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| 1 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 2 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 3 | Cerebral em- bolism due to a retained pacemaker lead: a case report显示文摘 | BOHM A BANYAI F KOMAROMY K | 1998 | Pac- ing Clin Electrophysiol1998，21，3： | 1 |
| 4 | Relationship between fetal intraeranial pressure and fetal heart rate during labor 显示文摘 | Mocsary P Gaal J Komaromy B | 1970 | Am J Obstet Gynecol1970，106，： | 1 |
| 5 | Overexpression of hormone - sensitive lipase prevents triglyceridc accumulation in adipocytes显示文摘 | SZTALRYD C KOMAROMY M C KRAEMER F B | 1995 | J Clin Invest1995，95，6： | 1 |
| 6 | Diurnal intraocular pressure curves in healthy rhesus macaques (Macaca mulatta) and rhesus macaques with nonnotensive and hypertensive prima- ry open - angleglaucoma 显示文摘 | Komaromy AM Brooks DE Sherwood MB | 1998 | J Glaucoma1998，7，： | 1 |
| 7 | Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes显示文摘 | SZTALRYD C KOMAROMY M C KRAEMER F B | 1995 | J Clin Invest1995，95，： | 1 |
| 8 | The mechanism of antibody-dependent cellular cytotoxicity stimulation by somatostatin in rat peritoneal macrophages 显示文摘 | Foris G Gyimesi E Komaromi I | 1985 | Cell Immunol1985，90，1： | 1 |
| 9 | Corneal thickness and endothelial cell density measured by non-contact specular microscopy and pachymetry in Rhesus macaques(Macaca mulat- ta) with laser-induced ocular hypertension 显示文摘 | Ollivier FJ Brooks DE Komaromy AM | 2003 | Exp Eye Res2003，76，6： | 1 |
| 10 | Corneal thickness and endothelial cell density measured by non-contact specular microscopy and pachymetry in Rhesus meaquea (Macaca mulatta) with laser-induced ocular hypertension显示文摘 | Ollivier FJ Brooks DE Komaromy AM Kallberg ME Andrew SE Sapp HL | 2003 | Exp Eye Res2003，76，6： | 1 |
| 11 | Us Army Employment of Unattended Ground Sen- sors 显示文摘 | Kenneth Elgort Scott Komaromy John Madden Andmv Taylor | 2005 | Proceeding of 2005 System and Information Engi- neering Design Symposium2005，10，： | 1 |
| 12 | Cleavage of factorX IQ byhuman neutrophil elastase results in a novel active truncated form of fac-tor X ID A subunit 显示文摘 | Bagoly Z Fazakas F Komaromi I | 2008 | Thromb Haemost2008，99，4： | 1 |
| 13 | Passive attenuation of eortical pattern evoked potentials with increasing body weight in young male rhesus macaques显示文摘 | Brooks DE Kallberg ME | 2003 | Doe Ophthalmol2003，106，3： | 1 |
| 14 | Equine Multiple Congenital Ocular Anomalies (MCOA) syndrome in PMEL17 (Sil- ver) mutant ponies: five cases显示文摘 | Komaromy AM Rowlan JS La Cmix NC | 2011 | Vet Ophthalmol2011，14，5： | 1 |
| 15 | Steel Jacket Structures for the New Ekofisk Complex in the North Sea显示文摘 | Broughton P Aldridge T Komaromy S | 1998 | Proceedings of the Institution of Civil Engineers: Civil Engineering1998，126，： | 1 |
| 16 | Factor XDebrecen: Gly204Arg mutation in factor X causes the synthesis of a non-secretable protein and severe factor X deficiency显示文摘 | Bereczky Z Bardos H Komaromi I | 2008 | Haematologica2008，93，2： | 1 |
| 17 | Functional and structural analysis ofthe visual system in the rhesus monkey model of optic nervehead ischemia 显示文摘 | Brooks DE Kallbei^ ME Cannon RL Komaromy AM OllivierFJ Malakhova OE | 2004 | Invest Ophthalmol Vis Sci2004，45，6： | 1 |
| 18 | Analysis of membrane and surface protein sequences with the hydrophobic moment plot 显示文摘 | EISENBERG D SCHWARZ E KOMAROMY M WALL R | 1984 | Journal of Molecular Biology1984，179，1： | 1 |
| 19 | The risk of lymphoma and immunomodulators in patients with inflammatory bowel diseases: Results from a population-based cohort in Eastern Europe显示文摘 | Peter L. Lakatos Barbara D. Lovasz Gyula David Tunde Pandur Zsuzsanna Erdelyi Gabor Mester Mihaly Balogh Istvan Szipocs Csaba Molnar Erzsebet Komaromi Petra A. Golovics Zsuzsanna Vegh Michael Mandel Agnes Horvath Miklos Szathmari Lajos S. Kiss Laszlo Laka | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 20 | Reversal of blindness in animal models of Leber congenital amaurosis using optimized AAV2-mediated gene trans-fer显示文摘 | Bennicelli J Wright JF Komaromy A Jacobs JB Hauck B Zelenaia O | 2008 | Mol Ther2008，16，3： | 1 |
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