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| 1 | Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human显示文摘AIM: To elucidate the sequential transfer of iron amongst ferritin, transferrin and transferrin receptor under various iron status conditions. METHODS: Incorporation of 59Fe into mucosal and luminal proteins was carried out in control WKY rats. The sequential transfer of iron amongst ferritin, transferrin and transferrin receptor was carried out in iron deficient, control and iron overloaded rats. The duodenal proteins were subjected to immunoprecipitation and quantitation by specific ELISA and in situ localization by microautoradiography and immunohistochemistry in tandem duodenal sections. Human duodenal biopsy (n = 36) collected from subjects with differing iron status were also stained for these proteins. RESULTS: Ferritin was identified as the major protein that incorporated iron in a time-dependent manner in the duodenal mucosa. The concentration of mucosal ferritin was significantly higher in the iron excess group compared to control, iron deficient groups (731.5 ± 191.96 vs 308.3 ± 123.36, 731.5 ± 191.96 vs 256.0 ± 1.19, P < 0.005), while that of luminal transferrin which was significantly higher than the mucosal did not differ among the groups (10.9 ± 7.6 vs 0.87 ± 0.79, 11.1 ± 10.3 vs 0.80 ± 1.20, 6.8 ± 4.7 vs 0.61 ± 0.63, P < 0.001). In situ grading of proteins and iron, and their superimposition, suggested the occurrence of a sequential transfer of iron. This was demonstrated to occur through the initial binding of iron to luminal transferrin then to absorptive cell surface transferrin receptors. The staining intensity of these proteins variedaccording to the iron nutrition in humans, with intense staining of transferrin receptor observed in iron deficient subjects. CONCLUSION: It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin. | Vasantha L Kolachala B Sesikeran K Madhavan Nair | 2007 | World Journal of Gastroenterology2007，13，7： | 2 |
| 2 | Adenosine 2 B receptors ( A ( 2 B ) AR) on enteric neurons regulate murine distal colonic motility 显示文摘 | Chandrasekharan BP Kolachala VL Dalmasso Glynnetwwwdagriorglyn- net | 2009 | FASEB J2009，23，8： | 1 |
| 3 | Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver显示文摘 | Gupta NA Kolachala VL Jiang R | 2014 | Am J Physiol Gastrointest Liver Physiol2014，307，11： | 1 |
| 4 | The glucagon -like peptide - 1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipot- ysis显示文摘 | Gupta NA Kolachala VL Jiang R | 2012 | Am J Pathol2012，181，5： | 1 |
| 5 | A2B adenosine receptor gene deletion attenuates murine colitis显示文摘 | Kolachala VL Vijay-Kumar M Dalmasso G | | 0，，： | 1 |
| 6 | The Glucagon-Like Peptide-1 Receptor Agonist Exendin 4 Has a Protective Role in Ischemic Injury of Lean and Steatotic Liver by Inhibiting Cell Death and Stimulating Lipolysis显示文摘 | Nitika A. Gupta Vasantha L. Kolachala Rong Jiang Carlos Abramowsky Rene Romero Nimita Fifadara Frank Anania Stuart Knechtle Allan Kirk | 2012 | The American Journal of Pathology2012，，5： | 1 |
| 7 | Blockade of adenosine A2B receptors ameliorates murine colitis显示文摘 | Kolachala V Ruble B Vijay-Kumar M | | 0，，01： | 1 |
| 8 | A2B adenosine receptor gene deletion attenuates murine colitis显示文摘 | Kolachala VL Vijay-Kumar M Dalmasso G | | 0，，03： | 1 |
| 9 | A(2B)AR expression in non-immune cells plays an important role in the development of murine colitis显示文摘 | Ingersoll SA Laroui H Kolachala VL | | 0，，10： | 1 |
| 10 | Purinergic receptors in gastrointestinal inflammation 显示文摘 | Kolachala V L Bajaj R Chalasani M | 2008 | Am J Physiol Gastrointest Liver Physiol2008，294，2： | 1 |
| 11 | Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP显示文摘 | Florencia E. Castaneda Baljit Walia Matam Vijay–Kumar Neal R. Patel Susanne Roser Vasantha L. Kolachala Mauricio Rojas Lixin Wang Gabriela Oprea Pallavi Garg Andrew T. Gewirtz Jesse Roman Didier Merlin Shanthi V. Sitaraman | 2005 | Gastroenterology2005，，6： | 1 |
| 12 | Slow-release nano- particle-encapsulated delivery system for laryngeal injection 显示文摘 | Kolachala VL Henriquez OA Shams S | 2010 | Laryngoscope2010，120，5： | 1 |
| 13 | Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis显示文摘 | Yan YT Kolachala V Dalmasso G | 2009 | Plos One2009，4，6： | 1 |
| 14 | Temporal and spatial analysis of clinical and molecular parameters in dextran Sodium sulfate induced colitis显示文摘 | YAN Yutao KOLACHALA V DALMASSO G | 2009 | PLOS One2009，4，6： | 1 |
| 15 | The glucagon-like peptide- 1 receptor agonist Exendin 4 has a protective role in isehemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipoly- sis 显示文摘 | Gupta NA Kolachala VL Jiang R | 2012 | Am JPathol2012，181，5： | 1 |
| 16 | Slow-release nanoparticle-encapsulated delivery system for laryngeal injection显示文摘 | KOLACHALA V L HENRIQUEZ O A SHAMS S | 2010 | Laryngoscope2010，120，： | 1 |
| 17 | TNF-α upregulates adenosine 2b (A2b) receptor expression and signaling in intestinal epithelial cells: a basis for A2bR overexpression in colitis显示文摘 | V. Kolachala V. Asamoah L. Wang T. S. Obertone T. R. Ziegler D. Merlin S. V. Sitaraman | 2005 | Cellular and Molecular Life Sciences2005，，： | 1 |
| 18 | A se-nescence accelerated mouse model to study aging in the larynx显示文摘 | Kolachala VL Torres-Gonzalez E Mwangi S | 2010 | Otolaryngology Head and Neck Surgery2010，142，： | 1 |
| 19 | The glucagon-like peptide-1 receptor agonist exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis显示文摘 | Gupta NA Kolachala VL Jiang R et at | 2012 | AM J Pathol2012，181，5： | 1 |
| 20 | Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis显示文摘 | YAN Y KOLACHALA V DALMASSO G | 2009 | PLoS One2009，4，6： | 1 |
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