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| 1 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 2 | The mechanisms of placental viralinfection显示文摘 | Koi H Zhang J Parry S | 2001 | Ann N Y Acad Sci2001，943，： | 1 |
| 3 | Electrodeposition of CuInSe2 thin films onto Mo-glass substrates显示文摘 | Kois J Bereznev S Mellikov E -pik A | 2006 | Thin Solid Films2006，，： | 1 |
| 4 | Expression of SHOOT MER1STEMLESS, WUSCHEL, and ASYMMETRIC LEAVES1 homologs in the shoots of Podostemaceae: Implications for the evolution of novel shoot organogenesis显示文摘 | Katayama N Koi S Kato M | 2010 | The Plant Cell2010，22，7： | 1 |
| 5 | Redox shuttle additives for chemical overcharge protection in lithium ion batteries 显示文摘 | LEE D Y LEE H S KOI H S | 2002 | Korean J Chem Eng2002，19，4： | 1 |
| 6 | Singapore's lntemet shoppers and their impact on traditional shopping patterns 显示文摘 | Sim L L Koi S M | 2002 | Journal of Retailing and Consumer Services2002，9，2： | 1 |
| 7 | Electrodepostion of CuInSe2 thin films onto Mo-glass substrates显示文摘 | Kois J Bereznev S Mellikov E | 2005 | Thin Solid Films2005，，： | 1 |
| 8 | One-step electrochemical deposition of CulnSe2 absorber layers 显示文摘 | KOIS J VOLOBUJEVA O BEREZNEV S | 2008 | Phys Status Solidi2008，5，4： | 1 |
| 9 | Singapore' s intemet shoppers and their im- pact on traditional shopping patterns 显示文摘 | Sim L L Koi S M | 2002 | Journal of Retailing and Consumer Services2002，9，2： | 1 |
| 10 | CdSe nanofiber and nanohorn structures on ITO substrates fabricated by electrochemical deposition 显示文摘 | KOIS J GUREVITS J BEREZNEV S | 2013 | Applied surface science2013，283，： | 1 |
| 11 | Non-eell-autonomous mieroRNA165 acts in a dose-dependent manner to regulate multiple differentiation status in the Arabidopsis root显示文摘 | Miyashima S Koi S Hashimoto T Nakaji:rna K | 2011 | Development2011，138，： | 1 |
| 12 | Redox shuttle additives for chemical overcharge protection in lithium ion batteries显示文摘 | LEE D Y LEE H S KOI H S | 2002 | Korean J Chem Eng2002，19，4： | 1 |
| 13 | Electrodeposition of CuInSe2 thin films onto Mo-glass substrates 显示文摘 | Kois J Bereznev S Mellikov E Opik A | 2006 | Thin Solid Films2006，511，512： | 1 |
| 14 | Electrodeposition of CuInSe2 thin films onto Mo-glass substrates 显示文摘 | KOIS J BEREZNEV S MELLIKOV E | 2006 | Thin Solid Films2006，，511512： | 1 |
| 15 | Both episomal and integrated forms of human papillomavirus type 16 are invovled in invasive cervical cancers显示文摘 | Matsukura T Koi S Sugase M | 1989 | Virology1989，172，1： | 1 |
| 16 | Electrodeposition of CuInSe2 thin films onto Mo-glass substrates显示文摘 | KOIS J BEREZNEV S MELLIKOV E | | 0，，： | 1 |
| 17 | Allelotype of uterine cancer by analysis of RFLP and microsatellie polymorphisms: frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p 显示文摘 | Jones M H Koi S Fujimoto I | 1994 | Genes Chromosome Cancer1994，9，2： | 1 |
| 18 | Non-cell-autonomous microRNA165 acts in a dose-dependent manner to regulate multiple differentiation status in the Arabidopsis root显示文摘 | S Koi S Hashimoto T | 2011 | Development2011，138，11： | 1 |
| 19 | Transcytosis of Human immunodeficiency virus 1 across the placenta is enhancedby t reat ment with t umou r necrosis factor alpha显示文摘 | Parry S Zhang J Koi H | 2006 | J GenViro2006，87，8： | 1 |
| 20 | Transcytosis of Human immunodeficiency virus 1 across the placenta is enhanced by treatment with tumour necrosis factor alpha显示文摘 | Parry S Zhang J Koi H et a1 | 2006 | J Gen Viro2006，87，8： | 1 |
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