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| 1 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 2 | Cutaneous metastasis as an initial presentation of a non-functioning pancreatic neuroendocrine tumor显示文摘Non-functioning pancreatic neuroendocrine tumors(NF-PNETs) are rare tumors that account for 2% of all pancreatic malignancy.About 60% of NF-PNETs present distant metastases and usually hepatic metastases.However,cutaneous metastases are very rare.Herein,we report our experience with a 60-yearold male who visited our outpatient clinic with a mass on his left hip.An abdominal computerized tomography scan demonstrated not only a left hip mass and an enlarged left inguinal lymph node,but also a huge heterogeneous enhancing mass on the pancreas.Initially,we removed the metastatic lesions,which was a small cell neuroendocrine carcinoma with 50% of the Ki-67 index in the histopathological report.After 3 wk,we performed a total pancreatectomy and a total gastrectomy.Four weeks after the 1st operation,we detected a recurrence at the operative bed on his left hip,and subsequently removed the recurring mass.The patient was receiving chemotherapy based on etoposide and cisplatin treatment. | Woo Young Shin Keon Young Lee Seung Ik Ahn Shin-Young Park Keun-Myoung Park | 2015 | World Journal of Gastroenterology2015，21，33： | 4 |
| 3 | Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry)显示文摘ObjectivesTo 评估年龄相关的一个年专业在在尖锐心肌的梗塞(AMI ) 的经皮的冠的干预(一种总线标准) 以后的不利 cardiocerebrovascular 事件(MACCE ) 。我们从在 2011 年 11 月之间的健康(KAMIR-NIH ) 的朝鲜尖锐心肌的梗塞登记公民 Institue 在 13,104 个 AMI 病人全部的 AMI.MethodsA 以后分析了在年龄和一个年 MACCE 之间的协会, 2015 年 12 月根据年龄被分类进四个组(组我, < 60 年, n = 4199;组 II, 60-70 年, n = 2577;组织 III;70-80 年, n = 2774;组 IV, 80 年, n = 1018 ) 。病人们为 MACCE 合成的一个年被分析(心脏的死亡,心肌的梗塞,目标容器 revascularization,脑血管的事件) 在 AMI.ResultsThe 一个年以后,在 AMI 的 MACCE 是 3.5%( 组我) , 6.3%( 组 II ) , 9.6%( 组 III ) 并且 17.6%( 组 IV ) 。在为使参数惊讶的调整以后,分析结果证明有 AMI 的病人有一个年 MACCE 的增长风险[组 II,调整危险比率(aHR )= 1.224, 95% CI:0.965-1.525, P = 0.096;组 III, aHR = 1.316, 95% CI:1.037-1.671, P = 0.024;组 IV, aHR = 1.975, 95% CI:1.500-62.601, P < 0.001 ) 与相比组我。特别,心脏的死亡在玩的主要结束点合成在这效果的一个主要角色(组 II, aHR = 1.335, 95% CI:0.941-1.895, P = 0.106;组 III, aHR = 1.575, 95% CI:1.122-2.210, P = 0.009;组 IV, aHR = 2.803, 95% CI:1.937-4.054, P < 0.001 ).ConclusionsDespite 在 AMI 为一种总线标准推进了技术和药,年龄仍然在临床的结果施加强大的影响。小心的途径,甚至在发达心病学的现代时代被需要为在 AMI 干预年老人口。 | Dae-Won Kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung Chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung | 2018 | Journal of Geriatric Cardiology2018，15，9： | 4 |
| 4 | Statistical Prediction of Heavy Rain in South Korea显示文摘This study is aimed at the development of a statistical model for forecasting heavy rain in South Korea. For the 3-hour weather forecast system, the 10 km × 10 km area-mean amount of rainfall at 6 stations (Seoul, Daejeon, Gangreung, Gwangju, Busan, and Jeju) in South Korea are used. And the corresponding 45 synoptic factors generated by the numerical model are used as potential predictors. Four statistical forecast models (linear regression model, logistic regression model, neural network model and decision tree model) for the occurrence of heavy rain are based on the model output statistics (MOS) method. They are separately estimated by the same training data. The thresholds are considered to forecast the occurrence of heavy rain because the distribution of estimated values that are generated by each model is too skewed. The results of four models are compared via Heidke skill scores. As a result, the logistic regression model is recommended. | Keon Tae SOHN Jeong Hyeong LEE Soon Hwan LEE Chan Su RYU | 2005 | Advances in Atmospheric Sciences2005，22，5： | 3 |
| 5 | Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry显示文摘Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up. | Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung 无 KAMIR-NIH registry investigators | 2020 | Journal of Geriatric Cardiology2020，17，11： | 3 |
| 6 | Memory-centric neuromorphic computing for unstructured data processing显示文摘The unstructured data such as visual information,natural language,and human behaviors opens up a wide array of opportunities in the field of artificial intelligence(Al).The memory-centric neuromorphic computing(MNC)has been proposed for the efficient processing of unstructured data,bypassing the von Neumann bottleneck of current computing architecture.The development of MNC would provide massively parallel processing of unstructured data,realizing the cognitive Al in edge and wearable systems.In this review,recent advances in memory-centric neuromorphic devices are discussed in terms of emerging nonvolatile memories,volatile switches,synaptic plasticity,neuronal models,and memristive neural network. | Sang Hyun Sung Tae Jin Kim Hera Shin Hoon Namkung Tae Hong Im Hee Seung Wang Keon Jae Lee | 2021 | Nano Research2021，14，9： | 3 |
| 7 | The Effects of Aroma Acupuncture applied on Chronic Headache Patients显示文摘 | In Tae JUNG Su Yong KIM Doo Ik LEE Keon Sik KIM Jae Dong LEE Yun Ho LEE Do Young CHOI | 2005 | World Journal of Acupuncture-Moxibustion2005，15，3： | 2 |
| 8 | Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues显示文摘 | Keon Hee Yoo In Keun Jang Myoung Woo Lee Hyo Eun Kim Mal Sook Yang Youngwoo Eom Jong Eun Lee Young Jin Kim Seong Kyu Yang Hye Lim Jung Ki Woong Sung Cheol Woo Kim Hong Hoe Koo | 2009 | Cellular Immunology2009，，2： | 2 |
| 9 | Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells显示文摘Background: Autophagy is elevated in metastatic tumors and is often associatedwith active epithelial-to-mesenchymal transition (EMT). However, the extent towhich EMT is dependent on autophagy is largely unknown. This study aimed toidentify the mechanisms by which autophagy facilitates EMT.Methods: We employed a liquid chromatography-based metabolomic approachwith kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1)gene co-mutated (KL) cells that represent an autophagy/EMT-coactivatedinvasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation. Molecular mechanisms of autophagy-drivenEMT activation were further investigated by quantitative real-time polymerasechain reaction (qRT-PCR), Western blotting analysis, immunoprecipitation,immunofluorescence staining, and metabolite assays. The effects of chemicaland genetic perturbations on autophagic flux were assessed by two orthogonalapproaches: microtubule-associated protein 1A/1B-light chain 3 (LC3) turnoveranalysis by Western blotting and monomeric red fluorescent protein-greenfluorescent protein (mRFP-GFP)-LC3 tandem fluorescent protein quenchingassay. Transcription factor EB (TFEB) activity was measured by coordinatedlysosomal expression and regulation (CLEAR) motif-driven luciferase reporterassay. Experimental metastasis (tail vein injection) mouse models were used toevaluate the impact of calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVISluciferase imaging system.Results: We found that autophagy in KL cancer cells increased acetyl-coenzymeA (acetyl-CoA), which facilitated the acetylation and stabilization of theEMT-inducing transcription factor Snail. The autophagy/acetyl-CoA/acetylSnail axis was further validated in tumor tissues and in autophagy-activatedpancreatic cancer cells. TFEB acetylation in KL cancer cells sustained prometastatic autophagy in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner. Pharmacological inhibition of this axis via CAMKK2inhibitors or ACLY inhibitors consistently reduced the metastatic capacity of KLcancer cells in vivo.Conclusions: This study demonstrates that autophagy-derived acetyl-CoA promotes Snail acetylation and thereby facilitates invasion and metastasis of KRASLKB1 co-mutated lung cancer cells and that inhibition of the autophagy/acetylCoA/acetyl-Snail axis using CAMKK2 or ACLY inhibitors could be a potentialtherapeutic strategy to suppress metastasis of KL lung cancer. | Jang Hee Han Yong Keon Kim Hakhyun Kim Jooyoung Lee Myung Joon Oh Sang Bum Kim Minjee Kim Kook Hwan Kim Hyun Ju Yoon Myung-Shik Lee John D.Minna Michael A.White Hyun Seok Kim | 2022 | Cancer Communications2022，42，8： | 2 |
| 10 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 11 | Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction显示文摘Chronic ethanol consumption is well established as a major risk factor for type-2 diabetes(T2D), which is evidenced by impaired glucose metabolism and insulin resistance. However, the relationships between alcoholconsumption and the development of T2 D remain controversial. In particular, the direct effects of ethanol consumption on proliferation of pancreatic β-cell and the exact mechanisms associated with ethanolmediated β-cell dysfunction and apoptosis remain elusive. Although alcoholism and alcohol consumption are prevalent and represent crucial public health problems worldwide, many people believe that low-tomoderate ethanol consumption may protect against T2 D and cardiovascular diseases. However, the J- or U-shaped curves obtained from cross-sectional and large prospective studies have not fully explained the relationship between alcohol consumption and T2 D. This review provides evidence for the harmful effects of chronic ethanol consumption on the progressive development of T2 D, particularly with respect to pancreatic β-cell mass and function in association with insulin synthesis and secretion. This review also discusses a conceptual framework for how ethanolproduced peroxynitrite contributes to pancreatic β-cell dysfunction and metabolic syndrome. | Ji Yeon Kim Dae Yeon Lee Yoo Jeong Lee Keon Jae Park Kyu Hee Kim Jae Woo Kim Won-Ho Kim | 2015 | World Journal of Biological Chemistry2015，6，1： | 2 |
| 12 | A comparsion of intracellular solution for donor heart preservation显示文摘 | Labow RS Keon WJ | 1993 | J Thorac Cardiovasc Surg1993，105，： | 1 |
| 13 | Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation显示文摘 | Hyung GyunKim Tran ThiHien Eun HeeHan Yong PilHwang Jae HoChoi Keon WookKang Kwang‐ilKwon Bong‐HeeKim Sang KyumKim Gye YongSong Tae CheonJeong Hye GwangJeong | 2011 | British Journal of Pharmacology2011，，5： | 1 |
| 14 | Sintering of Mixed UO2 and U308 Powder Compacts显示文摘 | Kun Woo Song Keon Sik Kim Young Min Kim | 2000 | Journal of Nuclear Materials2000，277，： | 1 |
| 15 | The therapeutic potential of 4-1BB(CD147) in cancer显示文摘 | Nam K O Kang W J Keon B S | 2005 | Current Cancer Drug Targets2005，5，： | 1 |
| 16 | The wheat mitogen-activated protein kinases TaMPK3 and TaMPK6 are differentially regulated at multiple levels during compatible disease interactions with Mycosphaerella graminicola显示文摘 | Rudd J J Keon J Hammond-Kosack K E | | 0，，： | 1 |
| 17 | Distributed localization in wireless sensor networks: aquantitative comparison 显示文摘 | Langendoen Keon Reijiers Niels | 2003 | Computer Networks2003，43，4： | 1 |
| 18 | Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host显示文摘 | Keon J Antoniw J Carzaniga R | 2007 | Mol Plant-Microbe Interact2007，20，2： | 1 |
| 19 | The wheat mitogen-activated protein kinases TaMPK3 and TaMPK6 are differentially regulated at multiple levels during compatible disease interactions with Mycosphaerella graminicola显示文摘 | Rudd J J Keon J Hammond-Kosack K E | | 0，，： | 1 |
| 20 | Molecular mechanism of Nrf2 Activation by Oxidative Stress显示文摘 | Keon W K Seung J L Sang G K | 2005 | Antioxid Redox Signal2005，7，1112： | 1 |
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