|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions显示文摘 | Haruko K. Shimoda Kotaro Shide Takuro Kameda Takuya Matsunaga Kazuya Shimoda | 2010 | Biochemical and Biophysical Research Communications2010，，2： | 1 |
| 2 | R723 ,a se-lective JAK2 inhibitor,effectively treats JAK2V617F - induced mu-rine myeloproliferative neoplasm 显示文摘 | Kotaro Shide Takuro Kameda Vadim Markovtsov | 2011 | Blood2011，117，25： | 1 |
| 3 | Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis显示文摘Background:Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin,lungs,heart and kidney.However,the contribution of fibrocytes to liver fibrosis is unclear.The aim of this study was to investigate whether fibrocytes contributed to fibrosis progression in the livers of carbon tetrachloride(CCl 4)-treated mice.Methods:C57BL/6J mice were divided into 4 groups:normal control group,CCl 4-treated group,CCl 4+control liposome-treated group,and CCl 4+clodronate liposome-treated group.For the elimination of systemic monocyte and monocyte-derived fibrocyte,one group was treated with clodronate liposome,and another group with control liposome as a control.After 4 weeks of treatment,hepatic mononuclear cells were subjected to immunofluorescent(IF)staining and fluorescence-activated cell sorter(FACS)analysis to detect fibrocytes.Measurement of collagen-positive Sirius red stained area and collagen-I mRNA expression in the liver were performed to evaluate the degree of liver fibrosis quantitatively.Results:In the liver of the CCl 4-treated and CCl 4+control liposome-treated groups,the number of fibrocytes,the area positive for Sirius red staining and collagen-I mRNA expression significantly increased compared with those in the normal control group.In the liver of the CCl 4+clodronate liposome-treated group,few fibrocytes was observed as in the normal control group,but Sirius red staining positive area and collagen-I mRNA expression were increased and equivalent to the CCl 4-treated and CCl 4+control liposome-treated groups.Conclusion:Monocyte-derived fibrocytes play a minimal role in CCl 4-induced liver fibrosis.Cells other than fibrocytes such as hepatic stellate cells play a central role in liver fibrosis. | Yoshinori Ozono Kotaro Shide Fumiyo Toyoshima Yuuka Takaishi Mai Tsuchimochi Ayako Kamiunten Takuro Kameda Kenichi Nakamura Tadashi Miike Kazunori Kusumotoa Hisayoshi Iwakiri Satoru Hasuikea Kenji Nagata Akira Sawaguchi Kazuya Shimoda | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 0 |
| 4 | Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1显示文摘AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype 1.METHODS This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age group.RESULTS The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy. | Yoshinori Ozono Kenji Nagata Satoru Hasuike Hisayoshi Iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike Yoshihiro Tahara Shojiro Yamamoto Kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa Ochiai Junya Kato Naoto Komada Shuichi Hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda | 2017 | World Journal of Hepatology2017，9，36： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员