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| 1 | Role of Hox genes in stem cell differentiation显示文摘Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches. | Anne Seifert David F Werheid Silvana M Knapp Edda Tobiasch | 2015 | World Journal of Stem Cells2015，7，3： | 10 |
| 2 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 3 | Targeted vascular delivery of antisense molecules using intravenous microbubbles 显示文摘 | Porter TR Xie F Knapp D | 2006 | Cardiovasc Revasc Med2006，7，1： | 1 |
| 4 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestris显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 5 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 6 | The fine structure obliquely striated body wall muscles in the earthworm,Lumbricus terrestri 显示文摘 | Knapp M F | 1970 | Journal of Cell Science1970，，7： | 1 |
| 7 | New onset hypertension after extracorporeal shock wave lithotfipsy:age related incidence and prediction by intrarenal resistive index显示文摘 | Janetschek G Frauseher F Knapp R | 1997 | J Urol1997，158，： | 1 |
| 8 | Measurement and analysis of audible noise显示文摘 | Popeck R A Knapp R F | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，4： | 1 |
| 9 | A new pressure-swingdistillation process for separating homogeneous zaeotropic mixtures显示文摘 | KNAPP J P Doherty M F | 1992 | Ind Eng Chem Res1992，31，1： | 1 |
| 10 | Quantum photoyield of diamond (111) a stable nega- tive- affinity emitter 显示文摘 | HIMPSEL F J KNAPP J A VANVECHTEN J A | 1979 | PhysicalReviewB1979，20，2： | 1 |
| 11 | Precision en- gineering for wind energy systems 显示文摘 | GOCH G KNAPP W HAERTIG F | 2012 | CIRP An- nals- Manufacturing Technology2012，61，2： | 1 |
| 12 | Revascularization of femoral head ischemic necrosis with vascularized bone graft:a CT scan experimental study显示文摘 | Gonzalez del Pino J Knapp K Gomez Castresana F | | 0，，： | 1 |
| 13 | Safety assess- ment of dietary diacylglyeerol oil: a two - generation repro- ductive toxicity study in rats 显示文摘 | MORITA O KNAPP J F TAMAKI Y | 2008 | Food Chem Toxicol2008，46，9： | 1 |
| 14 | Thermal integration of homogeneous azeotropic distillation sequences显示文摘 | Knapp J P Doherty M F | 1990 | AIChE Journal1990，36，7： | 1 |
| 15 | Validation study of skull three dimension computerized tomography measurements显示文摘 | Hidebolt C F Vammer M W Knapp R H | | 0，，03： | 1 |
| 16 | Methyl bromide adsorption on activated carbon to control emissions from commodity fumigations显示文摘 | James G Leesch Gerhard F Knapp Bruce E Mackey | 1999 | Journal of Stored Products Research1999，，： | 1 |
| 17 | World Journal of Urology显示文摘 | Uckert S Becker A J Ness B O Stief C G Scheller F Knapp W H Jonas U | 2003 | 4(6):3232003，4，6： | 1 |
| 18 | Protein quality of green mature and sprouted soybeans显示文摘 | Bates R P Knapp F W Araujo P E | 1977 | Food Sci1977，42，： | 1 |
| 19 | Differential roles of CD14 and toll-like receptors 4 anti 2 in murine acinctobacter pneumonia 显示文摘 | Knapp S Catharina W Sandrine F | 2006 | Am J Respir Crit Care Med2006，173，： | 1 |
| 20 | Thermal integration of homogeneous azeotropic distillation sequences显示文摘 | Knapp J P Doherty M F | 1990 | AIChE Journal1990，36，7： | 1 |
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