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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Utilization of narrow-band ultraviolet light B therapy and etanerccpt for the treatment of psoriasis (UNITE) : efficacy, safety, and patient-reported outcomes 显示文摘 | Kircik L Bagel J Korman N | 2008 | Drugs Dermato12008，7，3： | 1 |
| 3 | Principles and use of anti-CTLA4 antibody in human cancer immunotherapy显示文摘 | Quezada SA Korman AJ | 2006 | Curr Opin Immunol2006，18，2： | 1 |
| 4 | Complications of stone baskets: 14-year review of the manufacturer and user facility device experience database显示文摘 | Chotikawanich E Korman E Monga M | 2011 | J Urol2011，85，： | 1 |
| 5 | Giardia Lamblia,Hapoid genome size determined by pulsed field gel electrophoresis is less than 12Mb显示文摘 | Fan J B S H Korman C R Canter | 1991 | Nucleic Acids Res1991，19，： | 1 |
| 6 | Topical capsaicin treatment of chronic postherpetic neuralgia 显示文摘 | Bernstain JE Korman N J Bickers D R | 1989 | Journal of the American Academy of dermatology1989，21，： | 1 |
| 7 | Solution Curves for Two Classes of Boundary Value Problems显示文摘 | Ouyang T | 1996 | Nonlinear Anal1996，27，9： | 1 |
| 8 | Mesh configurations in laparoscopic extraperitoneal heriorrhaphy:a comparison of techniques显示文摘 | Hiatt JR Feldmar D | 1997 | Surg Endosc1997，11，11： | 1 |
| 9 | Identification of Aftereffect Model Parameters: Comparison of Experimental and Simulations 显示文摘 | KORMAN C E RUGKWAMSOOK P | 1997 | IEEE Trans Magn1997，33，： | 1 |
| 10 | Risk factors for adverse cutaneous reactions associated with intravenous vancomycin 显示文摘 | Korman TM Tumidge JD Grayson ML | 2007 | JAntimicrob Chemother2007，39，3： | 1 |
| 11 | Determinants of fasting and postprandial serum bile acid levels in healthy man显示文摘 | N. F. LaRusso N. E. Hoffman M. G. Korman A. F. Hofmann A. E. Cowen | 1978 | The American Journal of Digestive Diseases1978，，5： | 1 |
| 12 | Fibropithelial Polyp of the Renal Pelvis: Nepron Sparing Surgery after False Positive Biopsy for Transitional Cellea Reinoma 显示文摘 | Brady JD Korman HJ Civantos F | 1997 | Urol1997，49，： | 1 |
| 13 | Treatment of erythrodermic psoriasis :From the medical board of the National Psoriasis Foundation 显示文摘 | Rosenbach M Hsu S Korman NJ | 2010 | J Am Acad Dermatol2010，62，4： | 1 |
| 14 | Risk factors for adverse cutaneous reactions associated with intravenous vancomycin显示文摘 | Korman TM Turnidge JD Grayson ML | 1997 | J Antimicrob Chemother1997，39，3： | 1 |
| 15 | Fatal case of toxic shock-like syndrome due to group C Streptococcus associated with superantigen exotoxin显示文摘 | KORMAN T M BOERS A GOODING T M | 2004 | J Clin Microbiol2004，42，： | 1 |
| 16 | Percutaneous endoscopic gastrostomy:a review of indications,complications and outcome显示文摘 | Nicholson FB Korman MG Richardson MA | 2000 | J Gastroenterol Hepatol2000，15，： | 1 |
| 17 | Risk factors for adverse cutaneous reactions associated with intravenous vancomycin 显示文摘 | Korman TM Tarnidge JD Grayson ML | 1997 | J Antimicrob Chemother1997，39，3： | 1 |
| 18 | Performance of urine test in patients monitored for recurrence of bladder cancer:a multicenter study in the United States显示文摘 | Messing EM Teot L Korman H Underhill E Barker E Stork B | | 0，，： | 1 |
| 19 | Treatment of erythrodermic psoriasis: from the medical board of the National Psoriasis Foundation 显示文摘 | Rosenbaeh M Hsu S Korman N J | 2010 | J Am Acad Dermatol2010，62，4： | 1 |
| 20 | Checkpoint Blockade in Cancer Immunotherapy显示文摘 | Alan J. Korman Karl S. Peggs James P. Allison | 2006 | Advances in Immunology2006，，： | 1 |
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