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| 1 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 2 | Logical modeling:a tool for management science显示文摘 | Lee R M | 1988 | Decision Support Systems1988，1，： | 1 |
| 3 | Calmodulin kinase isfounctionally targeted to the action potential plateau for regulation of L-type Ca^2+ current in rabbit cardiomyocytes显示文摘 | WU Y KIMBROUGH III J T COLBRAN K J | 2004 | J Physiol2004，554，1： | 1 |
| 4 | Mortality among capacitor workers exposed to polychlorinated biphenyls (PCBs),a long-term update显示文摘 | KIMBROUGH R D KROUSKAS C A XU W | 2014 | International Archives of Occupational and Environmental Health2014，，： | 1 |
| 5 | Tricholoma titans, a new species from Florida 显示文摘 | BIGELOW H E KIMBROUGH J W | 1998 | Mycotaxom1998，11，： | 1 |
| 6 | Stunted growth,increased mortality,and liver tumors in offspring of polybrominated biphenyl (PBB) dosed Sherman rats显示文摘 | Groce DF Kimbrough RD | 1984 | J Toxicol Environ Health1984，14，56： | 1 |
| 7 | The Coast Guard's KSS Project 显示文摘 | Kimbrough S O Pritchett C W | 1995 | Interface1995，20，6： | 1 |
| 8 | Computers Play the Beer Game:Can Artificial Agents Manage Supply Chains显示文摘 | WU D J ZHONG F | 2002 | Decision Support Systems2002，33，3： | 1 |
| 9 | Pseudallescheria boydii keratitis显示文摘 | Bradley J C Hirsch B A Kimbrough R C | 2006 | Scand J Infect Dis2006，38，1112： | 1 |
| 10 | A Critical Assessment of Chromium in the Environment显示文摘 | Kimbrough D E Cohen Y Winer A M | 1999 | Critical Reviews in Environmental Science and Technology1999，29，1： | 1 |
| 11 | Growth hormone attenuates the abnormal distribution of body water in critically ill surgical patients显示文摘 | Gatzen C Scheltinga MR Kimbrough TD | 1992 | Surgery1992，112，2： | 1 |
| 12 | Computers play the beer game: can artificial Agents manage supply chains? 显示文摘 | KIMBROUGH S O WU D J ZHONG F | 2002 | Decision Support Systems2002，33，3： | 1 |
| 13 | Optimal control of Electro-magnetic Brake Retarders显示文摘 | SCOTT Kimbrough | | SAE0，，： | 1 |
| 14 | Health implications of 2,3,7,8-tetrachlorodibenzodioxin (TCDD) contamina- tion of residential soil显示文摘 | RD Kimbrough H Falk P Stehr | 1984 | J Toxicol Environ Health1984，，14： | 1 |
| 15 | Electrochemical process for the removal of bromide from California State project water显示文摘 | Kimbrough D E Suffet I H | 2006 | Journal of Water Supply:Research and Technology-AQUA2006，55，3： | 1 |
| 16 | Treatment ofmeuromyelitis optica: review and recommendations显示文摘 | Kimbrough DJ Fujihara K Jacob A | 2012 | MultScler Relat Disord2012，1，4： | 1 |
| 17 | Structural characterization of the molecular platform for type Ⅲ secre- tion system assembly显示文摘 | Yip C K Kimbrough T G Felise H B | 2005 | Nature2005，435，7042： | 1 |
| 18 | A critical assessment of chromium in the environment显示文摘 | Kimbrough D E Cohen Y Winer A M | 1999 | Critical Reviews in Environmental Science and Technology1999，29，： | 1 |
| 19 | The effect of conference calls on analyst and market underreaction to earnings announcements 显示文摘 | Kimbrough M | 2005 | The Accounting Review2005，80，： | 1 |
| 20 | Topicai tretinoin therapy for hyperpigmented lesions caused by inflammation of the skin in black patients显示文摘 | Bulengo-Ransby SM Griffiths CE Kimbrough Green CK | 1993 | N Engl J Med1993，328，20： | 1 |
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