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| 1 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 2 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 3 | Wnt-frizzled signaling in neural crest formation显示文摘 | Wu J Saint-Jeannet J P Klein P S | 2003 | Trends Neurosci2003，26，1： | 1 |
| 4 | Microbial ecology: Hu- man gut microbes associated with obesity显示文摘 | Ley R E Turnbaugh P J Klein S | 2006 | Nature2006，7122，444： | 1 |
| 5 | Denitrification in the top soil of managed grasslands in the Netherlands in relation to soil type and fertilizer lever 显示文摘 | DE KLEIN C A M VAN LOGTESTIJIN R S P | 1994 | Plant and Soil1994，163，： | 1 |
| 6 | Organizational socialization:Its content and consequences 显示文摘 | Chao G T O' Leary-Kelly A M Wolf S Klein H J Gardner P D | 1994 | Journal of Applied Psychol- ogy1994，79，5： | 1 |
| 7 | Microbial ecology: human gut microbes associated with obesity 显示文摘 | Ley R E Tumbaugh P J Klein S | 2006 | Nature2006，444，： | 1 |
| 8 | Clinical impact of altered T-cell homeostasis in treated HIV patients enrolled in a large observational cohort显示文摘 | Ndumbi P Gillis J Raboud J M Cooper C Hogg R S Montaner J S Burchell A N Loutfy M R Machouf N Klein M B Tsoukas C M | 2013 | AIDS2013，27，18： | 1 |
| 9 | Cloning and functional analyses of a gene from sugar beet up-regulated upon cyst nematode infection 显示文摘 | Samuelian S Kleine M Ruyter-Spira C P | 2004 | Plant Mol Biol2004，54，1： | 1 |
| 10 | The epidemiology of osteoporosis - Bone Evaluation Study (BEST): an analysis of routine health insur- ance data显示文摘 | Hadji P Klein S Gothe H | 2013 | Dtsch Arztebl Int2013，110，： | 1 |
| 11 | Histone deacetylase is direct target of valproic acid,potent anticonvulsant,mood stabilizer,and teratogen显示文摘 | Phiel C J Zhang F Huang E Y Guenther M G Lazar M A and Klein P S | | 0，，39： | 1 |
| 12 | A high molar extinction coefficient sensitizer for stable dyesensitized solar cells显示文摘 | Wang P Klein C Humphry-Baker R Zakeeruddin S M Gr(a)tzel M | | 0，，03： | 1 |
| 13 | Microbial ecology:human gut microbes associated with obesity 显示文摘 | LEY R E TURNBAUGH P J KLEIN S | 2006 | Nature2006，444，7122： | 1 |
| 14 | A high-throughput AFLP-based method for constructing integrated genetic and physical maps: progress toward a sorghum genome map显示文摘 | Klein R R Cartinhour S W | 2000 | Genome Res2000，10，6： | 1 |
| 15 | Dynamic mechanical studies of hydrolytic degradation in isotropic and oriented Maxon B显示文摘 | Hill S P Montes de Oca H Klein P G | 2006 | Biornaterials2006，27，17： | 1 |
| 16 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 17 | Denitrificafion in grassland soils in the Netherlands in relation to irrigation, N - application rate, soil water content and soil temperature 显示文摘 | De Klein C A M Van Logtestijn R S P | 1996 | Soil Biol Biochem1996，28，2： | 1 |
| 18 | Three-dimensional bridging scale analysis of dynamic fracture显示文摘 | PARK H S KARPOV E G KLEIN P A | 2005 | Journal of Computa- tional Physics2005，207，2： | 1 |
| 19 | Thyrotoxic cardiac disease显示文摘 | Dahl P Danzi S Klein I | 2008 | Curr Heart Fail Rep2008，5，3： | 1 |
| 20 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000，6，12： | 1 |
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