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15篇 您的检索式：作者名="Kent MJ"

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		题名	作者	年代	出处	被引量
	1	Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption.	Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe	2015	Bone Research2015，3，4：	2
	2	Oral administration of myelin induces antigen-specific TGF-betal secreting T cells in patients with multiple sclerosis显示文摘	Hailer DA Kent SC Pietrusewicz MJ	1997	Ann NY Acad Sci1997，835，19：	1
	3	Unilateral breast masses in men over40:a diagnostic dilemma显示文摘	O'Hanlon DM Kent P Kerin MJ	1995	Am J Surg1995，170，：	1
	4	Practical synthesis of the anti-influenza drug GS-4104 显示文摘	Kent KM Postich MJ	1998	J Org Chem1998，63，13：	1
	5	Phesphatidylinesitol 3 kinase mod- ulation of trophoblast cell differentiation 显示文摘	Kent LN Konno T Soares MJ	2010	BMC Dev Bid2010，，10：	1
	6	Postmortem proteolysis is reduced in transgenie mice overexpressing calpastatin显示文摘	Kent MP Spencer MJ Koohmaraie M	2004	J Anita Sci2004，82，3：	1
	7	Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-betal-secreting Th3 T cells by oral administration of myelin in multiple scleresis patients显示文摘	Fukaura H Kent SC Pietrusewicz MJ	1996	J Clin Invest1996，98，1：	1
	8	Postmortem proteolysis is reduced in transgenic mice overexpressing ealpastatin 显示文摘	Kent MP Spencer MJ Koohmaraie M	2004	J Anita Sci2004，82，3：	1
	9	Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T ceils in patients with multiple sclerosis显示文摘	Hailer DA Kent SC Pietrusewiez MJ	1997	Ann N Y Acad Sei1997，19，835：	1
	10	Life-threatening parane- oplastic syndrome in a child with sarcoma of the liver cured by emergency resection显示文摘	Fricchione MJ Glenn N Follmer R Kent PM	2013	J Pediatr Hematol Oncol2013，35，：	1
	11	An evaluation of preoperative CA15-3 measurement in primary breast carcinoma显示文摘	O′Hanlon DM Kerin MJ Kent P	1995	Br J Cancer1995，71，6：	1
	12	Management of diabetes mellitus in the Lovelace Health Systems EPISODES OF CARE program显示文摘	Friedman NM Gleeson JM Kent MJ	1998	Eff Clin Pract1998，1，1：	1
	13	Does targeting manual therapy and/or exercise improve patient outcomes in nonspecific low back pain? A systematic review显示文摘	Kent P Mj(o)sund HL Petersen DH	2010	BMC Med2010，8，8：	1
	14	Evidence for glucose-me-diated covalent cross-linking of collagen after glycosylationin vitro显示文摘	Kent MJ Light ND Bailey AJ	1985	Biochem J1985，225，3：	1
	15	Practical total synthesis of the anti-influenza drug GS-4104显示文摘	Rchloff JC Kent KM Postich MJ	1998	J Org Chem1998，63，13：	1

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