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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 3 | Stable expression of primary human immunodeficiency virus type 1 structural gene products by use of a noncytopathic Sindbis virus vector显示文摘 | Kong W Tian C J Liu B D | 2002 | J Virol2002，76，11： | 2 |
| 4 | Quantitative X-ray diffraction analysis and its application to various coals显示文摘 | L Lu V Sahajwalla C Kong D Harris | 2001 | Carbon2001，，12： | 2 |
| 5 | Ultraviolet-Emitting ZnO Nanowires Synthesized by a Physical Vapor Deposition Approach显示文摘 | Kong Y C Yu D P Zhang B | 2001 | Appl Phys Lett2001，78，： | 1 |
| 6 | Synthesis of ZSM-5 with intracrystal or intercrystal mesopores by polyvinyl butyral templating method显示文摘 | Zhu H B Liu Z C Kong D J | | 0，，02： | 1 |
| 7 | Genomic organization of the complex alpha-gliadin gene locus in wheat显示文摘 | GU YQ CROSSMAN C KONG X ANDERSON O D | 2004 | Theor Appl Genet2004，109，： | 1 |
| 8 | Ultraviolet-emitting ZnO Nanowires Synthesized by a Physical Vapor Deposition Approach显示文摘 | Kong Y C Yu D P Zhang B | 2001 | Appl Phys Lett( S0003-6951 )2001，78，： | 1 |
| 9 | Challenges in using waterjet machining of NiTi shape memory alloys: An analysis of controlled-depth milling 显示文摘 | KONG M C AXINTE D VOICE W | 2011 | Joumal of Materials Processing Technology2011，211，： | 1 |
| 10 | Numerical Study of Premixed HCCI Engine Combustion and Its Sensitivity to Computational Mesh and Model Uncertainties 显示文摘 | Kong S C Reitz R D | 2003 | Combustion Theory and Modelling2003，7，4： | 1 |
| 11 | Cureumin inhibits hepatic pro- tein-tyrosine phos- phatase 1B and prevents hypertrigly- ceridemia and hepatic steatosis in fructose-fed rats 显示文摘 | Li J M Li Y C Kong L D | 2010 | Hepatology2010，51，5： | 1 |
| 12 | Iodo-bridged complexes of platinum(Ⅱ) and synthesis of cis mixed-amine platinum(Ⅱ) compounds显示文摘 | F D Rochon P C Kong | | 0，，： | 1 |
| 13 | On geometrical accuracy and integrity of surfaces in multi-mode abrasive wa- ter jet machining of NiTi shape memory alloys 显示文摘 | Kong M C Srinivasu D Axinte D | 2013 | CIRP Annals-Manufacturing Technology2013，62，1： | 1 |
| 14 | Microsatellite markers linked to 2 powdery mildew resistance genes introgressed from Triticum carthlicum accession PS5 into common wheat显示文摘 | ZHU Z D ZHOU R H KONG X Y DONG Y C JIA J Z | 2005 | Genorne2005，48，： | 1 |
| 15 | Controlled functionalization of multiwalled carbon nanotubes by in situ atom transfer radical polymerization显示文摘 | KONG H GAO C YAN D | 2004 | Journal of the American Chemical Society2004，126，2： | 1 |
| 16 | Parametric interpolator versus linear interpolator for precision CNC machining显示文摘 | Yang D C H Kong T | 1994 | Computer-Aided Design1994，26，3： | 1 |
| 17 | Controlled functionalization of multiwalled carbon nanotubes by in situ atom transfer radical polymerization显示文摘 | Kong H Gao C Yan D Y | | 0，，2： | 1 |
| 18 | Free flexural vibration analysis of stiffened plates with general elastic boundary supports显示文摘 | OU D Y MAK C M KONG P R | 2012 | World Journal of Modelling and Simulation2012，8，2： | 1 |
| 19 | Modeling and Experiments of HCCI Engine Combustion Using Detailed Chemical Kinetics with Multidimensional CFD显示文摘 | Kong S C Marriott D Reitz D R | 2001 | SAE Paper2001，01，： | 1 |
| 20 | Quantitative X-ray diffraction analysis and its application to various coals显示文摘 | LU L SAHAJWALLA V KONG C HARRIS D | 2001 | Carbon2001，39，12： | 1 |
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