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| 1 | Microencapsulation of fish oil by freeze-drying techniques and influence of process parameters on oxidative stability during storage显示文摘 | Katrin Heinzelmann Knut Franke | 2000 | European Food Research and Technology2000，211，： | 1 |
| 2 | Yeast PAPS reductase: properties and requirements of the purified enzyme显示文摘 | Jens D. Schwenn Frank A. Krone Knut Husmann | 1988 | Archives of Microbiology1988，，4： | 1 |
| 3 | Using freezing and drying techniques of emulsions for the microencapsulation of fish oil to improve oxidation stability显示文摘 | Knut Franke | 1999 | Colloids and Surfaces B:Biointerfaces1999，12，： | 1 |
| 4 | Microencapsulation of fish oil by freeze-drying techniques and influence of process parameters on oxidative stability during storage显示文摘 | Katrin Heinzelmann Knut Franke Joaqu í n Velasco | 2000 | European Food Research and Technology2000，211，4： | 1 |
| 5 | 筛选水平的暴露和风险评估中化学物优先次序及数据要求显示文摘[背景]科学家和监管机构努力确定可能危害人类和环境的化学物质。然而,需要评估的化学物质数量巨大,而数据和资源有限,因此确定优先次序是个挑战。[目的]为了确定化学品暴露与潜在暴露风险的优先次序,并针对研究需要,从定量角度更好地解决筛选评估中的不确定性因素。[方法]采用多媒体质量平衡模型来确定>12000种有机化工原料的优先次序,使用4个远场人类暴露指标,对关键化学品信息的传播差异(不确定性)进行了量化,并以它作为模型输入来计算暴露指标。[结果]模拟的人口浓度和摄入率分别跨越约17和15个数量级。使用人口浓度和单位排放率估计潜在的暴露跨越约13个数量级,摄入分数跨越7个数量级。实际的化学品排放率是导致暴露评估差异(不确定性)的最大因素。人类生物转化半衰期是评估浓度不确定性的第二大来源。一般情况下,在模拟暴露与潜在暴露中,与化学分配系数相比,生物转化和生物降解的半衰期是不确定性的更大来源。[结论]机械暴露模型适用于大量化学品的筛选和确定优先次序。通过包括不确定性分析和暴露评估中化学信息的不确定性,能以系统化的方式帮助识别和解决人类暴露和风险评估中不确定性的重要来源。 | Jon A.Arnot Trevor N.Brown Frank Wania Knut Breivik Michael S.McLachlan | 2013 | 环境与职业医学2013，30，2： | 0 |
| 6 | Efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder and nocturia, current clinical features and outcomes: A systematic review显示文摘Objective To evaluate the efficacy and safety of desmopressin on frequency and urgency in female patients with overactive bladder(OAB)and nocturia.Methods A selective database search was conducted to validate the effectiveness of desmopressin in patients with OAB and nocturia.Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were utilised.The meta-analysis included 378 women(five studies)with OAB.The clinical outcomes and adverse events were analysed.Results The treatment strategy of all the studies included can be divided into three categories:(1)The effect of desmopressin compared with baseline,(2)desmopressin compared with placebo,and(3)desmopressin and anticholinergic combination versus desmopressin monotherapy.There was a significant(50%)reduction in nocturia and urgency episodes after using desmopressin alone.Combined desmopressin and anticholinergic led to a decrease in the frequency of nocturia voids when only using anticholinergic(65%vs.33.2%).The time increased in the middle to the first nightly voids in the combination arm(65.11 min;p=0.045).The mean incidence(standard deviation)of leak-free episodes was higher under desmopressin than under placebo in the first 4 h(62%[35%]vs.48%[40%])and in the first 8 h(55%[37%]vs.40%[41%]).The safety profile was comparable between treatments.Conclusion Available data indicate that desmopressin is efficacious in significantly reducing nighttime urine production,episodes of nocturia,and urgency episodes.The affectivity of the combination therapy was very high with least side effects for the treatment of OAB/nocturnal polyuria. | Bara Barakat Knut Franke Matthias May Ulrich Gauger Thomas-Alexander Vogeli | 2022 | Asian Journal of Urology2022，9，1： | 0 |
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