|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 3 | Role of Small Bowel Follow-through in Diagnosing Inflammation of the Terminal Ileum in Pediatric Patients显示文摘 | Matthew Stenerson Eric Vittinghoff Melvin B Heyman Grace E Kim Neera Gupta | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，4： | 2 |
| 4 | Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer显示文摘 | Kim J H Choi E K Kim S B | 2001 | Int J Radiat Oncol Biol Phys2001，50，1： | 2 |
| 5 | Electricity generation from swine wastewater using microbialfuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Res2005，39，20： | 1 |
| 6 | Periodic mesoporous organosilicas with multiple bridging groups and spherical morphology显示文摘 | CHO E B KIM D JARONIEC M | 2007 | Langmuir2007，23，11： | 1 |
| 7 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | MIN B KIM J R OH S E | 2005 | Water Research2005，39，20： | 1 |
| 8 | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants显示文摘 | Dowling W E Kim B Mason C J | 2002 | AIDS2002，16，： | 1 |
| 9 | Overexpress cyclooxygenase2 is associated with a poor prognosis in patients with squamous cell carcinoma of the treated with radiation and concurrent chemotherapy显示文摘 | Kim Y B Kim G E Cho N H | 2002 | Cancer2002，95，： | 1 |
| 10 | Ventricular diverticula on cardiac CT: more common than previously thought显示文摘 | SRICHAI M B HECHT E M KIM D C | 2007 | Am J Roentgenol2007，189，2： | 1 |
| 11 | 查看详情显示文摘 | (e) Kim D C Lee Y R Yang B -S Shin K J Kim D J Chung B Y Yoo K H | | 0，，： | 1 |
| 12 | Two-dimensional photonic crystal color filter development显示文摘 | E H Cho H S Kim B H Cheong | | 0，，10： | 1 |
| 13 | Immunogenicity of an adenoviral- based middle east respiratory syndrome coronavirus vaccine in balb/c mice显示文摘 | Kim E Okada K Kenniston T Raj V S A1Hajri M M Farag E A AIHairi F Osterhaus A D Haagmans B L Gambotto A | 2014 | Vaccine2014，32，45： | 1 |
| 14 | Electricity generation from swine wastewater using microbial fuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Research2005，39，20： | 1 |
| 15 | Photochemical Destruction of Cyanide in Landfdl Leachate 显示文摘 | Kim B R Podsiadlik D H Kalis E M | 1998 | Journal of Environmental Engineering1998，，11： | 1 |
| 16 | Preparation and properties of waterborne poly( urethane urea) s for adhesives : the effects of the 2, 2-bis(hydroxylmethyl) propionic acid content on the properties显示文摘 | Kwak Y S Kim E Y Yoo B H | 2004 | Journal of Applied Polymer Science2004，94，： | 1 |
| 17 | Dynamic channel reservation based on mobility in wireless ATM networks显示文摘 | KIM Y C LEE D E KIM Y S MUKHERJEE B | 1999 | IEEECommunication Magazine1999，37，1： | 1 |
| 18 | Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation 显示文摘 | OH E J KANG S W KIM B S | 2008 | Biomed Mater Res2008，86，3： | 1 |
| 19 | Overexpression of a Brassicarapa NGATH A gene in Arabidopsis thaliana negatively affectscell proliferation during lateral organ and root growth 显示文摘 | Kwon S H Lee B H Kim E Y | 2009 | PlantCell Physiol2009，50，12： | 1 |
| 20 | Biological hydrogen production measured in batch anaerobic respirometers显示文摘 | Logan B E Oh S E Kim I S | 2002 | Environmental Science and Technology2002，36，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员