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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The future of hip fractures in the United States:numbers,costs,and potential effects of postmenopausal estrogen显示文摘 | Cummings S R Rubin S M Black D | 1990 | Clinical Orthopaedics1990，252，： | 1 |
| 3 | A preprandial rise in plasma Ghrelin levels suggests a role in meal initiation in humans显示文摘 | Cummings D E Purnell J Q Frayo R S | 2001 | Diabetes2001，50，： | 1 |
| 4 | TYPE OF FALL AND RISK OF HIP AND WRIST FRACTURES-THE STUDY OF OSTEOPOROTIC FRACTURES显示文摘 | Nevitt M C Cummings S R Black D | 1993 | JOURNAL OF THE AMERICAN GERIATRICS SOCIETY1993，41，11： | 1 |
| 5 | Gastrointestinal surgery as a treatment for diabetes显示文摘 | Cummings D E Flum D R | 2008 | JAMA2008，299，： | 1 |
| 6 | A harmonic method for predicting shallow-water tides显示文摘 | ZETLER B D CUMMINGS R A | 1967 | J Mar Res1967，25，1： | 1 |
| 7 | Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial显示文摘 | Wardlaw D Cummings S R Van Meirhaeghe J | 2009 | Lancet2009，373，9668： | 1 |
| 8 | Clinical use of bone densitometry:scientific review显示文摘 | Cummings S R Bates D Black D M | 2002 | JAMA2002，288，： | 1 |
| 9 | Fabrication of 3 nm wires using 100 keV electron beam lithography and poly(methyl methacrylate)resit显示文摘 | Thoms S Beaumont S P | 1996 | Appl Phys Lett1996，68，： | 1 |
| 10 | Increased pulmonary vascular filtration pressure does not alter lung liquid secretion in fetal sheep显示文摘 | CARLTON D P CUMMINGS J J POULAIN F R | 1992 | Appl Physiol1992，72，： | 1 |
| 11 | Focus of attention at work:constrnct definition and empirical validation 显示文摘 | GARDNER D G DUNHAM R B CUMMINGS L L | 1989 | Journal of Occupational and Organizational Psychology1989，，62： | 1 |
| 12 | A preprandial rise in plasma Ghrelin levels suggests a role in meal initiation in humans 显示文摘 | Cummings D E Purnell J Q Frayo R S | 2001 | Diabetes2001，50，8： | 1 |
| 13 | Once-yearly zoledronic acid for treatment of post-menopausal osteoporosis显示文摘 | Black DM Delmas PD Eastell R Reid IR Boonen S Cauley JA Cosman F Lakatos P Leung PC Man Z Mautalen C Mesenbrink P Hu H Caminis J Tong K Rosario-Jansen T Krasnow J Hue TF Sellmeyer D Eriksen EF Cummings SR HORIZON Pivotal Fracture Trial | | 0，，： | 1 |
| 14 | A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc:alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase显示文摘 | Cummings R D Trowbridge I S Kornfeld S | 1982 | J Biol Chem1982，257，13： | 1 |
| 15 | Bonedensity at various sites for prediction of hip frac-tures显示文摘 | Cummings S R Black D M Nevitt M C | 1993 | Lancet1993，341，8837： | 1 |
| 16 | Dynamics of aboveground and soil carbon and nitrogen stocks and cycling of available nitrogen along a land-use gradient in Rond(o)nia,Brazil显示文摘 | HUGHES R F KAUFFMAN J B CUMMINGS D L | 2002 | Ecosystems2002，5，3： | 1 |
| 17 | Lung overexpansion increases pulmonary microvascular protein permeability in young lambs显示文摘 | Carkon D P Cummings J J Scheerer R G | 1990 | J Appl Physiol1990，69，2： | 1 |
| 18 | Aerody-namic analysis of a generic fighter using delayed de- tached-eddy simulation 显示文摘 | Jeans T McDaniel D Cummings R | 2009 | Journal of Aircraft2009，46，4： | 1 |
| 19 | Photo-induced environmental depletion processes of beta-blockers in river waters显示文摘 | LIU Q T CUMMING R I SHARPE A D | 2009 | Photochemical&Photobiological Sciences2009，8，6： | 1 |
| 20 | Characterization of a water peening process 显示文摘 | Daniewicz S R Cummings S D | 1999 | Journal of Engineering Materials and Technology Transactions of the ASME1999，121，3： | 1 |
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