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| 1 | The promises and challenges of patient-derived tumor organoids in drug development and precision oncology显示文摘In the era of precision medicine,cancer researchers and oncologists are eagerly searching for more realistic,cost effective,and timely tumor models to aid drug development and precision oncology.Tumor models that can faithfully recapitulate the histological and molecular characteristics of various human tumors will be extremely valuable in increasing the successful rate of oncology drug development and discovering the most efficacious treatment regimen for cancer patients.Two‐dimensional(2D)cultured cancer cell lines,genetically engineered mouse tumor(GEMT)models,and patient‐derived tumor xenograft(PDTX)models have been widely used to investigate the biology of various types of cancers and test the efficacy of oncology drug candidates.However,due to either the failure to faithfully recapitulate the complexity of patient tumors in the case of 2D cultured cancer cells,or high cost and untimely for drug screening and testing in the case of GEMT and PDTX,new tumor models are urgently needed.The recently developed patient‐derived tumor organoids(PDTO)offer great potentials in uncovering novel biology of cancer development,accelerating the discovery of oncology drugs,and individualizing the treatment of cancers.In this review,we will summarize the recent progress in utilizing PDTO for oncology drug discovery.In addition,we will discuss the potentials and limitations of the current PDTO tumor models. | Lauren M.Granat Ooha Kambhampati Stephanie Klosek Brian Niedzwecki Kian Parsa Dong Zhang | 2019 | Animal Models and Experimental Medicine2019，2，3： | 5 |
| 2 | Visible light driven V-doped TiO2 photocatalyst and its photooxidation of ethanol显示文摘 | Klosek S Raftery D | 2001 | J Phys Chem B2001，105，14： | 1 |
| 3 | A review of air separation technologies and their integration with energy conversion processes显示文摘 | Smith A R Klosek J | 2001 | Fuel Processing Technology2001，70，2： | 1 |
| 4 | STAT3 as a mo- lecular target in RNA interference-based treatment of o- ral squamous cell carcinoma 显示文摘 | Klosek SK Nakashiro K Hara S | 2008 | Oncol Rep2008，20，4： | 1 |
| 5 | Visible light driven V-doped TiO2 photocatalyst and its photoc,xidation of ethanol 显示文摘 | Klosek S Raftery D | 2001 | J Phys Chem B2001，105，14： | 1 |
| 6 | A review of air separation technologies and their integration with energy conversion processes 显示文摘 | Smith A R klosek J | 2001 | Fuel Processing Technology2001，70，2： | 1 |
| 7 | STAT3 as a molecular target in RNA interference - based treatment of oral squamous cell carcinoma显示文摘 | Klosek SK Nakashiro K Hara S | 2008 | Oncol Rep2008，20，4： | 1 |
| 8 | Coproduction of methanol adds IGCC flexibility显示文摘 | Osterstock E R Klosek J Guy K W | 1997 | Mod Power Systems1997，17，10： | 1 |
| 9 | Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1a in human salivary gland cancer cells显示文摘 | Hara S Nakashiro K Klosek SK | 2006 | Oral Oncology2006，42，： | 1 |
| 10 | Multi-scale analysis of sto- chastic delay differential equations 显示文摘 | Klosek M M Kuske R | 2005 | Multi-scale Modeling and Simulation2005，3，： | 1 |
| 11 | Visible light driven V-doped TiO2 photoeatalyst and its photooxidation of ethanol 显示文摘 | Klosek S Raftery D | 2001 | The Journal of Physical Chemistry B2001，105，14： | 1 |
| 12 | Constitutive activation of Stat3 correlates with increased expression of the c-Met/HGF receptor in oral squamous cell carcinoma显示文摘 | Klosek SK Nakashiro K Hara S | 2004 | Oncol Rep2004，12，2： | 1 |
| 13 | Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma 显示文摘 | Ishikawa T Nakashiro K Klosek S K | 2009 | Oncol Rep2009，21，3： | 1 |
| 14 | Hypoxia enhances c- Met/HGF receptor expression and signaling by activating HIF- lalpha in human salivary gland cancer cells 显示文摘 | Hara S Nakashiro K Klosek S K | 2006 | Oral Oncology2006，42，6： | 1 |
| 15 | Residual Stresses Comparison Determined by Short-Wavelength X-Ray Diffraction and Neutron Diffraction for 7075 Aluminum Alloy显示文摘 | Jin Zhang Lin Zheng XueBo Guo Vincent Ji Vincent Klosek | 2014 | Journal of Nondestructive Evaluation2014，，1： | 1 |
| 16 | Chronic steroid administra- tion does not suppress Plasmodium development and maturation 显示文摘 | Rungruang T Klosek S K Parasitol Res | 2007 | Parasitol Res2007，101，4： | 1 |
| 17 | A review of air separation technologies and their integration with energy conversion processes显示文摘 | Smith A R Klosek J | 2001 | Fuel Processing Technology2001，70，2： | 1 |
| 18 | Pricing Upward-Only Adjusting Leases显示文摘 | Ambrose Bent W Hendershott Patric H Klosek Malgorzata M | 2002 | Journal of Real Estate Finance and Economics2002，25，： | 1 |
| 19 | A direct approach to the exit problem显示文摘 | Naeh T Klosek M M Matkowsky B J Schuss Z | 1990 | SIAM J Appl Math1990，50，2： | 1 |
| 20 | Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1α in human salivary gland cancer cells显示文摘 | Hara S Nakashiro K Klosek SK | | 0，，06： | 1 |
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