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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Topological designfor vibrating structures显示文摘 | Ma Z D Kikuchi N Cheng H C | 1995 | Computer Methods inApplied Mechanics and Engineering1995，121，： | 1 |
| 3 | Topological design for vibration structures显示文摘 | Ma Z D Kikuchi N Hsien C C | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，： | 1 |
| 4 | hnaging of uhraweak spon- taneous photon emission from human body displaying diurnal rhythm 显示文摘 | Kobayashi M Kikuchi D Okanmra H | 2009 | PLoS one2009，4，7： | 1 |
| 5 | Closed loop direct metal deposition: art to part 显示文摘 | Mazumder J Dutta D Kikuchi N | 2000 | Optics and Lasers in Engineering2000，34，： | 1 |
| 6 | Closed loop direct metal deposition: art to part显示文摘 | Mazumder J Dutta D Kikuchi N | 2000 | Optics and Lasers in Engineering2000，34，46： | 1 |
| 7 | Outcome of children with refractory anaemia with excess of blast(RAEB) and RAEB in transformation (RAEB-T) in the Japanese MDS99 study显示文摘 | Kikuchi A Hasegawa D Ohtsuka Y | | 0，，05： | 1 |
| 8 | Callus induction and micropropagation improved by colchicine and phytoregulators in Kappaphycus alvarezii( Rhodophyta, Solieriaceae ) 显示文摘 | Hayashi L Yokoya N S Kikuchi D M | 2008 | J Appl Phycol2008，20，： | 1 |
| 9 | Closed loop direct metal deposition art to part 显示文摘 | Mazumder J Dutta D Kikuchi N | 2000 | Optics and Lasers in Engineering2000，，34： | 1 |
| 10 | Closed loop direct metal deposition: art to part 显示文摘 | MAZUMDER J DUTTA D KIKUCHI N | 2000 | Optics and Lasers in Engineering2000，34，： | 1 |
| 11 | Genet distribution of sporocarps and ectomycorrhizas of Suillus pictus in a Japanese white pine plantation 显示文摘 | Hirose D Kikuchi J Kanzaki N | 2004 | New Phytologist2004，164，3： | 1 |
| 12 | Topological design for vibrating structures 显示文摘 | Ma Z D Kikuchi N Cheng H C | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，14： | 1 |
| 13 | An alternative method for the selective bromination of alkylbenzenes using NaBrO3/NaHSO3 reagent显示文摘 | Kikuchi D Sakaguchi S Ishii Y | 1998 | The Journal of Organic Chemistry1998，63，17： | 1 |
| 14 | Benefits of endoscopic submucosal dissection according to size and location of gastric neoplasm,compared with conventional mucosal resection显示文摘 | Hoteya S Lizuka T Kikuchi D | 2009 | J Gastroenteral Hepatol2009，24，6： | 1 |
| 15 | Selective molecular potassium channel blockade prevents atrial fibrillation显示文摘 | Guy A Kikuchi A Ian D | 2010 | Circulation2010，121，21： | 1 |
| 16 | 2S globulins of soybean seeds 2 physicochemical and biological properties of protease inhibitors in 2S globulins 显示文摘 | Koshiyama Y Kikuchi M Fukushima D | 1981 | Journal of Agricultural and Food Chemistry1981，29，： | 1 |
| 17 | Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers 显示文摘 | Kikuchi N Min SK Ueda D | 2012 | J Strength CondRes2012，26，12： | 1 |
| 18 | Topology and shape optimization technique for structural dynamic problems 显示文摘 | Ma Z D Cheng H C Kikuchi N | 1992 | Journal of Recent Advances in Structural Problems1992，248，10： | 1 |
| 19 | Topological design for vibrating structures显示文摘 | MA Z D KIKUCHI N CHENG H C | 1995 | Computational Methods in Applied Mechanics and Engineering1995，121，： | 1 |
| 20 | Topological design for vibrating structures 显示文摘 | Ma Z D Kikuchi N Cheng H C | 1995 | Computer Methods in Applied Mechanics and Engineering1995，121，4： | 1 |
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