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12篇 您的检索式：作者名="Khan UI"

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		题名	作者	年代	出处	被引量
	1	Independent and Syner- gistic Associations of Asthma and Obesity with Systemic Inflam- mation in Adolescents显示文摘	Khan UI Rastogi D Isasi CR	2012	J Asthma2012，49，10：	1
	2	Progression from metabolically benign to at-risk obesity in perimenopausal women: a longitudinal analysis of study of women across the nation ( SWAN ) 显示文摘	Khan UI Wang D Karvonen-Gutierrez CA	2014	J Clin Endocrinol Metab2014，99，7：	1
	3	Independent and synergistic associations of asthma and obesity with systemic inflammation in adolescents显示文摘	Khan UI Rastogi D Isasi CR		0，，：	1
	4	Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: Cross-sectional analyses from the KEEPS Study显示文摘	Huang G Wang D Khan UI	2012	CardiovascDiabetol2012，11，：	1
	5	Bernard-Soulier syndrome: a challenge for anesthetist in an emergency surgery显示文摘	UI Haq MI Sohaib M Khan S	2015	J Anaesthesiol Clin Pharmacol2015，31，3：	1
	6	Progression from metabolically benign to at-risk obesity in perimenopausal women:a longitudinal analysis of study of women across the nation(SWAN)显示文摘	Khan UI Wang D Karvonen-Gutierrez CA	2014	J Clin Endocrinol Metab2014，99，7：	1
	7	Associations between retinol- binding protein 4 and cardiometabolic risk factors and subclinical ath- erosclerosis in recently postmenopausal women: cross-sectional analy- ses from the KEEPS study 显示文摘	Huang G Wang D Khan UI	2012	Cardiovasc Diabetol2012，11，：	1
	8	Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: Cross- sectional analyses from the KEEPS Study显示文摘	Huang G Wang D Khan UI	2012	Cardiovase Diabetol2012，11，1：	1
	9	Burden of subclinical cardiovascular disease in ' metabolically benign' and ' at-risk' overweight and obese women: the Study of Women's Health Across the Nation (SWAN) 显示文摘	Khan UI Wang D Thurston RC	2011	Atherosclerosis2011，217，1：	1
	10	Independent and syner gistic associations of asthma and obesity with systemic in- flammation in adolescents 显示文摘	Khan UI Rastogi D Isasi CR	2012	J Asthma2012，49，10：	1
	11	The adipokine pro- file ofmetabolically benign obese and at- risk normal weight postmenopausal women: the Women's Health Initiative Obser- vational Study 显示文摘	Khan UI Ogorodnikova AD Xu L	2014	Obesity (Silver Spring)2014，22，3：	1
	12	Effect of Marsdenia tenacissima extract on G2/M cell cycle arrest by upregulating 14-3-3σ and downregulating c-myc in vitro and in vivo显示文摘Objective: Marsdenia tenacissima extract(MTE) is a traditional Chinese herbal medicine with anti-cancer activity. In some previous studies, different mechanism actions of the anti-cancer effect of MTE have been revealed. In this study, we first observed that MTE exhibited G2/M cell cycle arrest on two different human breast cancer cell lines, MDA-MB-231 and MCF-7 by mediating 14-3-3σ and c-myc.Methods: The effect of MTE on G2/M cell cycle arrest was evaluated in MDA-MB-231 and MCF-7 cell lines. MTT assay was done for evaluation of cell viability. Flow cytometry was employed for cell cycle analysis. Western blotting analysis and immunohistochemistry were performed to analyze the expression of G2/M cell cycle-related key protein in cells and tissue samples. Animal studies have been conducted to elucidate the anti-tumor effect of MTE.Results: Cell cycle is the backbone for developing cancer. Cell cycle proteins play a major role in the progression of cell cycle and cell proliferation. However, some key protein directly or indirectly modulate the action of cell cycle protein that highly affect cell cycle regulation. In order to investigate cellular proliferation of cancer, we observed that MTE induced the upregulation of 14-3-3σ and downregulation of c-myc,and then reduced the expression of G2/M cell cycle associated key protein, leading to the inhibition of cellular entry into mitosis phase. We also confirmed that MTE exerted a significant antitumor effect on the MDA-MB-231 xenograft model in vivo.Conclusion: G2/M cell cycle arrest occurred by the action of MTE, mediated by the upregulation of 14-3-3σ as well as downregulation of c-myc in MDA-MB-231 and MCF-7 cell lines.	Li Sun Qurat UI Ain Ying-sheng Gao Ghulam Jilany Khan Sheng-tao Yuan Debmalya Roy	2019	Chinese Herbal Medicines2019，11，2：	1

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