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| 1 | Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond显示文摘Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability(MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with MSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer. | Emily M Lin Jun Gong Samuel J Klempner Joseph Chao | 2018 | World Journal of Gastroenterology2018，24，25： | 10 |
| 2 | Targeted therapy for gastric cancer: Molecular pathways and ongoing investigations显示文摘 | Wei Yang Alexander Raufi Samuel J. Klempner | 2014 | BBA - Reviews on Cancer2014，，： | 2 |
| 3 | Two and there Component INPs显示文摘 | | 1989 | Polymer Materials1989，，： | 1 |
| 4 | Radiation necrosis presenting as pseudoprogression (PsP)during Alectinib treatment of previously radiated brain metastases in ALK-positive NSCLC: Implications for disease assessment and management显示文摘 | Ou SH Klempner SJ Azada MC | 2015 | Lung Cancer2015，88，3： | 1 |
| 5 | Glass transitions of topologically interpenetrating polymer networks显示文摘 | Frish K C Klempner D | 1974 | Polym Eng Sci1974，14，9： | 1 |
| 6 | Optimal thresholds in ra-diometric coal separation显示文摘 | Klempner K S Smirnov A I Umanets E D | 1982 | Journal of Mining Science1982，18，6： | 1 |
| 7 | Thermal analysis of polyacry- late-poly(urethane-urea) interpenetrating polymer net- works显示文摘 | Klempner D Frisch H L | 2003 | Journal of Polymer Science Part B: Polymer Letters2003，8，7： | 1 |
| 8 | Recent Advances in Interpenetrating Polymer Networks显示文摘 | Frisch K C Klempner D Frisch H L | 1982 | Polymer Science and Engineering1982，22，17： | 1 |
| 9 | Yersinia pestis pH6 antigen:genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague 显示文摘 | Lindler LE Klempner MS Straley SC | 1990 | Infect Immun1990，58，： | 1 |
| 10 | Sound attenuation of interpenetrating polymer显示文摘 | Wang C L | 1986 | J Appl Polym Sci1986，32，12： | 1 |
| 11 | Identification of a human neutrophil angiotensin I generating protease as cathepsin G 显示文摘 | Tonnesen MG Klempner MS Austen KF | 1982 | J ClinI nvest1982，69，1： | 1 |
| 12 | Immunotherapy for advanced gastric and esophageal cancer: preclifiical rationale and ongoing clinical investigations显示文摘 | Raufl A G Klempner S J | 2015 | J Gastrointest Oncol2015，6，5： | 1 |
| 13 | Recent studies on interpenetrating polymer networks显示文摘 | FRISCH K C KLEMPNER D XIAO H X et ol | 1985 | Polymer Engineering & Science1985，25，12： | 1 |
| 14 | Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis 显示文摘 | Friedberg MH Glantz MJ Klempner MS | 1998 | Cancer1998，82，5： | 1 |
| 15 | Anti-yo anti- body associated with occult fallopian tube carcinoma显示文摘 | Selby K J Warner J Klempner S | 2011 | Int J Gynecol Pathol2011，30，6： | 1 |
| 16 | Clindamycin uptake by human neutrophils 显示文摘 | Klempner MS Styrt B | 1981 | J Infect Dis1981，144，5： | 1 |
| 17 | A review of kinetic studies on the formation of interpenetrating polymer networks 显示文摘 | Suthar B Xiao I4 X Klempner D | 1996 | Polymers for Advanced Technologies1996，7，4： | 1 |
| 18 | Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas,brain metastases,and carcinomatous meningitis显示文摘 | Friedberg MH Glantz MJ Klempner MS | 1998 | 82(5):923-9301998，82，5： | 1 |
| 19 | Recent advances in polymer alloys and IPN technology 显示文摘 | Frisch K C Klempner D Frisch H L | 1983 | Materials and Design1983，4，4： | 1 |
| 20 | Detection of proteins and intact microorganisms using microfabricated flexural plate silicon resonator arrays 显示文摘 | Pepper J Noting R Klempner M | 2003 | Sensors and Actuators B2003，96，3： | 1 |
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