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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 3 | Dietary copper requirement reevaluation for juvenile grouper,Epinephelus malabaricus,with an organic copper source显示文摘 | Lin Y H Shih C C Kent M | 2010 | Aquaculture2010，310，1： | 1 |
| 4 | Mycobacteriosis in zebrafish ( Danio rerio ) research facilities 显示文摘 | Kent M L Whipps C M Matthews J L | 2004 | Comparative Biochemistry and Physiology Part C2004，138，： | 1 |
| 5 | Minimally invasive resection of benign esophageal tumors 显示文摘 | Kent M D'Amato T Nordman C | 2007 | J Thorac Car Diovasc Surg2007，134，1： | 1 |
| 6 | Three-field lymph node dissection for squamous adenocarcinoma of the esophagus显示文摘 | Ahorki N Kent M Ferrara C | 2002 | Ann Surg2002，236，2： | 1 |
| 7 | A structured model for penicillin production on mixed substrates显示文摘 | PAUL G C SYDDALL M T KENT C A | 2001 | Biochemical Engineering Journal2001，7，： | 1 |
| 8 | Three-field lymph node dissection for squamous cell carcinoma and adenocarcino- ma of the esophagus显示文摘 | Ahorki N Kent M Ferrara C | 2002 | Ann Surg2002，236，2： | 1 |
| 9 | The Russel - Yasuda Kasai model : an asset/liability model for a Japanese insurance company using multi - stage stochastic programming 显示文摘 | Carino D R Kent T Mayers D H Stacy C Sylvanus M Turner A Watanabe K Ziemba W T | 1994 | Interfaces1994，24，： | 1 |
| 10 | Carbon clusters near the crossover to fullerene stability显示文摘 | Kent P R C Towler M D Needs R J | 2000 | Phys Rev B2000，62，15： | 1 |
| 11 | The ac- curacy of wind observations from ships显示文摘 | TAYLOR P K KENT E C YELLAND M J | 1995 | Advances in the Applications of Marine Climatology1995，2，2： | 1 |
| 12 | Prospective highlights of functional skin proteomics显示文摘 | Huang C M Elmets C A Kampen kent R V | | 0，，： | 1 |
| 13 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 14 | Knowledge acquisition from foreign parents in international joint ventures: An empirical study in Vietnam显示文摘 | PHAN T A BAUGHN C C NGO T M H KENT E N | 2006 | International Business Review2006，，15： | 1 |
| 15 | The patient with hormone refractory protate cancer: determining who, when and how to treat显示文摘 | Kent E C Hussain M H A | 2003 | Urology2003，62，： | 1 |
| 16 | BioMagResBank显示文摘 | Ulrich E L Akutsu H Doreleijers J F Harano Y Ioannidis Y E Lin J Livny M Mading S Maziuk D Miller Z Nakatani E Schulte C F Tolmie D E Kent Wenger R Yao H Markley J L | | 0，，1： | 1 |
| 17 | Three-field lymph node dissection for squamous cell and adenocareinoma of the esophagus 显示文摘 | ALTORKI N KENT M FERRARA C | 2002 | Ann Surg2002，236，2： | 1 |
| 18 | Effects of neonatal capsaicin administration on the numbers and volumes of neurons in left and right T10 dorsal root ganglia in the rat 显示文摘 | McCarthy M Kent C Mayhew T M | 1999 | J Neurocytol1999，28，2： | 1 |
| 19 | 显示文摘 | KENT K M POSTIVH M J | 1998 | J Org Chem1998，63，13： | 1 |
| 20 | Understanding construction industry experience and attitudes toward integrated project delivery 显示文摘 | David C Kent S M Asce Burcin Becerik-Gerber | 2010 | Journal of Construction Engineering and Management2010，136，8： | 1 |
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