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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 高性能发动机活塞销衬套材料的研制显示文摘近年来,柴油机要求更高的性能和更长的寿命。由于气缸爆发压力高,活塞销衬套的工作负荷和温度变得更高。因此要求活塞销衬套具有高承载能力、耐磨性和耐腐蚀性。为了改善铜衬套材料的耐腐蚀性,研究了铜合金中添加元素的效果。研究发现,在铜中加入镍可降低铜合金的硫腐蚀。此外,还得知可以通过传统的烧结方法来生产铜镍合金。尝试在铜基体中加入硬颗粒来提高耐磨性。研究的首要目标是确定硬颗粒对耐磨性和切削加工工艺性的影响。研究发现,在铜基体中加入一种硬颗粒时耐磨性有所提高,但切削加工性却变差。为了解决这个问题,试验同时添加两种硬颗粒,细的AIN和Fe3P颗粒。结果是成功地提高了耐磨性,又不使切削加工性变差。在本研究的基础上成功地开发了活塞销衬套新材料,有效地提高了高性能柴油机活塞销衬套的耐磨性和耐腐蚀性。 | Kira T Yokota H Kamiya S 顾如龙 | 2000 | 国外内燃机2000，32，4： | 3 |
| 3 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 4 | Arabidopsis hot2 encodes an endochitinase - like protein that is essential for tolerance to heat, salt and drought stresses 显示文摘 | Kwon Y R Kira S H Jung M S | 2007 | The Plant Journal2007，，49： | 1 |
| 5 | Effects of acute moderate exercise on the phagoeytosis of Kupffer cells in rats 显示文摘 | Yano H Kinoshita S Kira S | 2004 | Acta Physiol Scand2004，182，2： | 1 |
| 6 | Psychological problems in young men with chronic prostatitis-like symptoms显示文摘 | Ku J H Jeon Y S Kira M E | 2002 | Scand J Urol Nephrol2002，36，4： | 1 |
| 7 | Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma 显示文摘 | Ota A Tagawa H Karnan S Tsuzuki S Karpas A Kira S | 2004 | Cancer Res2004，64，9： | 1 |
| 8 | Seismic risk assessment of ar-chitectural heritages in Gyeongju considering local site effects显示文摘 | Park H J Kim D S Kira D M | 2013 | Natural Hazards and Earth System Science2013，13，2： | 1 |
| 9 | Fabrication of conductive, transparent and superhydrophobic thin films consisting of multi- wailed carbon nanotubes 显示文摘 | Park E J Kira K D Yoon H S | 2014 | RSC Advances2014，4，30： | 1 |
| 10 | Longitudinal follow-up study of 11 patients with pulmonary lymphangioleiomyomatosis: diverse clinical courses of LAM allow some patients to be treated without anti-hormone therapy显示文摘 | SEYAMA K KIRA S TAKAHASHI H | 2001 | Respirology2001，6，4： | 1 |
| 11 | Effects of acute moderate exercise on the phagocytosis of Kupffer cells in rats显示文摘 | Yano H Kinoshita S Kira s | | 0，，： | 1 |
| 12 | Market Orientation: A Meta Analytic Review and Assessment of Its Antecedents and Impaction Performance 显示文摘 | KIRA A H JAYACHANDRAN S BEARDEN W O | 2005 | Journal of Marketing2005，69，2： | 1 |
| 13 | Cryptotanshinone inhib-its constitutive signal transducer and activator of transcription3 function through blocking the dimerization in DU145 pros-tate cancer cells显示文摘 | Shin D S Kira H N Shin K D | 2009 | Cancer Res2009，69，： | 1 |
| 14 | Detection of mutagenicity and their ambient water 显示文摘 | KIRA S HAYATSU H OGATA M | 1989 | Bulletin of Environ Contam and Toxic1989，43，： | 1 |
| 15 | Effect of ulinastatin,a human urinary trypsin inhibitor, on the oleic acid induced acute lung injury in rats via the inhibition ofactivated leukocytes显示文摘 | Ito K Mizutani A Kira S Mori M Iwasaka H Noguchi T | 2005 | Injury2005，36，： | 1 |
| 16 | I-dentification and characterization of a novel gene, C13orf25,asa target for I3q31-q32 amplification in malignant lymphoma显示文摘 | Ota A Tagawa H Kaman S Tsuzuki S Karpas A Kira S | 2004 | Cancer i2es2004，64，9： | 1 |
| 17 | Effect of ulinastatin,a human urinary trypsin inhibitor,on the oleic acidinduced acute lung injury in rats via the inhibition of activated leukocytes显示文摘 | Ito K Mizutani A Kira S Mori M Iwasaka H Noguchi T | | Injury.British Journal of Accident Surgery0，，： | 1 |
| 18 | Olprinone decreases elevated concentrations of cytokine-induced neutrophil chemoat- tractant-1 in septic rats显示文摘 | MIYAKAWA H KIRA S OKUDA K | 2008 | J Anesth2008，22，1： | 1 |
| 19 | Effect of Ulinastatin,a human urinary trypsin inhibitor,on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes显示文摘 | Ito K Mizutani A Kira S Mori M Iwasaka H Noguchi T | 2005 | Injury2005，36，： | 1 |
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