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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | Core competence for sustainable competitive advantage 显示文摘 | Khalid H Zhang Y Malak N | 2002 | IEEE Transactions on Engineering Management2002，49，1： | 1 |
| 3 | Detection and relationships of cotton leaf curl virus and allied whitefly-transmitted geminiviruses occurring in Pakistan显示文摘 | Harrison B D Liu Y L Khalid S | 1997 | Annals of Applied Biology1997，130，1： | 1 |
| 4 | Large eddy simula- tion and preliminary modeling of the flow down- stream a variable geometry swirler for gas turbine combustors 显示文摘 | Yehia A Eldrainy Y Khalid M | 2011 | International Communications in Heat and Mass Transfer2011，38，8： | 1 |
| 5 | Phytoremediation of Saline Soils for Sustainable Agricultural Productivity显示文摘 | Ashraf Y M Shahzad M A Bs Khalid M | 2010 | Plant Adaptation and Phytoremediation2010，，： | 1 |
| 6 | Core competence for sustainable competitive advantage: a structured methodology for identifying core competence 显示文摘 | Khalid H Zhang Y Malak N | 2002 | IEEE Transactions on Engineering Management2002，49，1： | 1 |
| 7 | Bending behaviour of corrugated web beams显示文摘 | KHALID Y A CHAN C L SAHARI B B | 2004 | Journal of Materials Processing Technology2004，150，3： | 1 |
| 8 | Bending fatigue behavior of hybrid aluminum/composite drive shafts显示文摘 | Khalid Y A Mutasher S A Sahari B B | | 0，，01： | 1 |
| 9 | Finite Element Analysis of Corrugated Web Beams under Bending显示文摘 | Chan C L Khalid Y A Sahari B B | 2002 | Journal of Constructional Steel Research2002，58，13： | 1 |
| 10 | A Terahertz polarization insensitive dual band meta- material Absorber 显示文摘 | Ma Y Chen Q Grant J Saha S C Khalid A Cumming D R | 2011 | Optics Letters2011，36，6： | 1 |
| 11 | Finite element analysis of corrugated web beams under bending显示文摘 | CHAN C L KHALID Y A SAHARI B B | 2002 | Journal of Constructional Steel Research2002，58，11： | 1 |
| 12 | Bening behavior of corruged web beas显示文摘 | KHALID Y A CHAN C L SAHARI B B | 2004 | Journal of Processing Technology2004，150，3： | 1 |
| 13 | Bending Be- haviour of Corrugated Web Beams 显示文摘 | Khalid Y A Chan C L Sahari B B | 2004 | Journal of Mate- rials Processing Technology2004，150，3： | 1 |
| 14 | Design and fabrication of low cost filament winding machine显示文摘 | Abdalla F H Mutasher S A Khalid Y A | 2007 | Materials &Design2007，28，1： | 1 |
| 15 | Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha (2)-adreno-ceptor subtypes 显示文摘 | Khalid M llhami N Giudieelli Y | 2002 | J Pharmacol Exp Ther2002，300，1： | 1 |
| 16 | A novel synthesis procedure for ultra wideband (UWB) bandpass filters 显示文摘 | KHALID S WEN W P CHEONG L Y | 2013 | Progress In Electromagnetics Research2013，141，： | 1 |
| 17 | Bending behaviour of corrugated web beams显示文摘 | Khalid Y A Chan C L Sahari B B Hamouda AMS | 2004 | Journal of Materials Processing Technology2004，150，3： | 1 |
| 18 | Finite element analysis of corrugated web beams under bending显示文摘 | C L CHAN Y A KHALID B B SAHARI A M S HAMOUDA | 2002 | Journal of Constructional Steel Research2002，58，： | 1 |
| 19 | Bending behavior of corrugated web beams 显示文摘 | Khalid Y A Chan C L Sahari B B Hamouda A M S | 2004 | Journal of Materials Processing Technology2004，150，3： | 1 |
| 20 | Finite element analysis of corrugated web beams under bending 显示文摘 | Chan C L Khalid Y A Sahari B B Hamouda A M S | 2002 | Journal of Constructional Steel Research2002，58，11： | 1 |
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