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| 1 | Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions显示文摘·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with radiotherapy.Thirty-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions. | Lukas Reznicek Carmen Stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer Marcus Kernt | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 2 | Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy显示文摘AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic retinopathy.METHODS: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was included.Leak-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic location.Leaking was defined by late phase fluorescein angiograms compared to early phase.Retinal thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm circle.RESULTS: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,respectively.CONCLUSION: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution OCT.Therefore,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening. | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 3 | Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and P1GF显示文摘 | Kernt M Neubauer AS Liegl RG | 2010 | Br J Ophthalmol2010，94，： | 1 |
| 4 | 糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)显示文摘目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25~51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。 | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | 国际眼科杂志2011，11，7： | 1 |
| 5 | Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives 显示文摘 | Kernt M Kampik A | 2010 | Clin Ophthalmol2010，24，2： | 1 |
| 6 | In vitro safety of intravitreal moxifloxacin for endophthalmitis treatment显示文摘 | Kernt M Neubauer AS Ulbig MW | 2008 | J Cataract Refract Surg2008，34，3： | 1 |
| 7 | Health-economic aspects of glaucoam screening显示文摘 | Hirneiss C Niedermaier A Kernt M etal | 2010 | Ophthalmologe2010，107，2： | 1 |
| 8 | Alkylphosphoehnlines for in- traoeular lens eoatin显示文摘 | Eibl Kti Wertheimer C Kernt M | 2013 | J Cataract Refract Surg2013，39，3： | 1 |
| 9 | Focal and panretinal photocoagulation with a navigated laser (NAVILAS ) 显示文摘 | Kernt M Cheuteu R Vounotrypidis E | 2011 | Acta Ophthalmol2011，89，8： | 1 |
| 10 | Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP,survivin,and Bcl-2显示文摘 | Kernt M Neubauer AS Eibl KH | | 0，，： | 1 |
| 11 | Endophthalmitis:pathogenesis,clinical presentation,management,and perspectives显示文摘 | Kernt M Kampik A | 2010 | Clin Ophthalmol2010，4，： | 1 |
| 12 | Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP)显示文摘 | Kernt M Hirneiss C Neubauer AS | 2010 | Br J Ophthalmol2010，94，7： | 1 |
| 13 | Coenzyme Q10 pre- vents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX/Bcl- 2 ratio显示文摘 | Kernt M Hirneiss C Neubauer AS | 2010 | Acta Ophthalmologica2010，88，3： | 1 |
| 14 | Endophthalmitis: pathogenesis, clinical presentation, management, and perspectives显示文摘 | Kernt M Kampik A | 2010 | Clin Ophthal- mol2010，24，： | 1 |
| 15 | Cytoprotective effects of a blue light filtering intraocular lens on human retinal pigment epithelium by reducing photo toxic effects on vascular endothelia l growth factor alpha,Bax,and Bcl 2 expression显示文摘 | Kernt M Neubauer AS Lieg lR | | 0，，： | 1 |
| 16 | Indocyanine green increases light-induced oxidative stress, senescence, and matrix metalloproteinases 1 and 3 in human RPE cells显示文摘 | Kernt M Hirneiss C Wolf A | 2012 | Acta Ophthalmol2012，90，6： | 1 |
| 17 | Intracameral voriconazole: In vitro safety for human ocular cells显示文摘 | Kernt M Kampik A | 2009 | Toxicology2009，258，3： | 1 |
| 18 | Pars plana vitrectomy and internal limiting membrane peeling in epimacular membranes:correlation of function and morphology across the macula 显示文摘 | MAYER WJ VOGEL M NEUBAUER A KERNT M KAMPIK A WOLF A | 2013 | Ophthal- mologica2013，230，1： | 1 |
| 19 | Intracameral voriconazo le:In vitro safety for human ocular cells 显示文摘 | Kernt M Kampik A | 2009 | Toxicology2009，258，2： | 1 |
| 20 | Intravitreal bevacizumab (Avastin) treatment is safe in terms of intraocular and blood pressure 显示文摘 | KERNT M NEUBAUER A S KAMPIK A | 2007 | Acta Ophthalmol Scand2007，85，1： | 1 |
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