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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Electronic doors to education: Study of high school website accessi bility in Iowa显示文摘 | KLEIN D MYHILL W HANSEN L | 2003 | Behavioral sciences the law2003，21，1： | 1 |
| 3 | An activator protein-1 (AP-1) response element on pro alphal (1) collagen gene is necessary for thyroid hormone-induced inhibition of promoter activity in cardiac fibroblasts显示文摘 | LEE H W KLEIN L E RASER J | 1998 | J Mol Cell Cardiol1998，30，11： | 1 |
| 4 | The incidence and spatial patterns of wheat plants infectd by Fusariym graminearum group land the effect of crown roton yield显示文摘 | Klein T A Burgess L W Ellison F W | 1991 | Australian Journal of Agricultural Research1991，42，3： | 1 |
| 5 | Real-Time ampacity and ground clearance software for integration into smart grid technology显示文摘 | Klein M K Springer P L Black W Z | 2010 | IEEE Transactions on Power Delivery2010，25，3： | 1 |
| 6 | Mortality after emergent percutaneous coro- nary intervention in cardiogenic shock secondary to acute myo- cardial infarction and usefulness of a mortality prediction model 显示文摘 | Klein L W Shaw R E Krone R J Brindis R G Anderson H V Block P C | 2005 | Am J Cardiol2005，96，： | 1 |
| 7 | Head blight of wheat caused by Fusarium graminearum Group 1 in New South Wales in 1983显示文摘 | Burgess L W Klein T A Bryden W L | 1987 | Australasian Plant Pathology1987，16，： | 1 |
| 8 | Instability Growth Patterns of a Shock-Accelerated Thin Fluid Layer 显示文摘 | Jacobs J W Klein D L Jenkins D G | 1993 | Phys Rev Lett1993，70，5： | 1 |
| 9 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 10 | Role of the Bacillussubtilis fatty acid desaturase in membrane adaptation during coldshock显示文摘 | Weber MHW Klein W Muller L | 2001 | Mol Microbiol2001，39，： | 1 |
| 11 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 12 | The role of ToU-like receptors in regulating the immune response against respiratory syncytial virus 显示文摘 | Klein Klouwenberg P Tan L Werkman W van Bleek GM Coenjaerts F | 2009 | Crit Rev Immunol2009，29，6： | 1 |
| 13 | Coronary artery disease in young adults显示文摘 | Klein L W Nathan S | 2003 | J Am Coll Cardiol2003，41，4： | 1 |
| 14 | Mannose-binding lectin:targeting the microbial world for complement attack and opsonophagecytosis 显示文摘 | Jack D L Klein N J Turner M W | 2001 | Immunol Rev2001，180，： | 1 |
| 15 | Recovery and elimination of the biotherapeutic agent,Saccharomyces boulardii,in healthy human volunteers显示文摘 | KLEIN S M ELMER G W MCFARLAND L V | 1993 | Pharmaceutical Research1993，10，11： | 1 |
| 16 | Influence of atrazine and chlorsulfuron on the sapophytic and parastic activity of Fusarium graminearum group显示文摘 | Jeffery S Burgess L W Klein T A | 1990 | Soil Biol Biochem1990，22，： | 1 |
| 17 | Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Moscucci M Fox K A Cannon C P Klein W López-Sendón J Montalescot G | 2003 | Eur Heart J2003，24，： | 1 |
| 18 | Expression of mTOR signaling pathway markers in prostate cancer progression显示文摘 | Kremer C L Klein R R Mendelson J Browne W Samadzedeh L K Vanpatten K | 2006 | Prostate2006，66，： | 1 |
| 19 | Tall rescue performance influenced by irrigation scheduling, cultivar, and mowing height 显示文摘 | Richie W E Green R L Klein G J | 2002 | Crop Science2002，42，6： | 1 |
| 20 | Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease显示文摘 | Treasure C B Klein J L Weintraub W S | 1995 | N Engl J Med1995，332，8： | 1 |
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