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| 1 | Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis显示文摘AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients. | Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu Yong-Li Wang Jie You Qin Ning | 2018 | World Journal of Gastroenterology2018，24，21： | 25 |
| 2 | Superinfective Hepatitis E Virus Infection Aggravates Hepatocytes Injury in Chronic Hepatitis B显示文摘Hepatitis E virus(HEV)infection is a major cause of morbidity in endemic areas.Its consequences among chronic hepatitis B(CHB)patients have been under-reported.The aim of this study was to assess the impact of superinfective HEV infection(acute and past)on virological and clinical features of patients with CHB infection.Clinical,biochemical,virological and immunological data of 153 CHB patients including 98 with hepatitis B virus(HBV)monoinfection and 55 with HBV-HEV superinfection with both HEV and HBV infection was retrospectively investigated and analyzed in this study conducted in Wuhan,China.An overall anti-HEV IgG seroprevalence was found to be 35.9% in CHB patients.HBV-HEV superinfection patients showed significantly higher rate of complications(ascites,hepato-renal syndrome&encephalopathy)(all with P=0.04),cirrhosis(P<0.001)and acute-on-chronic liver failure(P<0.001)than HBV monoinfection patients.They also displayed elevated ALTs(P<0.001)and total serum bilirubin(P<0.001)with diminished albumin(P<0.001)and HBV viral load(P<0.001).Cytokines assay revealed increased expression of IL-6(P=0.02),IL-10(P=0.009)and TNF-α(P=0.003)in HBVHEV superinfection patients compared to HBV monoinfection patients.Our study demonstrated that HEV superinfection in CHB patients was associated with progressive clinical manifestation,which is likely due to the enhanced expression of cytokines related with hepatocytes necrosis.HEV was also associated with repressed HBV replication,but the underlying mechanism requires further investigation. | Semvua Bukheti Kilonzo Yong-Ii WANG Qun-qun JIANG Wen-yu WU Peng WANG Qin NING Mei-fang HAN | 2019 | Current Medical Science2019，39，5： | 5 |
| 3 | Seasonal dynamics of rodent fleas and its implication on control strategies in Lushoto district, north-eastern Tanzania显示文摘 | Makundi RH Kilonzo BS | 1994 | J Appl Entomol1994，118，1： | 1 |
| 4 | Association of reduction of AFB1-induced liver turnouts by antioxidants with increased activity of microsomal enzymes 显示文摘 | Nyandieka HS Wakhis J Kilonzo MM | 1990 | Indian Journal of Medical Research1990，92，3： | 1 |
| 5 | Hydrochemistry and source of high fluoride in groundwater of the Nairobi area, Kenya显示文摘 | Marleen Coetsiers Fidelis Kilonzo Kristine Walrevens | 2008 | Hydrological Sciences Journal2008，53，6： | 1 |
| 6 | Systematic review of the clinical effectiveness and cost-effectiveness of photodynam- ic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer 显示文摘 | MOWATT G ZHU S KILONZO M | 2010 | Health Technol Assess2010，14，4： | 1 |
| 7 | Prevalence of urinary tract infection among pregnant women at Bugando Medical Centre, Mwanza, Tanzania 显示文摘 | Masinde A Gumodoka B Kilonzo A | 2009 | Tanzan J Health Res2009，11，3： | 1 |
| 8 | The effects of non-Newtonian fermentation broth viscosity and small bubble segregation on oxygen mass transfer in gas-lift bioreactors:A critical review显示文摘 | Kilonzo P M Margaritis A | 2004 | Biochemical Engineering Journal2004，17，1： | 1 |
| 9 | Cost effective-ness of tension-free vaginal tape for the surgical man-agement of female stress incontinence显示文摘 | Kilonzo M Vale L Stearns S C | 2004 | Int J TechnolAssess Health Care2004，20，： | 1 |
| 10 | Outcome of acute peritoneal dialysis in northern Tanzania显示文摘 | Kilonzo KG Ghosh S Temu SA | | 0，，： | 1 |
| 11 | Secondary prevention and learning needs post percutaneous coronary intervention (PCI) : Perspectives of both patients and nurses显示文摘 | Kilonzo B O Connell R | 2011 | Journal of Clinical Nursing2011，20，78： | 1 |
| 12 | Comparison of an adjustable anchored single-incision mini-sling, AjustTM, with a standard mid-urethral sling, TVT-OTM : a health econom- icevaluation显示文摘 | BOYERS D KILONZO M MOSTAFA A | 2013 | BJUlnt2013，112，8： | 1 |
| 13 | Biotransformation of 3-nitro-4-hydroxybenzene arsenic acid (roxarsone) and release of inorganic arsenic by Clostridium species显示文摘 | Stolz J F Perera E Kilonzo B etal | 2007 | Environmental science and technology2007，41，3： | 1 |
| 14 | Using gender analysis to- build voluntary counselling and testing responses in Kenya显示文摘 | Taegtmeyer M Kilonzo N Mung' ala L | 2006 | Trans R Soc Trap Med Hyg2006，100，： | 1 |
| 15 | Outcome of acute peritoneal dialysis in northern Tanzania显示文摘 | Kilonzo K Ghosh S Temu S | 2012 | Perit Di- al Int2012，32，： | 1 |
| 16 | Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosisand urine biomarkers (FISH, ImmunoCyt, NMP22) and cytol- ogy for the detection and follow up of bladder cancer显示文摘 | Mowatt G Zhu S Kilonzo M | 2010 | Health Technol Assess2010，14，4： | 1 |
| 17 | Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH,ImmunoCyt,NMP22) and cytology for the detection and follow-up of bladder cancer显示文摘 | Mowatt G Zhu S Kilonzo M | 2010 | Health Technol Assess2010，14，4： | 1 |
| 18 | Pattern, knowledge and practices of HbA1C testing among diabetic patients in a Kenyan tertiary referral hospital 显示文摘 | Matheka D M Kilonzo J M Munguti C M | 2013 | Global Health2013，5，9： | 1 |
| 19 | Association of reduction of AFB1-induced liver tumours by antioxidants with increased activity of microsomal enzymes显示文摘 | Nyandieka H S Wakhis J Kilonzo M M | 1990 | Indian Journal of Medicine Research1990，92，： | 1 |
| 20 | Using gender analysis tobuild voluntary counselling and testing responses in Kenya显示文摘 | Taegtmeyer M Kilonzo N Mung'ala L | 2006 | Trans R Soc Trop Med Hyg2006，100，： | 1 |
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