L | 2001 | Journal of Management Development2001，20，9： | 1 |
| 3 | Electrolytically ac- tivqted contractile polymers 显示文摘 | Hamlen R P Kent C E Sharer S N | 1965 | Nature1965，206，： | 1 |
| 4 | 显示文摘 | Hamlem R P Kent C E Shafer S N | 1965 | Nature1965，206，： | 1 |
| 5 | The ac- curacy of wind observations from ships显示文摘 | TAYLOR P K KENT E C YELLAND M J | 1995 | Advances in the Applications of Marine Climatology1995，2，2： | 1 |
| 6 | Wind stress forcing of the ocean in the SOC climatology: comparisons with the NCEP-NCAR, ECMWF, UWM/COADS, and Hellerman and Rosenstein datasets 显示文摘 | JOSEY S A KENT E C TAYLOR P K | 2002 | Journal of Physical Oceanography2002，32，： | 1 |
| 7 | Knowledge acquisition from foreign parents in international joint ventures: An empirical study in Vietnam显示文摘 | PHAN T A BAUGHN C C NGO T M H KENT E N | 2006 | International Business Review2006，，15： | 1 |
| 8 | Facial asymmetry while posing positive and negative emotions:Support for the right hemisphere hypothesis显示文摘 | Borod J C Kent J Koff E | | 0，，05： | 1 |
| 9 | The patient with hormone refractory protate cancer: determining who, when and how to treat显示文摘 | Kent E C Hussain M H A | 2003 | Urology2003，62，： | 1 |
| 10 | BioMagResBank显示文摘 | Ulrich E L Akutsu H Doreleijers J F Harano Y Ioannidis Y E Lin J Livny M Mading S Maziuk D Miller Z Nakatani E Schulte C F Tolmie D E Kent Wenger R Yao H Markley J L | | 0，，1： | 1 |
| 11 | Post-laryngectomypharyngocutaneous flstulae显示文摘 | Kent S E Liu K C DasGupta A R | 1985 | J Laryngol Otol1985，99，5： | 1 |
| 12 | Facial asymmetry while posing positive and negative emotions:Support for the right hemisphere hypothesis显示文摘 | Borod J C Kent J Koff E | | 0，，05： | 1 |
| 13 | Bioaccumulation and clearance of microcystins from salt water mussels, Mytilus edulis, and in vivo evidence for covalently bound microcystins in mussel tissues 显示文摘 | Williams D E Dawe S C Kent M L | 1997 | Toxicon1997，35，： | 1 |
| 14 | Neocortical neural sprouting,synaptogenesis,and behavioral recovery after neocortical infarction in rats显示文摘 | STROEMER R P KENT T A HULSEBOSCH C E | 1995 | Stroke1995，26，： | 1 |
| 15 | Growth and or- ganized development of cultured cells显示文摘 | Steward F C Mapes M O Kent A E | 1958 | American Journal of Botany1958，45，： | 1 |
| 16 | Ascent of dinosaurs linked to an iridium anomaly at the Triassic-Jurassic boundary显示文摘 | Olsen P E Kent D V Sues H D Koeberl C Huber H Monlanari A Rainforth E C Fowell S J Szajna M J Hartline B W | 2002 | Science2002，296，5571： | 1 |
| 17 | Transactivation of miR-34a by p53 broadly influences gene expression and promotes apeptosis显示文摘 | Chang T C Wentzel E A Kent O A | 2007 | Mo] Ce112007，26，5： | 1 |
| 18 | Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women显示文摘 | Teresa S.M Tsang Bernard J Gersh Christopher P Appleton A.Jamil Tajik Marion E Barnes Kent R Bailey Jae K Oh Cynthia Leibson Samantha C Montgomery James B Seward | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 19 | Neocortical neural sprouting, synaptogenesis and behavioral recovery after neocortical infarction in rats 显示文摘 | STROEMER R P KENT T A HULSEBOSCH C E | 1995 | Stroke1995，26，11： | 1 |
| 20 | Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates显示文摘 | Jacob E Steiner Dieter Glaser Maria E Hawilo Kent C Berridge | 2001 | Neuroscience and Biobehavioral Reviews2001，，1： | 1 |
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