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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Renal stone disease and obesity: what is important for urologists and nephrologists 显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Failure2012，34，10： | 1 |
| 3 | The use of cervical length and change in cervical length for prediction of spontaneous preterm birth in asymptomatic twin pregnancies显示文摘 | Khalil MI Alzahrani MH Ullah A | 2013 | Eur J Obstet Gynecol Reprod Biol2013，169，2： | 1 |
| 4 | Renal stone disease and obesity:what is important for urologists and nephrologists?显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Failure2012，34，10： | 1 |
| 5 | The use of cervical length and change in cervical length for prediction of spontaneous pre- term birth in asymptomatic twin pregnancies 显示文摘 | Khalil MI Alzahrani MH Ullah A | 2013 | Eur J Obstet Gynecol Reprod Biol2013，169，： | 1 |
| 6 | Renal Stone Disease and Obesity: What is Important for Urologists and Nephrologists? 显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Failure2012，34，10： | 1 |
| 7 | Phacotrabeculectomy versus two-stage operation:a matched study显示文摘 | El-Sayyad FF Helal MH Khalil MM | 1999 | Ophthalmic Surg Lasers1999，30，4： | 1 |
| 8 | Phaeotrabeculec- tomy versus two-stage operation:a matched study 显示文摘 | EI-Sayyad FF Helal MH Khalil MM | | Ophthalmic Surgery and Lasers0，30，4： | 1 |
| 9 | Renal stone disease and obesi- ty: what is important for urologists and nephrologists 显示文摘 | Ahmed MH Ahmed HT Khalil AA | 2012 | Renal Fail- ure2012，34，10： | 1 |
| 10 | Obesity - related glomerulopathy: anther nail in the coffin of the the epidemic of end -stage renal disease 显示文摘 | Ahmed MH Khalil AA | 2007 | J Clin Pathol2007，60，5： | 1 |
| 11 | Phacotrabeculectomy versus two-stage operation:a matched study显示文摘 | El-Sayyad FF Helal MH Khalil MM El-Maghraby MA | | 0，，04： | 1 |
| 12 | Obesity-related glomerulopathy:another nail in the coffin of the epidemic of end-stage renal disease显示文摘 | AHMED MH KHALIL AA | 2007 | J Clin Pathol2007，60，5： | 1 |
| 13 | Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers 显示文摘 | Pope LE Khalil MH Berg JE | 2004 | J Clin Pharmacol2004，44，10： | 1 |
| 14 | Phacotrabeculectomy versus two stage operation:a match study显示文摘 | EI-sayad FF Heldl MH Khalil MM | 1999 | Ophthmic Surg Lasers1999，30，4： | 1 |
| 15 | Synthesis,characterization,m(o)ssbauer parameters,and antitumor activity of Fe (Ⅲ) curcumin complex显示文摘 | Khalil MI Al-Zahem AM Al-Qunaibit MH | | 0，，： | 1 |
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