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| 1 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
| 2 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | | 0，，05： | 1 |
| 3 | A common mech- anism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
| 4 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
| 5 | How antibiotics kill bacteria:from targets to networks 显示文摘 | Kohanski MA Dwyer DJ Collins JJ | 2010 | Nat Rev Microbiol2010，8，6： | 1 |
| 6 | A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo显示文摘 | Manchem VP Goldfine ID Kohanski RA | 2001 | Diabetes2001，50，4： | 1 |
| 7 | StatS is a physiological substrate of the insulin receptor显示文摘 | ChenJ Sadowski HB Kohanski RA | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
| 8 | The impact of endoscopic sinus surgery and aspirin desensitization on psychological burden in aspirin-exacerbated respiratory disease显示文摘Background:Aspirin-exacerbated respiratory disease(AERD)is an aggressive inflammatory disorder of the upper and lower respiratory tract.Corticosteroids,leukotriene modifiers,endoscopic sinus surgery(ESS),aspirin(ASA)desensitization,and biological immu-nomodulators are currently used to treat the disorder.Objective:The objective of this study was to determine the psychosocial impact of ESS and ASA desensitization on AERD patients.Methods:All AERD patients who underwent complete ESS were divided into two cohorts based on ASA desensitization status.The psychosocial metrics of the SNOT-22 were collected and analyzed at the following time points:pre-operative,1-month,3-month,6-month,and 12-month after ESS.Results:One hundred and eighty-four AERD patients underwent ESS from November 2009 to November 2018.From this group,130 patients underwent ASA desensitization(AD cohort)and 54 patients remained non-desensitized(ND cohort).AD patients showed a significantly greater reduction in total SNOT-22 scores over the study period compared to ND patients(p=0.0446).Analysis of SNOT-22 psychosocial metrics showed a significantly greater improvement in patient productivity in the AD cohort when compared to the ND cohort(p=0.0214).Further,a sub-group analysis accounting for subject attrition showed a significantly greater improvement in both productivity and concentration in AD patients when compared to the ND cohort(productivity:p=0.0068;concentration:p=0.0428).Conclusions:ESS followed by ASA desensitization decreases the overall psychosocial burden in AERD patients with a significant improvement in perceived productivity and concentration.This has significant implications given the psychosocial impact of chronic diseases. | Tran Locke Auddie Sweis Theodore Lin Brian Sweis Patrick Gleeson Michael Kohanski Nithin Adappa James Palmer John Bosso | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 1 |
| 9 | How antibiotics kill bacteria: from targets to networks 显示文摘 | Kohanski MA Dwyer DJ Collins JJ | 2010 | Nat Rev Microbiol2010，8，6： | 1 |
| 10 | A common mechanism of cellular death induced by bactericidal antibiotics 显示文摘 | Kohanski MA Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
| 11 | Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis 显示文摘 | KOHANSKI MA DEPRISTO MA COLLINS JJ | 2010 | Mol Cell2010，37，3： | 1 |
| 12 | STAT5 is a physiological substrate of the insulin receptor 显示文摘 | Chen J Sadowski H B Kohanski R A | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
| 13 | A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo显示文摘 | Manchem VP Goldfine ID Kohanski RA | 2001 | Diabetes2001，50，： | 1 |
| 14 | A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo显示文摘 | Manchem V P Goldfine I D Kohanski R A | 2001 | Diabetes2001，50，4： | 1 |
| 15 | Role of reactive oxygen species in antibiotic action and resistance显示文摘 | Dwyer DJ Kohanski MA Collins JJ | 2009 | Curr Opin Microbi ol2009，12，5： | 1 |
| 16 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
| 17 | How antibiotics kill bacteria:from targets to networks显示文摘 | Kohanski M A Dwyer D J Collins J J | 2010 | Nat Rev Microbiol2010，8，： | 1 |
| 18 | Antibiotic- induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis显示文摘 | Dwyer D J Camacho D M Kohanski M A | 2012 | Mol Cell2012，46，5： | 1 |
| 19 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | KOHANSKI M A DWYER D J HAYETE B | 2007 | Cell2007，130，5： | 1 |
| 20 | A common mechanism of cellular death induced by bactericidal antibiotics显示文摘 | Kohanski M A Dwyer D J Hayete B | 2007 | Cell2007，130，5： | 1 |
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