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| 1 | Synthesis and pharmacological properties of naturally occurring prenylated and pyranochalcones as potent anti-inflammatory agents显示文摘An efficient approach has been developed for the synthesis of naturally occurring prenylated chalcones viz. kanzonol C(1), stipulin(2), crotaorixin(3), medicagenin(4), licoagrochalcone A(5) and abyssinone D(6) along with the pyranochalcones paratocarpin C(7), anthyllisone(8) and 3-O-methylabyssinone A(9).The key step of the synthesis is a Claisen–Schmidt condensation. Subsequently, their anti-inflammatory effects were investigated in lipopolysaccharides(LPSs)-induced RAW-264.7 macrophages. Of the synthesized chalcones, compounds 5(IC_(50)= 10.41 μmol/L), 6(IC_(50)= 9.65 μmol/L) and 8(IC_(50)= 15.34 μmol/L) show remarkable activity with no cytotoxicity. Compound 9(IC_(50)= 4.5 μmol/L)exhibits maximum(83.6%) nitric oxide(NO) inhibition, but shows slight cytotoxicity. The results reveal that the chalcones bearing the prenyl group at 3- and/or 5-position on ring A(acetophenone moiety), i.e.,1–4 and 7 show weak, or no inhibition activity, whereas chalcones having the prenyl group only on ring B(aldehyde part), i.e., 5, 6 and 8 show significant activity on the production of inflammatory mediated NO with no cytotoxicity. | Kongara Damodar Jin-Kyung Kim Jong-Gab Jun | 2016 | Chinese Chemical Letters2016，27，5： | 4 |
| 2 | Application of heterogeneous solid acid catalysts for Friedlander synthesis of quinolines显示文摘 | Biswanath Das Kongara Damodar Nikhil Chowdhury Rathod Aravind Kumar | 2007 | Journal of Molecular Catalysis A Chemical2007，，1： | 3 |
| 3 | Extragastrointestinal stromal tumor arising in the pancreas:a case report with a review of the literature显示文摘 | Padhi S Kongara R Uppin SG | 2010 | JOP2010，11，3： | 1 |
| 4 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，11： | 1 |
| 5 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S | 2007 | Genes Dev2007，21，11： | 1 |
| 6 | The interplay between autophagy and ros in tumorigenesis显示文摘 | Kongara S Karantza V | 2012 | Front Oncol2012，2，1： | 1 |
| 7 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | GenesDev2007，21，11： | 1 |
| 8 | Glomemlar filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in sonwith morphine in dogs显示文摘 | Kongara K Chambers P Johnson CB | 2009 | Vet Anaesth Analg2009，36，1： | 1 |
| 9 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | | 0，，11： | 1 |
| 10 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，： | 1 |
| 11 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，： | 1 |
| 12 | Autophagy suppresses tumor progression by limiting chromosomal instability显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，11： | 1 |
| 13 | Glomerular filtration rate after tramadol,parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs显示文摘 | Kongara K Chambers P Johnson C B | | 0，，： | 1 |
| 14 | Extragastrointestinal stromal tumor arising in the pancreas:a case report with a review of the literature显示文摘 | Padhi S Kongara R Uppin SG | 2010 | JOP2010，11，： | 1 |
| 15 | Autophagy suppresses tumor progression by limiting chromosomal instability 显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，11： | 1 |
| 16 | Glomerular filtration rate after tramadol, parecoxib and pindolol following anesthesia and analgesia in comparison with morphine in dogs 显示文摘 | Kongara K Chambers P Johnson C B | 2009 | Vet Anaesth Analg2009，36，1： | 1 |
| 17 | Does deep sedation impact the results of 48 hours catheterless pH testing?显示文摘AIM: To study a cohort of patients undergoing 48 h Bravo pH testing receiving deep sedation with propofol. METHODS: We retrospectively reviewed the charts of 197 patients (81 male, 116 female) who underwent Bravo esophageal pH monitoring from July 2003 to January 2008. All patients underwent Bravo pH probe placement via esophagogastroduodenoscopy (EGD) and received propofol for sedation. Patients on a proton pump inhibitor (89 patients) were excluded. Acid reflux variables measured included the total, upright, and supine fractions of time at pH < 4 and DeMeester score, and were compared between day 1 and day 2. RESULTS: Of the 108 patients that were included in the study, the most common indication for Bravo pH monitoring was heartburn, with chest pain being the second most common. A signed rank test revealed no statistically significant difference between day 1 and day 2 reflux episodes. CONCLUSION: Patients who received propofol for sedation for EGD with Bravo pH capsule placement did not experience any significant difference in reflux episodes from day 1 to day 2. | Vineet Korrapati Jay P Babich Anil Balani James H Grendell, Kavita R Kongara Anil Balani James H Grendell Kavita R Kongara | 2011 | World Journal of Gastroenterology2011，17，10： | 1 |
| 18 | Autophagy suppresses tumor progression by limiting chromosomal instability 显示文摘 | Mathew R Kongara S Beaudoin B | 2007 | Genes Dev2007，21，11： | 1 |
| 19 | Effects of tramad- ol, morphine or their combination in dogs undergoing ovariohystereetomy on peri-operative electroencepha|o- graphic responses and post-operative pain显示文摘 | Kongara K Chambers JP Johnson CB | 2012 | N Z Vet J2012，60，2： | 1 |
| 20 | The interplay between autophagy and ROS in tumorigenesis显示文摘 | Kongara S Karantza V | 2012 | Front Oncol2012，2，： | 1 |
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