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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | 4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction Methods显示文摘The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a 'Process Archeology' in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models. | Manfred Breit Manfred Vogel Fritz Hubi Fabian Mrki Micheal Raps | 2008 | Tsinghua Science and Technology2008，13，S1： | 2 |
| 4 | Tellurite glass: A new candidate for fiber devices显示文摘 | WANG J S VOGEL E M SNIZER E | 1994 | Opt Mater1994，3，4： | 2 |
| 5 | How to STATE suitability and START transarterial chemoembolization in patients with intermediate stage hepatocellular carcinoma显示文摘 | Florian Hucke Matthias Pinter Ivo Graziadei Simona Bota Wolfgang Vogel Christian Müller Harald Heinzl Fredrik Waneck Michael Trauner Markus Peck-Radosavljevic Wolfgang Sieghart | 2014 | Journal of Hepatology2014，，： | 2 |
| 6 | Abiotic and Biotic Trans-formations of 1,1,1-Trichloroethane under MethanogenicConditions显示文摘 | VOGEL T M MCCARTY P L | 1987 | Environmental Science and Technology1987，21，12： | 1 |
| 7 | PFS clustering method显示文摘 | Vogel M A Wong A C | 1979 | IEEE PAMI1979，3，： | 1 |
| 8 | 10Be profiles in sea water显示文摘 | KUSAKABE M KU T L VOGEL J | 1982 | Nature1982，299，： | 1 |
| 9 | Expression pattern of intergrin adhesion molecules in endometriosis and endometrium显示文摘 | Ragidor PA Vogel C Regidodr M | 1998 | Hum Reprod Update1998，4，： | 1 |
| 10 | Creep beheavior of magnesium die- cast alloy ZA84显示文摘 | VOGEL M KRAFT O ARZT E | 2001 | Scripta Materialia2001，48，： | 1 |
| 11 | Implant-retained mandibular overdentures with Branemark System MKII implants:A prospective comparative study between delayed and immediate loading显示文摘 | Chiapasco M Abati S Romeo E Vogel G | | 0，，： | 1 |
| 12 | Real time simulation and online control for virtual test drives of cars 显示文摘 | Chucholowski C Vogel M von Stryk O | 1999 | High Perfo Sci and Eng Compu1999，8，： | 1 |
| 13 | Virtual Community Informatics: A Review and Research Agenda显示文摘 | Lee F S L Vogel D Limayem M | 2003 | Journal of Information Technology and Applica- tion2003，5，1： | 1 |
| 14 | Preclinical activity of taxotere (RP 56976, NSC 628503) against freshly explanted clonogenic human tumor cells: comparison with taxol and conventional antineoplastic agents 显示文摘 | Vogel M Hilsenbeck SG Depenbrock H | 1993 | Eur J Cancer1993，29，： | 1 |
| 15 | DNA repair eapacity: inennsisteney between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphoeytes 显示文摘 | VOGEL U DYBDAHL M FRENTZ G | 2000 | Mutat Res2000，461，3： | 1 |
| 16 | Tellurite glass: a new candidate for fiber devices 显示文摘 | WANG J S VOGEL E M SNITZER E | 1994 | Opt Mater1994，3，53： | 1 |
| 17 | Carbon distribution and aboveground net primary production in aspen,jack pine,and black spruce stands in Saskatchewan and Manitoba,Canada显示文摘 | Gower S T Vogel J G Norman J M | 1997 | J Geophys Res1997，102，29： | 1 |
| 18 | Vertical distraction osteogenesis of edentulous ridges for improvement of oral implant positioning : a clinical report of preliminary results 显示文摘 | Chiapasco M Romeo E Vogel G | 2001 | Int J Oral Maxillofac Implants2001，16，1： | 1 |
| 19 | Tongue protrusion and feeding dystonia: a hallmark of chorea-acanthocytosis显示文摘 | Bader B Walker R H Vogel M | 2010 | Mov Disord2010，25，1： | 1 |
| 20 | Oscillation-free operator splitting method for semilinear diffusion equations显示文摘 | Harwood R C Zhang L K Vogel G M | 2013 | Journal of Ap- plied Mathematics and Computation2013，18，7： | 1 |
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