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| 1 | Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects显示文摘Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver transplantation.NAFLD and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in NAFLD.Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 D.Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD.Therefore,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients.In the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways.We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients.The specific focus was liver histopathology as assessed by the invasive liver biopsy.Additionally,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery. | Tea L Laursen Christoffer A Hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K Knop Henning Grønbæk | 2019 | World Journal of Hepatology2019，11，2： | 11 |
| 2 | Hydroaromatic equilibration during biosynthesis of shikimic acid显示文摘 | Knop D R Draths K M Chandran S S | 2001 | J Am Chem Soc2001，123，10： | 1 |
| 3 | Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus显示文摘 | Aaboe K Knop FK Vilsboll T | 2010 | Diabetes Obes Metab2010，12，4： | 1 |
| 4 | Color-encoded focused image holograms显示文摘 | Knop K | 1976 | Appl Opt1976，15，9： | 1 |
| 5 | In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma显示文摘 | Philipp-Abbrederis K Herrmann K Knop S | 2015 | EMBO Mol Med2015，7，4： | 1 |
| 6 | Analysis of collagen-interacting proteins in patients with incisional hernias 显示文摘 | Rosch R Junge K Knops M | 2003 | Langenbecks Arch Surg2003，387，1112： | 1 |
| 7 | Mechanisms ofplant species impacts on ecosystem nitrogen cycling显示文摘 | Knops J M H Bradley K L Wedin D A | 2002 | Ecology Letters2002，5，3： | 1 |
| 8 | Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells显示文摘 | Mahnke K Qian Y Knop J | 2003 | Blood2003，101，12： | 1 |
| 9 | Mechanisms of plant species impacts on ecosystem nitrogen cycling显示文摘 | Knops J M H Bradley K L Wedlin D A | 2002 | Ecol Let2002，，5： | 1 |
| 10 | Alalysis of collagen-interaction proteins in patients with incisional hernias显示文摘 | Rosch R Junge K Knops M | 2003 | Alangenbecks Arch Surg2003，387，1112： | 1 |
| 11 | Specific leaf area along a ni trogen fertilization gradient显示文摘 | KNOPS J M H REINHART K | 2000 | American Midland Naturalist2000，144，： | 1 |
| 12 | Induction of CD4+/CD25+ regu- latory T cells by targeting of antigens to immature dendritic ceils 显示文摘 | Mahnke K Qian YJ Knop J | 2003 | Blood2003，101，12： | 1 |
| 13 | Increased N availability in grassland soils modifies their microbial communities and decreases the abundance of arbuscular mycorrhizal fungi显示文摘 | Bradley K Drijber R A Knops j | 2006 | Soil Biology and Biogeochemistry2006，38，： | 1 |
| 14 | Human basophils a unique biological instrument to detect the allergenicity of food 显示文摘 | SABATO V VAN HENGEL A J DE KNOP K J | 2011 | Investig Allergol Clin Immunol2011，21，3： | 1 |
| 15 | Mechanisms of plant species impacts on ecosystem nitrogen cycling显示文摘 | Knops J M H Bradley K L Wedlin D A | 2002 | Ecology Letters2002，5，： | 1 |
| 16 | Gene expression in low- and high-dose-irradiated human peripheral blood lymphocytes: possible applications for biodosimetry 显示文摘 | Knops K Boldt S Wolkenhauer 0 | 2012 | Radiation Research Society2012，178，4： | 1 |
| 17 | Role of ultrasound compared to age-related formulas for uncuffed endotracheal intubation in a pediatric population显示文摘 | Schramm C Knop J Jensen K | 2012 | Paediatr Anaesth2012，22，8： | 1 |
| 18 | Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives 显示文摘 | Knop K Hoogenboom R Fischer D | 2010 | Angew Chem lnt EdEngl2010，49，36： | 1 |
| 19 | Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes: a review显示文摘 | HANSEN K B VILSBOLL T KNOP F K | 2010 | Diabetes Metab Syndr Obes2010，3，： | 1 |
| 20 | Rigorous diffraction theory for transmission phase grating with deep rectangular grooves 显示文摘 | Knop K | 1978 | J Opt Soc Am1978，68，9： | 1 |
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