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| 1 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 2 | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?显示文摘 | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter P. Marco Fisichella | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 3 | Withdrawal syndrome after discontinuation of venlafaxine显示文摘 | Agelink M Zitzelsberger A Klieser E | 1997 | Am J Psychiatry1997，154，： | 1 |
| 4 | Risperidone versus clozapine in the treatment of schizophrenic patients with acute symotom显示文摘 | HeinrichK KlieserE Lehmann | 1994 | Prog Neuropsychopharmacol Biol Psychiatry1994，18，： | 1 |
| 5 | Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases显示文摘 | Stefan Swierczynski Eckhard Klieser Romana Illig Beate Alinger-Scharinger Tobias Kiesslich Daniel Neureiter | 2015 | Expert Opinion on Biological Therapy2015，，5： | 1 |
| 6 | Risperidone versus clozapin in treatment of schizophrenia patient with acute symptoms 显示文摘 | Heinrich K Klieser E LehmannE | 1994 | Prog Neuropsychopharmacol Biol Psychiatry1994，18，： | 1 |
| 7 | Sudden death after intravenous application of lorazepam in a patient treated with clozapine显示文摘 | Klimke A Klieser E | | 0，，05： | 1 |
| 8 | Histone deacetylation meets miRNA: epigenetics and post- transcriptional regulation in cancer and chronic diseases显示文摘 | Swierezynski S Klieser E Illig R | 2015 | Expert Opin Biol Ther2015，15，5： | 1 |
| 9 | Endothelial capillaries chemotactically attract tumour cells显示文摘 | Cornelievon Bülow WiebkeHayen AnkeHartmann WolfgangMueller‐Klieser BrunoAllolio VolkerNehls | 2001 | J Pathol2001，，3： | 1 |
| 10 | Lactate: mirror and motor of tumor malignancy 显示文摘 | WALENTA S MUELLER KLIESER W F | 2004 | Semin Radiat Oncol2004，14，3： | 1 |
| 11 | Withdrawal syndrome after discontinuation of venlafaxine 显示文摘 | Agelink MW Zitzclsberger A Klieser E | 1997 | Am J Psychiatry1997，154，10： | 1 |
| 12 | Risperidone versus clozapine in the treatment of schizophrenic patients with acute symptoms: a double blind, randomized trial显示文摘 | Heinrich K Klieser E Lehmann E | 1994 | Prog Neuropsy-chopharmacol Biol Psychiatry1994，18，： | 1 |
| 13 | Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy显示文摘In the last years, our knowledge of the pathogenesis in acute and chronic pancreatitis(AP/CP) as well as in pancreatic cancerogenesis has significantly diversified. Nevertheless, the medicinal therapeutic options are still limited and therapeutic success and patient outcome are poor. Epigenetic deregulation of gene expression is known to contribute to development and progression of AP and CP as well as of pancreatic cancer. Therefore, the selective inhibition of aberrantly active epigenetic regulators can be an effective option for future thera-pies. Histone deacetylases(HDACs) are enzymes that remove an acetyl group from histone tails, thereby causing chromatin compaction and repression of transcri-ption. In this review we present an overview of the currently available literature addressing the role of HDACs in the pancreas and in pancreatic diseases. In pancreatic cancerogenesis, HDACs play a role in the important process of epithelial-mesenchymal-transition, ubiquitin-proteasome pathway and, hypoxia-inducible-factor-1-angiogenesis. Finally, we focus on HDACs as potential therapeutic targets by summarizing currently available histone deacetylase inhibitors. | Eckhard Klieser Stefan Swierczynski Christian Mayr Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 1 |
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