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| 1 | Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation显示文摘Background Endothelial function,as measured by big endothelin-1(ET-1),has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease.Nevertheless,there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation(AF).We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF.Methods The study population consisted of 238 consecutive AF patients(67.6%with paroxysmal AF and 32.4%with persistent AF).The patients were divided into two groups(high-or low-intermediate risk group)based on CHADS2 and CHA2 DS2-VASc scores(score≥2 or<2,respectively).Clinical,laboratory,and echocardiographic parameters were evaluated,and the CHADS2/CHA2DS2-VASc scores were compared between groups.The association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was assessed.Multivariate logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc scores.Results The high CHADS2/CHA2DS2-VASc score group had older age,higher big ET-1 levels,and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group(P<0.05).Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS2/CHA2DS2-VASc scores[odds ratio(OR)=2.545 and OR=3.816;both P<0.05].Conclusions Our study indicates that in non-valvular AF,big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc scores.Big ET-1 may serve as a useful marker for risk stratification in this setting. | Li-Hui ZHENG Shang-Yu LIU Feng HU Er-Peng LIANG Ling-Min WU Hong-Lei WANG Ammar M Killu Yan YAO | 2019 | Journal of Geriatric Cardiology2019，16，11： | 2 |
| 2 | A photochemical kinetics mechanism for urban and regional scale computer modeling显示文摘 | GERY M W WHITTEN G Z KILLUS J P | 1989 | Journal of Physical Research1989，94，12： | 1 |
| 3 | A photochemical kinetics mechanism for urban and regional scale computer modeling 显示文摘 | Gery M W Whitten G Z Killus J P | 1989 | Journal of Geophysical Research: Atmospheres1989，94，12： | 1 |
| 4 | A Photochemical Kinetics Mechanism for Urban and Regional Scale Computer Modeling显示文摘 | GERY M W WHITTEN G Z KILLUS J P | 1989 | Journal of Geophysical Research: Atmospheres (1984 2012)1989，94，12： | 1 |
| 5 | A photochemical kinetics mechanism for urban and regional scale computer modeling显示文摘 | Gery M W G Z Whitten J P Killus | 1989 | J Geophys Res1989，94，： | 1 |
| 6 | A photochemical kinetics mechanism for urban and regional scale computer model- ing显示文摘 | GERY M W WHITTEN G Z KILLUS J P | 1989 | Journal of Geophysical Research : Atmospheres ( 1984 - 2012)1989，94，12： | 1 |
| 7 | Outcomes of cardiac resynchronization thera-py in the elderly显示文摘 | Ammar M Killu M | 2013 | PACE2013，36，6： | 1 |
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