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8篇 您的检索式：作者名="Kook KA"

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		题名	作者	年代	出处	被引量
	1	Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.	Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu	2019	Bone Research2019，7，2：	5
	2	Repeated swim-stress reduces GABAA receptor alpha subunit mRNAs in the mouse hippocampus 显示文摘	Montpied P Weizman A Weizman R Kook KA Morrow AL Paul SM	1993	Brain Res Mol Brain Res1993，18，3：	1
	3	Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium(MPP(+))model of Parkinson's disease显示文摘	Kook YH Ka M Um M	2011	Biochem Biophys Res Commun2011，411，2：	1
	4	Neuroprotective eytokines repress PUMA induc- tion in the 1-methyl-4-phenylpyridinium MPP( + ) model of Parkinsong disease 显示文摘	Kook YH Ka M Urn M	2011	Biochern Biophys Res Cnmmun2011，411，2：	1
	5	Thalidomide does not alter estrogen-progesterone hormone single dose pharmacokinetics显示文摘	cheffler MR Colbum W Kook KA	1999	Clin Pharmacol Ther1999，65，5：	1
	6	Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP+) model of Parkinson's disease显示文摘	Kook YH Ka M Um M	2011	Biochem Biophys Res Commun2011，411，2：	1
	7	Nenroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium( MPP( + ) ) model of Parkinson ' s disease 显示文摘	Kook YH Ka M Um M	2011	Biochem Biophys Res Commun2011，411，2：	1
	8	Analysis of amiodarone and desethylamiodarone in serum and tears by high-performance liquid chromatography显示文摘	Muir KT Kook KA	1986	J Chromat1986，374，2：	1

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