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| 1 | Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis显示文摘AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,2016.Inclusion criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end points.Primary efficacyoutcome was 'brain death or Cerebral Performance Category(CPC) score of 5'.Secondary outcomes were 'CPC score 1,and 2-4','overall thrombotic events' and 'acute coronary stent thrombosis'.RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical trials.No significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was observed.CONCLUSION Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy. | Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Stress and fold localization in thin e lastic membranes 显示文摘 | Pocivavsek L Dellsy R Kern A Johnson S Lin B Lee KY C Cerda E | 2008 | Science2008，320，： | 1 |
| 3 | C erbB 2 expression in breast cancer detected by immunoblotting and immunohistochemistry 显示文摘 | Kerns B J M Pence J C Huper G etal | 1990 | Histochem Cytochem1990，38，： | 1 |
| 4 | Purification, eharaeterisationand erystallisation of photosystem Ⅱ from Thermosynechococcus elongatus cultivated in a new type of photobioreaetor显示文摘 | Kern J Loll B Luneberg C | 2005 | Biochimica et Biophysica Acta (BBA) - Bioenergetics2005，1706，： | 1 |
| 5 | Season and severity of prescribed burn in ponderosa pine forests:implications for understory native and exotic plants显示文摘 | Kerns B K Thies W G Niwa C G | 2006 | Ecoscience2006，13，1： | 1 |
| 6 | Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis显示文摘 | La E Kern J C Atarod E B | 2003 | Toxicol Lett2003，138，3： | 1 |
| 7 | Assessment of sediment contamination from pollutant discharge in surface waters显示文摘 | Kern U Li C C Westrich B | 1998 | Wat Sci Technol1998，37，67： | 1 |
| 8 | Perspectives on the etiology of chronic rhinosinusitis:an immune barrier hypothesis显示文摘 | KERN R C CONLEY D B WALSH W | 2008 | Am J Rhinol2008，22，： | 1 |
| 9 | Assessment of sediments contamination from poLLutant discharge in surface waters 显示文摘 | KERN U LI C C WESTRICH B | 1998 | Wat Sci Technical1998，37，67： | 1 |
| 10 | Assessment of Sediment Contamination from Pollutant Discharge in Surface Waters显示文摘 | Kern U Li C C Westrich B | 1998 | Water Science and Technology1998，37，67： | 1 |
| 11 | Pathology of the olfactory mucosa: implication for the treatment of olfactory dysfunction显示文摘 | KERN R C CONLEY D B HAINES G K 3rd | 2004 | Laryngoscope2004，114，： | 1 |
| 12 | An introduction to statistical energy analysis显示文摘 | Burroughs C B Fischer R W Kern F R | 1997 | Journal of the Acoustical Society of America1997，101，4： | 1 |
| 13 | Assessment of sediment contamination from pollution discharge in surface waters显示文摘 | KERN U LI C C WESTRICH B | 1998 | Water Science and Technology1998，37，67： | 1 |
| 14 | Perspectives on the etiology of chronic rhinosinusitis显示文摘 | TAN B K SCHLEIMER R P KERN R C | 2010 | Curr Opin Otolaryngol Head Neck Surg2010，18，： | 1 |
| 15 | Experiences with the subfrontal approach to manage extensive fractures of the frontal skull base 显示文摘 | SANDNER A KERN C B BLOCHING M B | 2006 | Laryngorhinootologie2006，85，4： | 1 |
| 16 | Isolation of a gene enco- ding a functional zinc finger protein homologous to erythroid Kruppel- like factor: identification of a new multigene family显示文摘 | Anderson K P Kern C B Crable S C | 1995 | Mol Cell Bi- ol1995，15，11： | 1 |
| 17 | Anintroduction to statistical energy analysis 显示文摘 | BURROUGHS C B FISCHER R W KERN F R | 1997 | Acoustical Society ofAmerica1997，101，4： | 1 |
| 18 | Exutero intrapartum treatment (EXIT),a resuscitation option for intra-thoracic foetal pathologies显示文摘 | Kern C Ange M Morales Peiry B Pfister RE | 2007 | Swiss Med Wkly2007，137，1920： | 1 |
| 19 | High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardic arrest in pigs: a prospective, randomized study显示文摘 | Berg R A Otto C W Kern K B | 1994 | Crit Care Med1994，22，2： | 1 |
| 20 | Season and severity of prescribed burn in ponderosa pine forests:implications for understory native and exotic plants显示文摘 | Kerns B K Thies W G Niwa C G | 2006 | Ecoscience2006，13，： | 1 |
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