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| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Pancreatic duct guidewire placement for biliary cannulation in a single-session therapeutic ERCP显示文摘AIM: To investigate the technical success and clinical complication rate of a cannulated pancreatic duct with guidewire for biliary access. METHODS: During a five-year study period, a total of 2843 patients were included in this retrospective analysis. Initial biliary cannulation method consisted of single-guidewire technique (SGT) for up to 5 attempts, followed by double-guidewire technique (DGT) when repeated unintentional pancreatic duct cannulation had taken place. Pre-cut papillotomy technique was reserved for when DGT had failed or no pancreatic duct cannulation had been previously achieved. Main outcome measurements were defined as biliary cannu-lation success and post-endoscopic retrograde cholangiopancreatography (ERCP) complication rate. RESULTS: SGT (92.3% success rate) was characterized by statistically significant enhanced patient outcome compared to either the DGT (43.8%, P < 0.001), pre-cut failed DGT (73%, P < 0.001) or pre-cut as first step method (80.6%, P = 0.002). Pre-cut as first step method offered a statistically significantly more favorable outcome compared to the DGT (P < 0.001). The incidence of post-ERCP pancreatitis did not differ in a statistically significant manner between either method (SGT: 5.3%, DGT: 6.1%, Pre-cut failed DGT: 7.9%, Pre-cut as first step: 7.5%) or with patients' gender. CONCLUSION: Although DGT success rate proved not to be superior to SGT or pre-cut papillotomy, it is considered highly satisfactory in terms of safety in order to avoid the risk of a pre-cut when biliary therapy is necessary in difficult-to-cannulate cases. | Dimitrios Xinopoulos Stefanos P Bassioukas Dimitrios Kypreos Dimitrios Korkolis Andreas Scorilas Konstantinos Mavridis Dimitrios Dimitroulopoulos Emmanouil Paraskevas | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 3 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 4 | Revascularization alone (without mitral valve repair) suffices in patients with advanced ischemic eardiomyopathy and mildto-moderate mitral regurgitation显示文摘 | TOLLS G A J R KORKOLIS D P KOPF G S | 2002 | Ann Thorac Surg2002，74，5： | 1 |
| 5 | Revascularization alone ( without mitral valve repair) suffices in patients with advanced ischemic cardiomyopathy and mild - to - moderate mitral regurgitation 显示文摘 | Tolis GA Jr Korkolis DP Kopf GS | 2002 | Ann Thorac Surg2002，74，5： | 1 |
| 6 | Revascularation alone ( without mitral valve repair) suffices in patients with advaced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation 显示文摘 | Tolis GA Jr Korkolis DP Kopf GS | 2002 | Ann Thorac Surg2002，74，5： | 1 |
| 7 | Primary malignant melanoma of the duodenum: aggressive management and long-term survival of an unusual oncologic entity 显示文摘 | Korkolis DP Apostolaki K Gontikakis E | 2008 | South Med J2008，101，8： | 1 |
| 8 | Revascularization alone(without mitral valve repair)suffices in patients with advanced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation显示文摘 | TOLIS G A Jr KORKOLIS D P KOPF G S et a1 | 2002 | Ann Thorac Surg2002，74，5： | 1 |
| 9 | Mechanics and full-field deformation study of the ring hoop tension test 显示文摘 | Dick C P Korkolis Y P | 2014 | Int''lJ Solids and Structures2014，51，18： | 1 |
| 10 | Tumor histology and stage but not p53, Her2-neu or cathepsin D expression are independent prognosis factors in breast cancer patients显示文摘 | Korkolis DP Tsoli E Fouskakis D | 2004 | Antieancer Res2004，24，3： | 1 |
| 11 | Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections显示文摘 | KOULLIAS G J RAVICHANDRAN P KORKOLIS D P | 2004 | Ann Thorac Surg2004，78，6： | 1 |
| 12 | Increased tissue microarray MMP expression favors proteolysis in thoracic aortic aneurysms and disse-ctions 显示文摘 | KOULIAS G J RAVICHANDRAN P KORKOLIS D P | 2004 | Ann Thorac Surg2004，78，6： | 1 |
| 13 | Pre-operative chemoradiotherapy with oral capecitabine in locally advance,resectable rectal cancer显示文摘 | Korkolis DP Boskos CS Plataniotis GD | 2007 | Anticancer Res2007，27，1： | 1 |
| 14 | Increased Tissue Microarray Matrix Metalloproteinase Expression Favors Proteolysis in Thoracic Aortic Aneurysms and Dissections显示文摘 | George J. Koullias Pars Ravichandran Dimitris P. Korkolis David L. Rimm John A. Elefteriades | 2004 | The Annals of Thoracic Surgery2004，，6： | 1 |
| 15 | HER-2/neu overexpression in breast cancer:an immunohistochemical study including correlations with clinicopathologic parameters,p53 oncoprotein and cathepsin-D显示文摘 | Korkolis D Ardavanis A Yotis J | 2001 | Anticancer Res2001，21，： | 1 |
| 16 | Open or Laparoscopic Surgery for Colorectal Cancer: A Retrospective Comparative Study显示文摘 | Maria Kapritsou Dimitrios P. Korkolis Evangelos A. Konstantinou | 2013 | Gastroenterology Nursing2013，，1： | 1 |
| 17 | Tissue microarray detection of matrix metalloproteinases in diseased tricuspid and bicuspid aortic valves with or without pathology of the ascending aorta显示文摘 | Koullias GJ Korkolis DP Ravichandran P | 2004 | Eur J Cardio-thoracic Surg2004，26，： | 1 |
| 18 | Current assessment and management of spontaneous pneumomediastinum: experience in 24 adult patients显示文摘 | Koullisd GJ Korkolis DP Wang XJ | 2004 | Eur J Cardiothorac Surg2004，25，5： | 1 |
| 19 | Current assessment and management of spontaneous pneumomediastinum: experience in 24 adult patients显示文摘 | George J. Koullias Dimitris P. Korkolis Xu Jie Wang Graeme L. Hammond | 2004 | European Journal of Cardio-Thoracic Surgery2004，，5： | 1 |
| 20 | HER-2/neu overexpression in breast cancer: an immunohistochemical study including correlations with clinicopathologic parameters, p53 oncoprotein and cathepsin-D 显示文摘 | Korkolis D Ardavanis A Yotis J | 2001 | Anticancer Res2001，21，3： | 1 |
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