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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Load regulation of the properties of adult feline cardiocytes: growth induction by cellular deformation显示文摘 | Mann D L Kent R L Cooper G | 1989 | Circ Res1989，64，6： | 2 |
| 3 | Convergecne spaces and diagonal conditions显示文摘 | Kent D C Richardson G D | 1996 | Topology and its Applications1996，70，： | 1 |
| 4 | Frequently Asked Questions about Microbiologically Influenced Corrosion(MIC ) 显示文摘 | Kent R K Fitz M M Cline K G | 2004 | Forensic Eengineering and Laboratories2004，35，4： | 1 |
| 5 | Modulation of CDK2-AP1 (p12(DOC-1))expression in human colorectal cancer显示文摘 | YUAN Z GABA A G KENT T S | 2005 | Oncogene2005，24，： | 1 |
| 6 | Chemical protein synthesis显示文摘 | Kochendoerfer G G Kent S B H | 1999 | Curr Opin Chem Biol1999，3，6： | 1 |
| 7 | The effect of vaccination against Porcine reproductive and respiratory syndrome virus (PRRSV) on the Porcine circo- virus-2 (PCV-2) load in porcine circovirus associated disease (PCVAD) affected pigs显示文摘 | Genzow Marika/M Schwartz Kent/K Gonzalez Glenda/G | 2009 | Can J Vet Res2009，3，2： | 1 |
| 8 | Trends in the diagnosis and treatment of ectopic pregnancy in the united slates显示文摘 | Hoover Kw Tao G Kent CK | 2010 | Obstet Gynecol2010，115，3： | 1 |
| 9 | Statistical models of F2slope in relation to severity of dysarthria显示文摘 | Kim Y Weismer G Kent RD | 2009 | Folia Phoni-atr Logo2009，61，6： | 1 |
| 10 | Against pragmatism: on effica- cy, effectiveness and the real world显示文摘 | Kent D M Kitsios G | 2009 | Trials2009，10，： | 1 |
| 11 | The impact of childhood emotional abuse: an extension of the child buse and trauma scale 显示文摘 | Kent A Waller G | 1998 | Child Abuse & Neglect1998，22，： | 1 |
| 12 | Distribution and parti- tioning of trace metals (Cd, Cu, Ni, Pb, Zn) in Galveston Bay waters 显示文摘 | Tang D G Kent W W Peter H S | 2002 | Marine Chemistry2002，78，5： | 1 |
| 13 | Pumping equipment for offshoredeep water & marginal oilfields显示文摘 | VANCE W KENT G | 2001 | World Pumps2001，419，： | 1 |
| 14 | High - resolution DNA melting analysis for simple and efficient molecular diagnostics 显示文摘 | REED G H KENT J O WITYWER C T | 2007 | Pharmacoengenomios2007，8，6： | 1 |
| 15 | Trends in the diagnosis and treatment of ectopic pregnancy in the United States显示文摘 | Hoover KW Tao G Kent CK | 2010 | Obstetrics and gynecology2010，115，3： | 1 |
| 16 | Relationship between bleeding time test and postextraction bleeding in a healthy control population 显示文摘 | Brennan MT Shariff G Kent ML | 2002 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002，94，： | 1 |
| 17 | Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer:2010 update by the infectious diseases society of america显示文摘 | Alison G F Eric J B Kent A S | | 0，，04： | 1 |
| 18 | The effect of quench rate on the microstructure and stress corrosionresistance of a weldable Al-Zn-Mg alloy显示文摘 | Kent K G | 1969 | J Inst Metals1969，97，4： | 1 |
| 19 | A structured model for penicillin production on mixed substrates显示文摘 | PAUL G C SYDDALL M T KENT C A | 2001 | Biochemical Engineering Journal2001，7，： | 1 |
| 20 | Herpes simplex virus latency-associated transcript gene function 显示文摘 | Jennifer R Kent Wen Kang Cathie G Miller | 2003 | Journal of Neuro Virology2003，9，： | 1 |
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