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| 1 | 糖尿病膀胱的尿动力学及病理学改变(附动物实验与临床观察)显示文摘目的:观察糖尿病膀胱(DCP)的尿动力学及病理学改变,探讨发病机制及病理演绎过程。方法:建立DCP wistar大鼠模型(30只),正常wistar大鼠作对照(30只),进行膀胱储尿期压、最大容量、最大膀胱压等测定,进行膀胱湿重、膀胱壁厚度及光镜、电镜的病理学观察。早期DCP患者(32例),晚期DCP(28例)及非DM人群(22例)进行尿流率、压力-流率尿道分布压及括约肌肌电图等测定,作相关统计学处理。结果:①60天后,DCP鼠组与对照组:膀胱储尿期压(0.45±0.08)kPa,(0.60±0.03)kPa(P<0.05);最大膀胱容量(3.49±0.40)ml,(1.82±0.12)ml(P<0.01);最大膀胱压(3.09±0.10)kPa,(4.91±0.30)kPa(P<0.01);膀胱顺应性(1.39±0.11)ml.kPa-1,(0.68±0.07)ml.kPa-1(P<0.01);湿重增加(P<0.01);逼尿肌细胞连接纤维化,成纤维细胞变性及胶原纤维排列紊乱。②相对于对照组,早期DCP患者最大尿流率偏低,为(15.97±5.71)ml.s-1(P<0.05),逼尿肌活动亢进(占59%),逼尿肌/括约肌协同失调(占37.5%);而晚期DCP患者最大尿流率明显下降,为(8.75±4.20)ml.s-1(P<0.01),膀胱容量增加,为(472.5±32.9)ml(P<0.01),剩余尿量增多,为(62.59±19.87)ml(P<0.01),逼尿肌收缩功能减弱。结论:DCP早期就有膀胱的动力学及病理学改变,以逼尿肌活动功能亢进,逼尿肌/括约肌协同失调较常见,晚期以逼尿肌收缩功能减弱为主,建议对DCP患者早期就应给予干预,控制病情的进一步恶化。 | 卫中庆 van Koeveringe G A 田成功 王昱 于洪波 易超然 孙则禹 陈炜 van Kerrebroeck P E | 2005 | 临床泌尿外科杂志2005，20，11： | 11 |
| 2 | 糖尿病膀胱病的临床尿动力学研究显示文摘目的观察糖尿病膀胱病(DCP)患者的尿动力学改变,探讨发病机制及病理演绎过程,减少晚期DCP的发生,为早期诊治提供依据。方法按糖尿病患者病程分为:早期DCP患者组(32例),晚期DCP组(28例)及非糖尿病人群对照组(22例)分别进行尿动力学测定,获得最大尿流率、排尿量、初始感膀胱容量、最大膀胱压力、最大逼尿肌压、最大膀胱容量、残余尿、膀胱颈压、最大尿道压及括约肌肌电图等参数,对以上数据作相关统计学处理。结果相对于正常对照组,早期DCP患者最大尿流率偏低[(15.97±5.71)ml/s,P<0.05],逼尿肌活动亢进(占59%),逼尿肌/括约肌协同失调(占37.5%);而晚期DCP患者最大尿流率明显下降[(8.75±4.20)ml/s,P<0.01],膀胱容量增加[(472.5±32.9)ml,P<0.01],残余尿量增多[(62.59±19.87)ml,P<0.01],逼尿肌收缩功能减弱。结论糖尿病患者在早期就有膀胱尿道的动力学改变,以逼尿肌活动功能亢进、逼尿肌/括约肌协同失调较常见,晚期以逼尿肌收缩功能减弱为主,建议对DCP患者早期就应给予干预,控制病情的进一步恶化。 | 卫中庆 田成功 Gommert van Koeveringe 王昱 孙则禹 于洪波 易超然 陈炜 Philip van Kerrebreck | 2005 | 医师进修杂志(外科版)2005，28，10： | 9 |
| 3 | The guinea pig as a model of gradual urethral obstruction显示文摘 | Mostwin JL Karim OM van Koeveringe G | 1991 | J Urol1991，145，4： | 1 |
| 4 | Buttock placement of the implantable pulse generator:a new implantation technique for sacral neuromodulation-a muhicenter study显示文摘 | Scheepens WA Weil EH Van Koeveringe GA | 2001 | Eur Urol2001，40，： | 1 |
| 5 | Prospectivestudy of the role of transurethral resection of the prostate in patientswith an elevated prostate-specific antigen level,minor lowerurinary tract symptoms,and proven bladder outlet obstruction显示文摘 | Van Renterghem K Van Koeveringe G Achten R | 2008 | Eur Urol2008，54，6： | 1 |
| 6 | M (3) muscarinic receptor expression on suburothelial interstitial cells 显示文摘 | Grol S Essers PB van Koeveringe GA | 2009 | BJU Int2009，104，： | 1 |
| 7 | Longterm efficacy and safety results of the two-stage implantation technique in sacral neuromodulation显示文摘 | Scheepens WA Van Koeveringe GA de Bie RA | 2002 | BJU Int2002，90，9： | 1 |
| 8 | On the nature of bladder sensation:the concept of sensory modulation显示文摘 | De Wachter S G Heeringa R van Koeveringe G A | 2011 | Neurourol Urodyn2011，30，7： | 1 |
| 9 | M 3 Muscarinic Receptor-Like Immunoreactivity in Sham Operated and Obstructed Guinea Pig Bladders显示文摘 | Simone Grol Christopher John Nile Piluca Martinez-Martinez Gommert van Koeveringe Stefan de Wachter Jan de Vente James I. Gillespie | 2011 | The Journal of Urology2011，，5： | 1 |
| 10 | Clinical relevance of transurethral resection of the prostate in 'asymptomatie' patients with an elevated prostate-specific antigen level 显示文摘 | van Renterghem K Van Koeveringe G Achten R | 2007 | Eur Urol2007，52，3： | 1 |
| 11 | Overactive Bladder Syn- drome and the Potential Role of Prostaglandins and Phosphodiesterases: An Introduction显示文摘 | Rahnama'i MS Van Koeveringe GA | 2013 | Nephro-urology Monthly2013，5，4： | 1 |
| 12 | Overactive Bladder Syndrome and the Potential Role of Prostaglandins and Phosphodiesterases: An Introduction 显示文摘 | Rahnama'i MS Van Koeveringe GA | 2013 | Nephro-urology Monthly2013，5，4： | 1 |
| 13 | M (3) muscarinic receptor expression on suburothelial interstitial cells显示文摘 | GROL S ESSERS P B VAN KOEVERINGE G A | 2009 | BJU Int2009，104，3： | 1 |
| 14 | M(3)muscarinic receptor expression on suburothelial interstitial cells显示文摘 | Grol S Essers PB van Koeveringe GA | | 0，，03： | 1 |
| 15 | Detrusor underactivity:a plea for new approaches to a common bladder dysfunction显示文摘 | van Koeveringe GA Vahabi B Andersson KE | 2011 | Neurourol Urodyn2011，30，5： | 1 |
| 16 | Prospective study of the role of transurethral resection of the prostate in patients with an elevated prostate-specific antigen level,minor lower urinary tract symptoms,and proven bladder outlet obstruction显示文摘 | van Renterghem K Van Koeveringe G Achten R | 2008 | Eur Urol2008，54，6： | 1 |
| 17 | Affective symptoms and the overactive bladder-A systematic review显示文摘 | Vrijens D Drossaerts J van Koeveringe G | 2015 | J Psychosom Res2015，78，2： | 1 |
| 18 | Forced diuresis as a tool for the non-invasive evaluation of bladder sensation显示文摘 | Heeringa R Koeveringe GA Kerrebroeck PEV | 2010 | Neurourology and Urodynamics2010，29，： | 1 |
| 19 | Role and current situation of TURP in patients with elevated PSA显示文摘 | van Renterghem KM van Kerrebroeck PE van Koeveringe GA | 2010 | Arch Esp Urol2010，63，6： | 1 |
| 20 | Long-term clinical outcome of diagnostic transure- thral resection of the prostate in patients with elevated prostate-specific antigen level and minor lower urinary tract symptoms显示文摘 | van Renterghem K van Koeveringe G Achten R | 2009 | Urol Int2009，83，： | 1 |
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