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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | 获得性穿通性皮肤病:22例患者临床病理学特征研究 | Saray Y. Sekin D. Bileziki B. 任建文 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，10： | 2 |
| 3 | Synthesis of Triazine-Based Polyimide Nanocomposites with Flower-Like ZnO by Microwave-Assisted Solvothermal Technique显示文摘 | Turgay Se?kin Nilufer K?v?lc?m Süleyman K?ytepe | 2013 | Polymer-Plastics Technology and Engineering2013，，13： | 1 |
| 4 | Porous pyridine based polyimide–silica nanocomposites with low dielectric constant显示文摘 | Nilufer K?v?lc?m Turgay Se?kin Süleyman K?ytepe | 2013 | Journal of Porous Materials2013，，4： | 1 |
| 5 | Microsurgical anatomy of the posterior spinal artery via a far-lateral transcondylar approach显示文摘 | Se(c)kin H Ates O Bauer AM | 2009 | J Neurosurg Spine2009，10，3： | 1 |
| 6 | Chronic subdural hematoma in patients with idiopathic thrombocytopenic purpura: a case report and review of the literature显示文摘 | Se kin H Kazanci A | 2006 | Surgical Neurology2006，66，： | 1 |
| 7 | The role of human herpesvirus-6,Epstein-Barr virus and cytomegalovirus infections in the etiopathogenesis of different types of cutaneous drug reactions显示文摘 | Ozcan D Se kin D Bilezik i B | 2010 | Int J Dermatol2010，49，11： | 1 |
| 8 | Hydroxyehloroquine ototoxieity in a patient with rheumatoid arthritis 显示文摘 | Se~kin U Ozoran K Ikinciogullari A | 2000 | Rheumatol Int2000，19，5： | 1 |
| 9 | Diffuse and focal adenomyosis: MR imaging findings显示文摘 | Byun JY Kin SE Choi BG | 1999 | radiographics1999，19，1： | 1 |
| 10 | Deep dermatophytosis caused by Trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient显示文摘 | Sekin D Arikan S Haberal M | 2004 | J Am Acad Dermatol2004，51，5： | 1 |
| 11 | Synthesis of silica --supported rhodium carbine complex as efficient catalyst for the addition of phenylboronic acid to aldehydes显示文摘 | Ozdemir I Gurbuz N Se? kin T ? etinkaya B | 2005 | Applied Organo- metallic Chemistry2005，19，5： | 1 |
| 12 | specific association of human telomerase activity with immortal cells and cancer显示文摘 | Kin NW Piatyszek MA Prow se KK | 1994 | Science1994，266，： | 1 |
| 13 | Treatment of uremic pruritus with narrow band ultraviolet B phototherapy:an open pilot study显示文摘 | Ada S Se(c)kin D Budako(g)lu I | | 0，，： | 1 |
| 14 | Polymerization and characterization of acrylonitrile withγ-methacryloxypropyltrimethoxy-silane graftedbentonite clay显示文摘 | Se kin T Gültek A i duygu M G nal Y | 2002 | Journal of Applied Polymer Science2002，84，1： | 1 |
| 15 | Second-trimester genetic amniocentesis:5-year experience显示文摘 | Turhan N Eren Sekin NC | 2005 | Arch Gynecol Obstet2005，271，1： | 1 |
| 16 | Oxidative stress status in patients with acute urticaria显示文摘 | Kalkan G Sekin HY Duygu F | 2014 | Cutan Ocul Toxicol2014，33，2： | 1 |
| 17 | Diffuse and focal adenomyosis: MR imaging findings显示文摘 | Byun JY Kin SE Choi BG | 1999 | Radiographics1999，19，1： | 1 |
| 18 | Diffuse and focal adenomyosis; MR imaging findings显示文摘 | Byun JY Kin SE Choi BG | 1999 | Radiographics1999，19，1： | 1 |
| 19 | A useful alternative approach for the treatment of well-demarcated Basal cell carcinoma:surgical excision and margin control with tzanck smear test显示文摘 | BABA M DURDU M SEKIN D | 2010 | Dermatol Surg2010，36，5： | 1 |
| 20 | Diffuse and focal adenomyosis:MR imaging findings显示文摘 | Byun JY Kin SE Choi BG | 1999 | Radiographics1999，19，1： | 1 |
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