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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization显示文摘 | Volders H Koetzner CA | 2002 | J Virol2002，76，12： | 1 |
| 3 | Repair and mutagenesis of the genome of a deletion mutant of the coronavirus mouse hepatitis virus by targeted RNA recombination显示文摘 | Koetzner C A Parker M M Ricard C S | 1992 | J Virol1992，66，： | 1 |
| 4 | Analysis of a recombinant mouse hepatitis virus expressing a foreign gene reveals a novel aspect of coronavirus tran- scription显示文摘 | Fischer F Stegen C F Koetzner C A | 1997 | J Virol1997，71，： | 1 |
| 5 | Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization显示文摘 | Volders H Koetzner CA | 2002 | J Virol2002，76，12： | 1 |
| 6 | Coro- navirus maintain viability despite dramatic rearrange- ments of the strictly conserved genome organization 显示文摘 | De Haan C A Voiders H Koetzner C A | 2002 | J Virol2002，76，12： | 1 |
| 7 | Construction of murine coronavirus mutants containing interspecies chimeric nucleocapsid proteins 显示文摘 | Peng D Koetzner C A Mcmahon T Zhu Y Masters P S | 1995 | J Virol1995，67，： | 1 |
| 8 | Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2显示文摘 | Koetzner L Hua XY Lai J | 2004 | J Neurosci2004，24，6： | 1 |
| 9 | Construction of murine coronavirus mutants containing interspecies chimeric nucleocapsid proteins显示文摘 | Peng D Koetzner C A McMahon T | 1995 | J Virol1995，69，： | 1 |
| 10 | The soluble fiber complex PolyglycopleX lowers serum triglycerides and reduces hepatic steatosis in high-sucrosefed rats 显示文摘 | Reimer R A Grover G J Koetzner L Gahler R J Lyon M R Wood S | 2011 | Nutrtion Research2011，31，4： | 1 |
| 11 | Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization显示文摘 | DE HAAN C M VOLDERS H KOETZNER C A | 2002 | J Virol2002，76，12： | 1 |
| 12 | Plant-Derived Polysaccharide Supplements Inhibit Dextran Sulfate Sodium- Induced Colitis in the Rat显示文摘 | Lee Koetzner Gary Grover Jamie Boulet | 2010 | Digestive Diseases and Sciences2010，55，5： | 1 |
| 13 | Construction of murine coronavirus mutants containing interspecies chimeric nucleocapsid proteins 显示文摘 | Peng D Koetzner C A Mcmahon T | 1995 | J Virol1995，69，： | 1 |
| 14 | Plant-derived polysaccharide supplements inhibit dextran sulfate sodium-induced colitis in the rat显示文摘 | Koetzner L Grover G Boulet J | 2010 | Digesrive Disease and Sciences2010，，55： | 1 |
| 15 | Plant-derived polysac- charide supplements inhibit dexlxan sulfate sodium-induced colitis in the rat显示文摘 | KOETZNER L GROVER G BOULET J | 2010 | Dig Dis Sci2010，55，： | 1 |
| 16 | Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography-tandem mass spectrometry:application to pharmacokinetic study显示文摘 | X Xu L Koetzner J Boulet | | 0，，： | 1 |
| 17 | Effects of the Soluble Fiber Complex PolyGlycopleX on Glucose Home- ostasis and Body Weight in Young Zucker Diabetic Rats显示文摘 | Grover GJ Koetzner L Wicks J | 2011 | Front Pharmacol2011，247，： | 1 |
| 18 | Energetic signalling in the control of mitochondrial F1Fo ATP synthase activity in health and disease显示文摘 | GROVER G J MARONE P A KOETZNER L | 2008 | The International Journal of Biochemistry & Cell Biology2008，40，12： | 1 |
| 19 | Analysis of a recombinant mouse hepatitis virus expressing a foreign gene reveals a novel aspect of coronavirus transcription显示文摘 | Fischer F Stegen C F Koetzner C A Masters P S | 1997 | J Virol1997，71，7： | 1 |
| 20 | Analysis of a recombinant mouse hepatitis virus expressing a foreign gene reveals a novel aspect of coronavirus transcription 显示文摘 | Fischer F Stegen C F Koetzner C A | 1997 | Am Soc Microbiol1997，71，7： | 1 |
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